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Título : Plurihormonality in pituitary adenomas associated with acromegaly Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2006 Títulos uniformes : Endocrine Pathology Idioma : Inglés (eng) Palabras clave : Acromegaly immunohistochemistry pathology pituitary adenoma plurihormonality Resumen : Bihormonal or plurihormonal pituitary tumors produce two or more hormones different in chemical composition, immunoreactivity, and clinical significance. Immunohistochemical and electron microscopic investigations and more recently molecular-genetic studies have provided conclusive evidence of the production of multiple hormones by pituitary adenomas. Most frequently, they produce GH, PRL, TSH, and/or alpha-subunit of the g/y-coprotein hormones. Other uncommon combinations may also be apparent. We report the case of a 40-yr-old acromegalic man with a pituitary macrodenoma. The pituitary tumor was removed by transsphenoidal surgery. Histological, immunohistochemical, electron microscopic, and immunoelectron microscopic examinations revealed that the tumor contains multiple hormones (GH, LH, and alpha subunit) and transcription factors. The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated. Mención de responsabilidad : Fateme Salehi BSc, Sandra Cohen MLT, Luis V. Syro MD, Humberto Uribe MD, Eva Horvath PhD, Kalman Kovacs MD, PhD & Sylvia L. Asa MD, PhD Referencia : Endocr Pathol. Fall 2006;17(3):291-6. DOI (Digital Object Identifier) : 10.1385/EP:17:3:291 PMID : 17308366 En línea : https://link.springer.com/article/10.1385%2FEP%3A17%3A3%3A291 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4417 Plurihormonality in pituitary adenomas associated with acromegaly [documento electrónico] / Luis Vicente Syro Moreno, . - 2006.
Obra : Endocrine Pathology
Idioma : Inglés (eng)
Palabras clave : Acromegaly immunohistochemistry pathology pituitary adenoma plurihormonality Resumen : Bihormonal or plurihormonal pituitary tumors produce two or more hormones different in chemical composition, immunoreactivity, and clinical significance. Immunohistochemical and electron microscopic investigations and more recently molecular-genetic studies have provided conclusive evidence of the production of multiple hormones by pituitary adenomas. Most frequently, they produce GH, PRL, TSH, and/or alpha-subunit of the g/y-coprotein hormones. Other uncommon combinations may also be apparent. We report the case of a 40-yr-old acromegalic man with a pituitary macrodenoma. The pituitary tumor was removed by transsphenoidal surgery. Histological, immunohistochemical, electron microscopic, and immunoelectron microscopic examinations revealed that the tumor contains multiple hormones (GH, LH, and alpha subunit) and transcription factors. The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated. Mención de responsabilidad : Fateme Salehi BSc, Sandra Cohen MLT, Luis V. Syro MD, Humberto Uribe MD, Eva Horvath PhD, Kalman Kovacs MD, PhD & Sylvia L. Asa MD, PhD Referencia : Endocr Pathol. Fall 2006;17(3):291-6. DOI (Digital Object Identifier) : 10.1385/EP:17:3:291 PMID : 17308366 En línea : https://link.springer.com/article/10.1385%2FEP%3A17%3A3%3A291 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4417 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000917 AC-2006-015 Archivo digital Producción Científica Artículos científicos Disponible Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas / Luis Vicente Syro Moreno
Título : Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 1999 Títulos uniformes : Ultrastructural Pathology Idioma : Inglés (eng) Palabras clave : Human Immunoelectron Microscopy Pituitary Adenoma Plurihormonality Ultrastructure Resumen : Momomorphous pituitary adenomas expressing several hormones by immunocytochemistry are common, whereas adenomas displaying multiple immunoreactivities and consisting of more than one morphologic cell types are rare. Three such unusual pituitary adenomas, surgically removed from two patients with acromegaly and one patient with hyperprolactinemia, were investigated by histology, immunocytochemistry, transmission electron microscopy, as well as immunoelectron microscopy using double immunogold labeling. Immunocytochemistry revealed variable degrees of immunoreactivities for growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (beta-TSH), and alpha-subunit of glycoprotein hormones in all three tumors. The three adenomas consisted of phenotypically diverse cell populations as documented by transmission electron microscopy. In addition to monohormonal GH cells, immunoelectron microscopy demonstrated numerous cells colocalizing GH and PRL or GH and beta-TSH, and rarely PRL and beta-TSH in tumors of acromegalics. The adenoma causing hyperprolactinemia consisted chiefly of mammosomatotrophs colocalizing PRL and GH, whereas beta-TSH labeling was scant. The three tumors in the study were selected from a cluster of five plurimorphous plurihormonal adenomas received from the same locale where they accounted for an unprecedented 21% of adenomas producing GH and/or PRL. The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from. Mención de responsabilidad : J F Molina, L R Espinoza Referencia : Ultrastruct Pathol. May-Jun 1999;23(3):141-8. DOI (Digital Object Identifier) : 10.1080/019131299281635 PMID : 10445280 En línea : https://www.tandfonline.com/doi/abs/10.1080/019131299281635 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4385 Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas [documento electrónico] / Luis Vicente Syro Moreno, . - 1999.
Obra : Ultrastructural Pathology
Idioma : Inglés (eng)
Palabras clave : Human Immunoelectron Microscopy Pituitary Adenoma Plurihormonality Ultrastructure Resumen : Momomorphous pituitary adenomas expressing several hormones by immunocytochemistry are common, whereas adenomas displaying multiple immunoreactivities and consisting of more than one morphologic cell types are rare. Three such unusual pituitary adenomas, surgically removed from two patients with acromegaly and one patient with hyperprolactinemia, were investigated by histology, immunocytochemistry, transmission electron microscopy, as well as immunoelectron microscopy using double immunogold labeling. Immunocytochemistry revealed variable degrees of immunoreactivities for growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (beta-TSH), and alpha-subunit of glycoprotein hormones in all three tumors. The three adenomas consisted of phenotypically diverse cell populations as documented by transmission electron microscopy. In addition to monohormonal GH cells, immunoelectron microscopy demonstrated numerous cells colocalizing GH and PRL or GH and beta-TSH, and rarely PRL and beta-TSH in tumors of acromegalics. The adenoma causing hyperprolactinemia consisted chiefly of mammosomatotrophs colocalizing PRL and GH, whereas beta-TSH labeling was scant. The three tumors in the study were selected from a cluster of five plurimorphous plurihormonal adenomas received from the same locale where they accounted for an unprecedented 21% of adenomas producing GH and/or PRL. The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from. Mención de responsabilidad : J F Molina, L R Espinoza Referencia : Ultrastruct Pathol. May-Jun 1999;23(3):141-8. DOI (Digital Object Identifier) : 10.1080/019131299281635 PMID : 10445280 En línea : https://www.tandfonline.com/doi/abs/10.1080/019131299281635 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4385 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000885 AC-1999-003 Archivo digital Producción Científica Artículos científicos Disponible
