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Alpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study / Luis Vicente Syro Moreno
Título : Alpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2017 Títulos uniformes : Pathology, Research and Practice Idioma : Inglés (eng) Palabras clave : α-Subunit Glycoprotein hormones Pituitary Pituitary hormones Pituitary tumors Resumen : Pituitary adenomas may be classified as either functioning or non-functioning, depending on whether excess hormone secretion can be clinically identified. Of the six hormones produced in the anterior pituitary, TSH, FSH and LH are known as glycoproteins and contain two subunits (α and β). While α-subunit is identical within all of them, each β-subunit is unique and biologically specific. Independently, the α- and β-subunits are inactive and only induce a hormonal response when they are non-covalently associated. Studies have shown that in certain cases, pituitary adenomas may abnormally secrete only α-subunit, detectable in the serum or through immunohistochemical analysis. In the present study, we examined α-subunit immunoexpression in surgically removed non-functioning pituitary adenomas and analyzed its prognostic value. Results showed that expression of α-subunit in clinically non-functioning pituitary adenomas is not a rare occurrence. While there were no age/gender differences between tumors that expressed α-subunit and those that did not, α-subunit immunonegative adenomas presented with suprasellar extension more frequently and had an Ki67 proliferation greater than 3%. The use of immunohistochemical techniques to determine the presence of α-subunit may provide information on tumor cell proliferation and biologic behavior. To fully understand the role of α-subunit in pituitary adenomas more work is needed. Mención de responsabilidad : Michael Solarski, Fabio Rotondo, Luis V Syro, Michael D Cusimano, Kalman Kovacs Referencia : Pathol Res Pract. 2017 Sep;213(9):1130-1133. DOI (Digital Object Identifier) : 10.1016/j.prp.2017.07.010 PMID : 28780083 En línea : https://linkinghub.elsevier.com/retrieve/pii/S034403381730626X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4032 Alpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study [documento electrónico] / Luis Vicente Syro Moreno, . - 2017.
Obra : Pathology, Research and Practice
Idioma : Inglés (eng)
Palabras clave : α-Subunit Glycoprotein hormones Pituitary Pituitary hormones Pituitary tumors Resumen : Pituitary adenomas may be classified as either functioning or non-functioning, depending on whether excess hormone secretion can be clinically identified. Of the six hormones produced in the anterior pituitary, TSH, FSH and LH are known as glycoproteins and contain two subunits (α and β). While α-subunit is identical within all of them, each β-subunit is unique and biologically specific. Independently, the α- and β-subunits are inactive and only induce a hormonal response when they are non-covalently associated. Studies have shown that in certain cases, pituitary adenomas may abnormally secrete only α-subunit, detectable in the serum or through immunohistochemical analysis. In the present study, we examined α-subunit immunoexpression in surgically removed non-functioning pituitary adenomas and analyzed its prognostic value. Results showed that expression of α-subunit in clinically non-functioning pituitary adenomas is not a rare occurrence. While there were no age/gender differences between tumors that expressed α-subunit and those that did not, α-subunit immunonegative adenomas presented with suprasellar extension more frequently and had an Ki67 proliferation greater than 3%. The use of immunohistochemical techniques to determine the presence of α-subunit may provide information on tumor cell proliferation and biologic behavior. To fully understand the role of α-subunit in pituitary adenomas more work is needed. Mención de responsabilidad : Michael Solarski, Fabio Rotondo, Luis V Syro, Michael D Cusimano, Kalman Kovacs Referencia : Pathol Res Pract. 2017 Sep;213(9):1130-1133. DOI (Digital Object Identifier) : 10.1016/j.prp.2017.07.010 PMID : 28780083 En línea : https://linkinghub.elsevier.com/retrieve/pii/S034403381730626X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4032 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000628 AC-2017-017 Archivo digital Producción Científica Artículos científicos Disponible From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal / Luis Vicente Syro Moreno
Título : From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2017 Títulos uniformes : Endocrine Related Cancer Idioma : Inglés (eng) Palabras clave : Nomenclature pituitary tumors Resumen : The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients. Mención de responsabilidad : S L Asa, O Casar-Borota, P Chanson, E Delgrange, P Earls, S Ezzat, A Grossman, H Ikeda, N Inoshita, N Karavitaki, M Korbonits, E R Laws Jr, M B Lopes, N Maartens, I E McCutcheon, O Mete, H Nishioka, G Raverot, F Roncaroli, W Saeger, L V Syro, A Vasiljevic, C Villa, A Wierinckx, J Trouillas, and the attendees of 14th Meeting of the International Pituitary Pathology Club, Annecy, France, November 2016 Referencia : Endocr Relat Cancer. 2017 Apr;24(4):C5-C8. DOI (Digital Object Identifier) : 10.1530/ERC-17-0004 PMID : 28264912 En línea : https://erc.bioscientifica.com/view/journals/erc/24/4/C5.xml Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4026 From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal [documento electrónico] / Luis Vicente Syro Moreno, . - 2017.
Obra : Endocrine Related Cancer
Idioma : Inglés (eng)
Palabras clave : Nomenclature pituitary tumors Resumen : The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients. Mención de responsabilidad : S L Asa, O Casar-Borota, P Chanson, E Delgrange, P Earls, S Ezzat, A Grossman, H Ikeda, N Inoshita, N Karavitaki, M Korbonits, E R Laws Jr, M B Lopes, N Maartens, I E McCutcheon, O Mete, H Nishioka, G Raverot, F Roncaroli, W Saeger, L V Syro, A Vasiljevic, C Villa, A Wierinckx, J Trouillas, and the attendees of 14th Meeting of the International Pituitary Pathology Club, Annecy, France, November 2016 Referencia : Endocr Relat Cancer. 2017 Apr;24(4):C5-C8. DOI (Digital Object Identifier) : 10.1530/ERC-17-0004 PMID : 28264912 En línea : https://erc.bioscientifica.com/view/journals/erc/24/4/C5.xml Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4026 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000621 AC-2017-010 Archivo digital Producción Científica Artículos científicos Disponible