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Enlace permanente de la investigaciónRisk factors associated with drug resistant focal epilepsy in adults: A case control study / Lady Diana Ladino Malagón
Título : Risk factors associated with drug resistant focal epilepsy in adults: A case control study Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2019 Títulos uniformes : Seizure Idioma : Inglés (eng) Palabras clave : Complex partial seizure Focal seizure Intractable epilepsy Refractory epilepsy Risk factor Temporal lobe epilepsy Resumen : Purpose: Using an adult cohort of patients with focal epilepsy, we aimed to identify risk factors for development of drug-resistant epilepsy, which if identifiable would allow patients to receive appropriate counsel and earlier surgical treatment. Methods: This is a case-control study nested within a cohort, 146 adult patients with focal epilepsy were included. Definitions were used in accordance with ILAE criteria. The odds ratio and its confidence interval were calculated. We performed a logistic regression analysis. Results: Seventy-one [48.6%] patients met the criteria for drug-resistant epilepsy [cases] and 75 [51.4%] patients were controls. The mean age of patients was 44.5 ± 16.4 years. The most significant variables associated with developing drug-resistant epilepsy include younger age at diagnosis [18.75 vs. 32.2, p Mención de responsabilidad : Pragma Laboni Roy, Lizbeth Hernandez Ronquillo, Lady Diana Ladino, Jose F Tellez-Zenteno Referencia : Seizure. 2019;73:46–50. DOI (Digital Object Identifier) : 10.1016/j.seizure.2019.10.020 PMID : 31734466 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1059-1311(19)30390-5 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5081 Risk factors associated with drug resistant focal epilepsy in adults: A case control study [documento electrónico] / Lady Diana Ladino Malagón, . - 2019.
Obra : Seizure
Idioma : Inglés (eng)
Palabras clave : Complex partial seizure Focal seizure Intractable epilepsy Refractory epilepsy Risk factor Temporal lobe epilepsy Resumen : Purpose: Using an adult cohort of patients with focal epilepsy, we aimed to identify risk factors for development of drug-resistant epilepsy, which if identifiable would allow patients to receive appropriate counsel and earlier surgical treatment. Methods: This is a case-control study nested within a cohort, 146 adult patients with focal epilepsy were included. Definitions were used in accordance with ILAE criteria. The odds ratio and its confidence interval were calculated. We performed a logistic regression analysis. Results: Seventy-one [48.6%] patients met the criteria for drug-resistant epilepsy [cases] and 75 [51.4%] patients were controls. The mean age of patients was 44.5 ± 16.4 years. The most significant variables associated with developing drug-resistant epilepsy include younger age at diagnosis [18.75 vs. 32.2, p Mención de responsabilidad : Pragma Laboni Roy, Lizbeth Hernandez Ronquillo, Lady Diana Ladino, Jose F Tellez-Zenteno Referencia : Seizure. 2019;73:46–50. DOI (Digital Object Identifier) : 10.1016/j.seizure.2019.10.020 PMID : 31734466 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1059-1311(19)30390-5 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5081 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001311 AC-2020-015 Archivo digital Producción Científica Artículos científicos Disponible
Título : How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2016 Títulos uniformes : Epileptic Disorders Idioma : Inglés (eng) Palabras clave : Adult epilepsy benign temporal epilepsy mild course prognosis severe course temporal lobe epilepsy Resumen : Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy in adults and commonly requires surgical treatment. While an overwhelming preponderance of literature supports the notion that a large percentage of patients with TLE benefit from surgery, there is a paucity of outcome data on patients who demonstrate a sustained response to pharmacological treatment. In this study, we present an adult cohort of patients with TLE, with the purpose of identifying the proportion of patients with a mild course of the disease, as well as potential risk factors. A prospective cohort study of all patients with TLE assessed and followed by the Saskatchewan Epilepsy Program, from 1 March 2007 to Jan 29(th) 2014. Patients were dichotomized as having a mild (seizure freedom without surgical intervention) or severe (surgical intervention required and/or failure to achieve seizure remission) course. Descriptive statistics, odds ratios and confidence intervals were calculated to identify predictors of seizure freedom. The cohort consisted of 159 patients. Mean patient age at last follow-up visit was 46±14.4 (range: 19-88) years. Mean follow-up period was 43.4±22.6 (6 to 84) months. Forty-six patients (29%) demonstrated mild-course TLE while 113 (71%) had a severe course of TLE. Patients with a mild course of TLE were more likely to be older (p = 0.002), have late-onset epilepsy (p Mención de responsabilidad : Lizbeth Hernández-Ronquillo, Samantha Buckley, Lady Diana Ladino, Adam Wu, Farzad Moien-Afshari, Syed Aa Rizvi, Jose F Téllez-Zenteno Referencia : Epileptic Disord. 2016 Jun 1;18(2):137-47. DOI (Digital Object Identifier) : 10.1684/epd.2016.0822 PMID : 27100050 En línea : https://www.jle.com/fr/revues/epd/e-docs/how_many_adults_with_temporal_epilepsy_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3983 How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? [documento electrónico] / Lady Diana Ladino Malagón, . - 2016.
