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Medicinal marijuana for epilepsy: a case series study / Lady Diana Ladino Malagón  

Público ISBD Título : Medicinal marijuana for epilepsy: a case series study Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Canadian Journal of Neurological Sciences Dimensiones : PDF Idioma : Inglés (eng) Palabras clave : anticonvulsant  cannabis  cannabinoids  medicinal marijuana  seizures Resumen : Objective: To describe the social, clinical and use-patterns characteristics of medicinal marijuana use among patients with epilepsy (PWEs). Methods: Eighteen PWEs with prescriptions for medicinal marijuana from a Canadian adult-epilepsy clinic were included in this study. Results: Eighteen patients had a prescription of medicinal marijuana from a total population of 800 PWEs in our center (2.2%). Mean age of patients was 30±7.4 (19-50) years. Twelve (67%) patients were males. Eleven (61%) patients had drug resistant epilepsy. Eleven (61%) patients suffered a psychiatric comorbidity and reported the use of illicit substances or heavy alcohol or tobacco consumption. Only two (11%) patients were married; the rest of patients (89%) were single or divorced. The drug use pattern was similar among patients. All patients asked for marijuana permission in the epilepsy clinic. Most (83%) had a previous history of marijuana smoking, with a mean of 6.6±3 (1-15) years. The mean consumption dose was 2.05±1.8 (0.5-8) grams per day. Ten (56%) patients reported withdrawal seizure exacerbation when they stopped the marijuana. Only two patients (11%) reported side effects, and all patients found medicinal marijuana very helpful for seizure control and improvement of mood disorder. Conclusions: PWEs using medicinal marijuana have a common profile. They are usually young single men with drug-resistant epilepsy and psychiatric comorbidity. Most used marijuana before formal prescription and all believe the drug was effective on their seizure control. Because of the concurrent use of other antiseizure medications, it is complex to estimate the actual effect of marijuana. Mención de responsabilidad : Lady Diana Ladino, Lizbeth Hernández-Ronquillo, José Francisco Téllez-Zenteno Referencia : Can J Neurol Sci. 2014 Nov;41(6):753-8 DOI (Digital Object Identifier) : 10.1017/cjn.2014.37 PMID : 25377755 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3416 Medicinal marijuana for epilepsy: a case series study [documento electrónico] / Lady Diana Ladino Malagón,  . - 2014 . -  ; PDF. Obra : Canadian Journal of Neurological Sciences Idioma : Inglés (eng) Palabras clave : anticonvulsant  cannabis  cannabinoids  medicinal marijuana  seizures Resumen : Objective: To describe the social, clinical and use-patterns characteristics of medicinal marijuana use among patients with epilepsy (PWEs). Methods: Eighteen PWEs with prescriptions for medicinal marijuana from a Canadian adult-epilepsy clinic were included in this study. Results: Eighteen patients had a prescription of medicinal marijuana from a total population of 800 PWEs in our center (2.2%). Mean age of patients was 30±7.4 (19-50) years. Twelve (67%) patients were males. Eleven (61%) patients had drug resistant epilepsy. Eleven (61%) patients suffered a psychiatric comorbidity and reported the use of illicit substances or heavy alcohol or tobacco consumption. Only two (11%) patients were married; the rest of patients (89%) were single or divorced. The drug use pattern was similar among patients. All patients asked for marijuana permission in the epilepsy clinic. Most (83%) had a previous history of marijuana smoking, with a mean of 6.6±3 (1-15) years. The mean consumption dose was 2.05±1.8 (0.5-8) grams per day. Ten (56%) patients reported withdrawal seizure exacerbation when they stopped the marijuana. Only two patients (11%) reported side effects, and all patients found medicinal marijuana very helpful for seizure control and improvement of mood disorder. Conclusions: PWEs using medicinal marijuana have a common profile. They are usually young single men with drug-resistant epilepsy and psychiatric comorbidity. Most used marijuana before formal prescription and all believe the drug was effective on their seizure control. Because of the concurrent use of other antiseizure medications, it is complex to estimate the actual effect of marijuana. Mención de responsabilidad : Lady Diana Ladino, Lizbeth Hernández-Ronquillo, José Francisco Téllez-Zenteno Referencia : Can J Neurol Sci. 2014 Nov;41(6):753-8 DOI (Digital Object Identifier) : 10.1017/cjn.2014.37 PMID : 25377755 En línea : https://www.cambridge.org/core/journals/canadian-journal-of-neurological-science [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3416

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000419	AC-2014-085	Archivo digital	Producción Científica	Artículos científicos	Disponible

A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy / Lady Diana Ladino Malagón  

Público ISBD Título : A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Clinical EEG and Neuroscience Idioma : Inglés (eng) Palabras clave : Classification  epilepsy surgery  idiopathic generalized epilepsy  seizures  temporal lobe epilepsy Resumen : The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 years, with a good response to phenobarbital. At the age of 14 years, he began to experience complex partial seizures (CPS). Video-electroencephalography (video-EEG) telemetry showed the coexistence of right temporal spikes and bursts of generalized spike-wave (GSW). The ictal EEG showed a unique EEG pattern characterized by a 4- to 5-second burst of GSW followed by rhythmic delta activity over the right temporal region. A magnetic resonance image (MRI) showed right hippocampal sclerosis. The patient underwent a right temporal lobectomy that significantly improved his seizure control. He was rendered seizure free of the complex partial seizures and improvement of the GTCS. This case illustrates a very uncommon ictal EEG pattern, and shows that the decision for surgery in patients with focal drug-resistant epilepsy should not be affected by coexistent generalized epilepsy. Mención de responsabilidad : Lady Diana Ladino, Aaron Gleadow, José F Téllez-Zenteno Referencia : Clin EEG Neurosci. 2015 Apr;46(2):136-41. DOI (Digital Object Identifier) : 10.1177/1550059413516463 PMID : 24615929 En línea : https://journals.sagepub.com/doi/abs/10.1177/1550059413516463?journalCode=eegb Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3793 A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy [documento electrónico] / Lady Diana Ladino Malagón,  . - 2014. Obra : Clinical EEG and Neuroscience Idioma : Inglés (eng) Palabras clave : Classification  epilepsy surgery  idiopathic generalized epilepsy  seizures  temporal lobe epilepsy Resumen : The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 years, with a good response to phenobarbital. At the age of 14 years, he began to experience complex partial seizures (CPS). Video-electroencephalography (video-EEG) telemetry showed the coexistence of right temporal spikes and bursts of generalized spike-wave (GSW). The ictal EEG showed a unique EEG pattern characterized by a 4- to 5-second burst of GSW followed by rhythmic delta activity over the right temporal region. A magnetic resonance image (MRI) showed right hippocampal sclerosis. The patient underwent a right temporal lobectomy that significantly improved his seizure control. He was rendered seizure free of the complex partial seizures and improvement of the GTCS. This case illustrates a very uncommon ictal EEG pattern, and shows that the decision for surgery in patients with focal drug-resistant epilepsy should not be affected by coexistent generalized epilepsy. Mención de responsabilidad : Lady Diana Ladino, Aaron Gleadow, José F Téllez-Zenteno Referencia : Clin EEG Neurosci. 2015 Apr;46(2):136-41. DOI (Digital Object Identifier) : 10.1177/1550059413516463 PMID : 24615929 En línea : https://journals.sagepub.com/doi/abs/10.1177/1550059413516463?journalCode=eegb Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3793

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000368	AC-2014-034	Archivo digital	Producción Científica	Artículos científicos	Disponible