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Prescription of antibiotics in intensive care units in Latin America: An observational study / Franco Eduardo Montúfar Andrade
Título : Prescription of antibiotics in intensive care units in Latin America: An observational study Tipo de documento : documento electrónico Autores : Franco Eduardo Montúfar Andrade, Fecha de publicación : 2009 Títulos uniformes : Journal of Chemotherapy Idioma : Inglés (eng) Palabras clave : intensive care unit antibiotics carbapenems resistance Resumen : A one-day point prevalence study to investigate the patterns of antibiotic use was undertaken in 43 Latin American (LA) intensive care units. Of 510 patients admitted, 231 received antibiotic treatment on the day of the study (45%); in 125 cases (54%) due to nosocomial-acquired infections. The most frequent infection reported was nosocomial pneumonia (43%). Only in 122 patients (53%) were cultures performed before starting antibiotic treatment. 33% of the isolated microorganisms were Enterobacteriaceae (40% extended-spectrum β-lactamase-producing), 23% methicillin-resistant Staphylococcus aureus and 17% carbapenems-resistant non-fermentative Gram-negatives. The antibiotics most frequently prescribed were carbapenems (99/231, 43%);alone (60/99, 60%) or in combination with vancomycin (39/99, 40%). “Restricted” antibiotics (carbapenems, vancomycin, piperacillin-tazobactam, broad-spectrum cephalosporins, tigecycline, polymixins and linezolid) were most frequently indicated inseverely ill patients (APACHE II score at admission ≥15, p=0.0007 and, SOFA scoreat the beginning of the antibiotic treatment ≥3, p=0.0000). Only 36% of antibiotictreatments were cultured-directed. Our findings help explain the high rates of multidrug-resistant pathogens in LA settings (i.e. ESBL-producing Gram-negatives) and the severity of the registered patients' illnesses. Mención de responsabilidad : D Curcio, A Alí, A Duarte, A Defilippi Pauta, C Ibáñez-Guzmán, M Chung Sang, E Valencia, F Plano, F Paredes Oña, F Arancibia, F Montufar Andrade, F Morales Alava, G Cañarte Bermudez, G La Fuente Zerain, V Alanis Mirones, J Rojas Suarez, J Guzmán Torrico, J Silva, J Vergara Centeno, J C Medina, K Marín, L A Caero, L Durán Crespo, M Gómez Duque, M Játiva, R Belloni, R Romero, R Aguilera Perrogón, R Camacho Alarcón, R Camargo, S Cevallos, V Intriago Cedeño, Z Urbina Contreras, Latin American Antibiotic Use in Intensive Care Unit Group Referencia : J Chemother. 2009 Nov;21(5):527-34. DOI (Digital Object Identifier) : 10.1179/joc.2009.21.5.527 PMID : 19933044 En línea : https://www.tandfonline.com/doi/abs/10.1179/joc.2009.21.5.527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4457 Prescription of antibiotics in intensive care units in Latin America: An observational study [documento electrónico] / Franco Eduardo Montúfar Andrade, . - 2009.
Obra : Journal of Chemotherapy
Idioma : Inglés (eng)
Palabras clave : intensive care unit antibiotics carbapenems resistance Resumen : A one-day point prevalence study to investigate the patterns of antibiotic use was undertaken in 43 Latin American (LA) intensive care units. Of 510 patients admitted, 231 received antibiotic treatment on the day of the study (45%); in 125 cases (54%) due to nosocomial-acquired infections. The most frequent infection reported was nosocomial pneumonia (43%). Only in 122 patients (53%) were cultures performed before starting antibiotic treatment. 33% of the isolated microorganisms were Enterobacteriaceae (40% extended-spectrum β-lactamase-producing), 23% methicillin-resistant Staphylococcus aureus and 17% carbapenems-resistant non-fermentative Gram-negatives. The antibiotics most frequently prescribed were carbapenems (99/231, 43%);alone (60/99, 60%) or in combination with vancomycin (39/99, 40%). “Restricted” antibiotics (carbapenems, vancomycin, piperacillin-tazobactam, broad-spectrum cephalosporins, tigecycline, polymixins and linezolid) were most frequently indicated inseverely ill patients (APACHE II score at admission ≥15, p=0.0007 and, SOFA scoreat the beginning of the antibiotic treatment ≥3, p=0.0000). Only 36% of antibiotictreatments were cultured-directed. Our findings help explain the high rates of multidrug-resistant pathogens in LA settings (i.e. ESBL-producing Gram-negatives) and the severity of the registered patients' illnesses. Mención de responsabilidad : D Curcio, A Alí, A Duarte, A Defilippi Pauta, C Ibáñez-Guzmán, M Chung Sang, E Valencia, F Plano, F Paredes Oña, F Arancibia, F Montufar Andrade, F Morales Alava, G Cañarte Bermudez, G La Fuente Zerain, V Alanis Mirones, J Rojas Suarez, J Guzmán Torrico, J Silva, J Vergara Centeno, J C Medina, K Marín, L A Caero, L Durán Crespo, M Gómez Duque, M Játiva, R Belloni, R Romero, R Aguilera Perrogón, R Camacho Alarcón, R Camargo, S Cevallos, V Intriago Cedeño, Z Urbina Contreras, Latin American Antibiotic Use in Intensive Care Unit Group Referencia : J Chemother. 2009 Nov;21(5):527-34. DOI (Digital Object Identifier) : 10.1179/joc.2009.21.5.527 PMID : 19933044 En línea : https://www.tandfonline.com/doi/abs/10.1179/joc.2009.21.5.527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4457 Reserva
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