Obra : Epileptic Disorders
Idioma : Inglés (eng)
Palabras clave : Adult epilepsy benign temporal epilepsy mild course prognosis severe course temporal lobe epilepsy Resumen : Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy in adults and commonly requires surgical treatment. While an overwhelming preponderance of literature supports the notion that a large percentage of patients with TLE benefit from surgery, there is a paucity of outcome data on patients who demonstrate a sustained response to pharmacological treatment. In this study, we present an adult cohort of patients with TLE, with the purpose of identifying the proportion of patients with a mild course of the disease, as well as potential risk factors. A prospective cohort study of all patients with TLE assessed and followed by the Saskatchewan Epilepsy Program, from 1 March 2007 to Jan 29(th) 2014. Patients were dichotomized as having a mild (seizure freedom without surgical intervention) or severe (surgical intervention required and/or failure to achieve seizure remission) course. Descriptive statistics, odds ratios and confidence intervals were calculated to identify predictors of seizure freedom. The cohort consisted of 159 patients. Mean patient age at last follow-up visit was 46±14.4 (range: 19-88) years. Mean follow-up period was 43.4±22.6 (6 to 84) months. Forty-six patients (29%) demonstrated mild-course TLE while 113 (71%) had a severe course of TLE. Patients with a mild course of TLE were more likely to be older (p = 0.002), have late-onset epilepsy (p Mención de responsabilidad : Lizbeth Hernández-Ronquillo, Samantha Buckley, Lady Diana Ladino, Adam Wu, Farzad Moien-Afshari, Syed Aa Rizvi, Jose F Téllez-Zenteno Referencia : Epileptic Disord. 2016 Jun 1;18(2):137-47. DOI (Digital Object Identifier) : 10.1684/epd.2016.0822 PMID : 27100050 En línea : https://www.jle.com/fr/revues/epd/e-docs/how_many_adults_with_temporal_epilepsy_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3983 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000575 AC-2016-050 Archivo digital Producción Científica Artículos científicos Disponible
Título : A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2014 Títulos uniformes : Clinical EEG and Neuroscience Idioma : Inglés (eng) Palabras clave : Classification epilepsy surgery idiopathic generalized epilepsy seizures temporal lobe epilepsy Resumen : The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 years, with a good response to phenobarbital. At the age of 14 years, he began to experience complex partial seizures (CPS). Video-electroencephalography (video-EEG) telemetry showed the coexistence of right temporal spikes and bursts of generalized spike-wave (GSW). The ictal EEG showed a unique EEG pattern characterized by a 4- to 5-second burst of GSW followed by rhythmic delta activity over the right temporal region. A magnetic resonance image (MRI) showed right hippocampal sclerosis. The patient underwent a right temporal lobectomy that significantly improved his seizure control. He was rendered seizure free of the complex partial seizures and improvement of the GTCS. This case illustrates a very uncommon ictal EEG pattern, and shows that the decision for surgery in patients with focal drug-resistant epilepsy should not be affected by coexistent generalized epilepsy. Mención de responsabilidad : Lady Diana Ladino, Aaron Gleadow, José F Téllez-Zenteno Referencia : Clin EEG Neurosci. 2015 Apr;46(2):136-41. DOI (Digital Object Identifier) : 10.1177/1550059413516463 PMID : 24615929 En línea : https://journals.sagepub.com/doi/abs/10.1177/1550059413516463?journalCode=eegb Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3793 A unique ictal EEG pattern in a patient with the coexistence of generalized and focal epilepsy [documento electrónico] / Lady Diana Ladino Malagón, . - 2014.
Obra : Clinical EEG and Neuroscience
Idioma : Inglés (eng)
Palabras clave : Classification epilepsy surgery idiopathic generalized epilepsy seizures temporal lobe epilepsy Resumen : The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 years, with a good response to phenobarbital. At the age of 14 years, he began to experience complex partial seizures (CPS). Video-electroencephalography (video-EEG) telemetry showed the coexistence of right temporal spikes and bursts of generalized spike-wave (GSW). The ictal EEG showed a unique EEG pattern characterized by a 4- to 5-second burst of GSW followed by rhythmic delta activity over the right temporal region. A magnetic resonance image (MRI) showed right hippocampal sclerosis. The patient underwent a right temporal lobectomy that significantly improved his seizure control. He was rendered seizure free of the complex partial seizures and improvement of the GTCS. This case illustrates a very uncommon ictal EEG pattern, and shows that the decision for surgery in patients with focal drug-resistant epilepsy should not be affected by coexistent generalized epilepsy. Mención de responsabilidad : Lady Diana Ladino, Aaron Gleadow, José F Téllez-Zenteno Referencia : Clin EEG Neurosci. 2015 Apr;46(2):136-41. DOI (Digital Object Identifier) : 10.1177/1550059413516463 PMID : 24615929 En línea : https://journals.sagepub.com/doi/abs/10.1177/1550059413516463?journalCode=eegb Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3793 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000368 AC-2014-034 Archivo digital Producción Científica Artículos científicos Disponible
