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Colombian multicentric study on epidemiology of diabetic ketoacidosis in children with type 1 diabetes mellitus / Carolina Jaramillo Arango ; Mauricio Fernández Laverde
Título : Colombian multicentric study on epidemiology of diabetic ketoacidosis in children with type 1 diabetes mellitus Tipo de documento : documento electrónico Autores : Carolina Jaramillo Arango, ; Mauricio Fernández Laverde, Fecha de publicación : 2017 Títulos uniformes : Endocrinology and Metabolism International Journal Idioma : Inglés (eng) Palabras clave : Type 1 diabetes mellitus Diabetic ketoacidosis Risk factors Pediatric intensive care units Epidemiology Multicenter studies Resumen : Background: Type 1 diabetes is a growing disease worldwide, where ketoacidosis is a serious cause commonly resulting in hospitalization. Little is known regarding the epidemiology of the development of ketoacidosis in Colombian children with a known diagnosis of diabetes. Objective: To describe the epidemiological profile of children with type 1 diabetes and ketoacidosis diagnosis. Settings: Using the online survey, http://www.e-encuesta.com/answer.do?testid=cRctXSlVSLk, seven pediatric intensive care units of the four main cities throughout the country reported epidemiological data of the patients that were admitted with episodes of ketoacidosis other than diabetes debut, between May of 2014 and May of 2016. Measurement and main results: Fifty-two events of diabetic ketoacidosis in 47 patients between ages 3 and 17 were included. The patients had mean glycosylated hemoglobin of 12% (SD: 2.9) and the median insulin dose used was 0.91 (IQR 0.74 – 1.2 UI/kg). One hundred percent of patients belonged to middle and low socioeconomic classes, 98.1% of patients were insured by the health care system, and 27.4% of patients did not have the necessary supplies for glucose control. Conclusion: The glycosylated hemoglobin levels can evidence that diabetic ketoacidosis patients were generally not well controlled prior to admission. The most common precipitating factors of diabetic ketoacidosis were the low adherence to treatment and infections. Patients must be informed about the importance of adherence to treatment and how to adjust insulin on sick days; the health care system must ensure patients have the supplies necessary for optimal diabetes control. Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika P López-Alarcón, Juan C Jaramillo Bustamante, Mauricio Fernández-Laverde, Rosalba Pardo Carrero, Alejandro Marín-Agudelo Referencia : Endocrinol Metab Int J. 2017;5(2):205-9 DOI (Digital Object Identifier) : 10.15406/emij.2017.05.00118 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/EMIJ-05-00118.php Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4057 Colombian multicentric study on epidemiology of diabetic ketoacidosis in children with type 1 diabetes mellitus [documento electrónico] / Carolina Jaramillo Arango, ; Mauricio Fernández Laverde, . - 2017.
Obra : Endocrinology and Metabolism International Journal
Idioma : Inglés (eng)
Palabras clave : Type 1 diabetes mellitus Diabetic ketoacidosis Risk factors Pediatric intensive care units Epidemiology Multicenter studies Resumen : Background: Type 1 diabetes is a growing disease worldwide, where ketoacidosis is a serious cause commonly resulting in hospitalization. Little is known regarding the epidemiology of the development of ketoacidosis in Colombian children with a known diagnosis of diabetes. Objective: To describe the epidemiological profile of children with type 1 diabetes and ketoacidosis diagnosis. Settings: Using the online survey, http://www.e-encuesta.com/answer.do?testid=cRctXSlVSLk, seven pediatric intensive care units of the four main cities throughout the country reported epidemiological data of the patients that were admitted with episodes of ketoacidosis other than diabetes debut, between May of 2014 and May of 2016. Measurement and main results: Fifty-two events of diabetic ketoacidosis in 47 patients between ages 3 and 17 were included. The patients had mean glycosylated hemoglobin of 12% (SD: 2.9) and the median insulin dose used was 0.91 (IQR 0.74 – 1.2 UI/kg). One hundred percent of patients belonged to middle and low socioeconomic classes, 98.1% of patients were insured by the health care system, and 27.4% of patients did not have the necessary supplies for glucose control. Conclusion: The glycosylated hemoglobin levels can evidence that diabetic ketoacidosis patients were generally not well controlled prior to admission. The most common precipitating factors of diabetic ketoacidosis were the low adherence to treatment and infections. Patients must be informed about the importance of adherence to treatment and how to adjust insulin on sick days; the health care system must ensure patients have the supplies necessary for optimal diabetes control. Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika P López-Alarcón, Juan C Jaramillo Bustamante, Mauricio Fernández-Laverde, Rosalba Pardo Carrero, Alejandro Marín-Agudelo Referencia : Endocrinol Metab Int J. 2017;5(2):205-9 DOI (Digital Object Identifier) : 10.15406/emij.2017.05.00118 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/EMIJ-05-00118.php Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4057 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000657 AC-2017-046 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2017-046.pdfAdobe Acrobat PDF Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus / Alejandro Daniel Velásquez Urzola
Título : Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus Tipo de documento : documento electrónico Autores : Alejandro Daniel Velásquez Urzola, Fecha de publicación : 2006 Títulos uniformes : Journal of Autoimmunity Idioma : Inglés (eng) Palabras clave : Aggregation autoimmunity type 1 diabetes mellitus hypothyroidism genetics Resumen : We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] 1⁄4 1.74e9.0, p 1⁄4 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI 1⁄4 1.64e7.73, p 1⁄4 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. Mención de responsabilidad : Juan-Manuel Anaya, John Castiblanco, Gabriel J Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D Angel, Patricia Vega, Alvaro Arango Referencia : J Autoimmun. 2006 May;26(3):208-14. DOI (Digital Object Identifier) : 10.1016/j.jaut.2006.01.001 PMID : 16503115 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0896841106000096 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3439 Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus [documento electrónico] / Alejandro Daniel Velásquez Urzola, . - 2006.
Obra : Journal of Autoimmunity
Idioma : Inglés (eng)
Palabras clave : Aggregation autoimmunity type 1 diabetes mellitus hypothyroidism genetics Resumen : We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] 1⁄4 1.74e9.0, p 1⁄4 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI 1⁄4 1.64e7.73, p 1⁄4 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. Mención de responsabilidad : Juan-Manuel Anaya, John Castiblanco, Gabriel J Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D Angel, Patricia Vega, Alvaro Arango Referencia : J Autoimmun. 2006 May;26(3):208-14. DOI (Digital Object Identifier) : 10.1016/j.jaut.2006.01.001 PMID : 16503115 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0896841106000096 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3439 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000006 AC-2006-001 Archivo digital Producción Científica Artículos científicos Disponible