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Treatment of invasive silent somatotroph pituitary adenoma with temozolomide. Report of a case and review of the literature / Luis Vicente Syro Moreno  

Público ISBD Título : Treatment of invasive silent somatotroph pituitary adenoma with temozolomide. Report of a case and review of the literature Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2015 Títulos uniformes : Endocrine Pathology Idioma : Inglés (eng) Palabras clave : MGMT  pathology  pituitary  somatotroph adenoma  temozolomide Resumen : Improved imaging techniques have contributed to increased diagnosis of pituitary tumors. These tumor types can be microadenomas or macroadenomas and can either be functional or non-functional. Atypical or aggressive pituitary adenomas are tumors that rapidly increase in size and may invade into the suprasellar or parasellar regions. They are characterized by a Ki-67 nuclear labeling index greater than 10 %. Management of these tumors is difficult, and many recur after surgery. Temozolomide, a second generation alkylating agent, has been showing promising results in the treatment of these tumors. The patient was a 39-year-old male diagnosed with an invasive silent somatotroph pituitary macroadenoma treated with temozolomide after surgery. We present the case along with the review of the literature of the therapeutic effects of temozolomide in somatotroph macroadenomas. Mención de responsabilidad : Ali A Ghazi, Fabio Rotondo, Kalman Kovacs, Alireza Amirbaigloo, Luis V Syro, Hussein Fathalla, Antonio Di Ieva, Michael D Cusimano Referencia : Endocr Pathol. 2015 May;26(2):135-9. DOI (Digital Object Identifier) : 10.1007/s12022-015-9361-z PMID : 25716461 En línea : https://link.springer.com/article/10.1007%2Fs12022-015-9361-z Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3882 Treatment of invasive silent somatotroph pituitary adenoma with temozolomide. Report of a case and review of the literature [documento electrónico] / Luis Vicente Syro Moreno,  . - 2015. Obra : Endocrine Pathology Idioma : Inglés (eng) Palabras clave : MGMT  pathology  pituitary  somatotroph adenoma  temozolomide Resumen : Improved imaging techniques have contributed to increased diagnosis of pituitary tumors. These tumor types can be microadenomas or macroadenomas and can either be functional or non-functional. Atypical or aggressive pituitary adenomas are tumors that rapidly increase in size and may invade into the suprasellar or parasellar regions. They are characterized by a Ki-67 nuclear labeling index greater than 10 %. Management of these tumors is difficult, and many recur after surgery. Temozolomide, a second generation alkylating agent, has been showing promising results in the treatment of these tumors. The patient was a 39-year-old male diagnosed with an invasive silent somatotroph pituitary macroadenoma treated with temozolomide after surgery. We present the case along with the review of the literature of the therapeutic effects of temozolomide in somatotroph macroadenomas. Mención de responsabilidad : Ali A Ghazi, Fabio Rotondo, Kalman Kovacs, Alireza Amirbaigloo, Luis V Syro, Hussein Fathalla, Antonio Di Ieva, Michael D Cusimano Referencia : Endocr Pathol. 2015 May;26(2):135-9. DOI (Digital Object Identifier) : 10.1007/s12022-015-9361-z PMID : 25716461 En línea : https://link.springer.com/article/10.1007%2Fs12022-015-9361-z Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3882

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000462	AC-2015-015	Archivo digital	Producción Científica	Artículos científicos	Disponible

Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma / Luis Vicente Syro Moreno  

Público ISBD Título : Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2000 Títulos uniformes : Journal of Endocrinological Investigation Idioma : Inglés (eng) Palabras clave : Pituitary neoplasm  pathology  histology  immunocytochemistry  ultrastructure  acromegaly  somatotroph adenoma  gonadotroph adenoma  double adenomas  collision tumors Resumen : Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic resonance imaging demonstrated a pituitary tumor. The surgically removed sellar mass was investigated by histology, immunocytochemistry and electron microscopy. Morphologic study revealed a collision tumor; one was a somatotroph adenoma, the other a gonadotroph adenoma. Authors call attention to the difficulties in clinical, imaging and pathological diagnosis. Detailed morphologic studies are needed to establish the presence of two distinct tumors composed of two different cell types. Mención de responsabilidad : L. V. Syro, E. Horvath & Kalman Kovacs Referencia : J Endocrinol Invest. 2000 Jan;23(1):37-41. DOI (Digital Object Identifier) : 10.1007/BF03343674 PMID : 10698050 En línea : https://link.springer.com/article/10.1007/BF03343674 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4387 Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma [documento electrónico] / Luis Vicente Syro Moreno,  . - 2000. Obra : Journal of Endocrinological Investigation Idioma : Inglés (eng) Palabras clave : Pituitary neoplasm  pathology  histology  immunocytochemistry  ultrastructure  acromegaly  somatotroph adenoma  gonadotroph adenoma  double adenomas  collision tumors Resumen : Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic resonance imaging demonstrated a pituitary tumor. The surgically removed sellar mass was investigated by histology, immunocytochemistry and electron microscopy. Morphologic study revealed a collision tumor; one was a somatotroph adenoma, the other a gonadotroph adenoma. Authors call attention to the difficulties in clinical, imaging and pathological diagnosis. Detailed morphologic studies are needed to establish the presence of two distinct tumors composed of two different cell types. Mención de responsabilidad : L. V. Syro, E. Horvath & Kalman Kovacs Referencia : J Endocrinol Invest. 2000 Jan;23(1):37-41. DOI (Digital Object Identifier) : 10.1007/BF03343674 PMID : 10698050 En línea : https://link.springer.com/article/10.1007/BF03343674 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4387

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Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000887	AC-2000-002	Archivo digital	Producción Científica	Artículos científicos	Disponible