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Forced normalization after turning off vagus nerve stimulation in Lennox-Gastaut syndrome / Lady Diana Ladino Malagón
Título : Forced normalization after turning off vagus nerve stimulation in Lennox-Gastaut syndrome Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2019 Títulos uniformes : Epilepsy & Behavior Case Reports Idioma : Inglés (eng) Palabras clave : ACTH adrenocorticotropic hormone ASD anti-seizure drug EEG electroencephalography FN forced normalization Forced normalization LGS Lennox Gastaut syndrome VNS vagus nerve stimulation Vagus nerve stimulation Resumen : Forced normalization is the development of psychiatric symptoms in a patient experiencing remission of seizures. We present a case of Lennox Gastaut syndrome in which forced normalization developed after vagus nerve stimulation was stopped. The patient had drug resistant epilepsy and failed anti-seizure drugs, vagus nerve stimulation, and a partial callosotomy. The patient had multiple types of seizures including drop attacks, absences, and tonic-clonic seizures. He tried vagus nerve stimulation for two years without success. Forced normalization developed after the vagus nerve stimulator was turned off. This is the first case to our knowledge to describe forced normalization after turning off the vagus nerve stimulator. Mención de responsabilidad : Sydney Lee, Alyssa Denton, Lady Diana Ladino, Karen Waterhouse, Aleksander Vitali, Jose Francisco Tellez-Zenteno Referencia : Epilepsy Behav Case Rep. 2019 Jan 27;11:81-83 DOI (Digital Object Identifier) : 10.1016/j.ebcr.2019.01.004 PMID : 30788214 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2213-3232(18)30177-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4260 Forced normalization after turning off vagus nerve stimulation in Lennox-Gastaut syndrome [documento electrónico] / Lady Diana Ladino Malagón, . - 2019.
Obra : Epilepsy & Behavior Case Reports
Idioma : Inglés (eng)
Palabras clave : ACTH adrenocorticotropic hormone ASD anti-seizure drug EEG electroencephalography FN forced normalization Forced normalization LGS Lennox Gastaut syndrome VNS vagus nerve stimulation Vagus nerve stimulation Resumen : Forced normalization is the development of psychiatric symptoms in a patient experiencing remission of seizures. We present a case of Lennox Gastaut syndrome in which forced normalization developed after vagus nerve stimulation was stopped. The patient had drug resistant epilepsy and failed anti-seizure drugs, vagus nerve stimulation, and a partial callosotomy. The patient had multiple types of seizures including drop attacks, absences, and tonic-clonic seizures. He tried vagus nerve stimulation for two years without success. Forced normalization developed after the vagus nerve stimulator was turned off. This is the first case to our knowledge to describe forced normalization after turning off the vagus nerve stimulator. Mención de responsabilidad : Sydney Lee, Alyssa Denton, Lady Diana Ladino, Karen Waterhouse, Aleksander Vitali, Jose Francisco Tellez-Zenteno Referencia : Epilepsy Behav Case Rep. 2019 Jan 27;11:81-83 DOI (Digital Object Identifier) : 10.1016/j.ebcr.2019.01.004 PMID : 30788214 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2213-3232(18)30177-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4260 Reserva
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Título : Forced normalization: A systematic review Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2019 Títulos uniformes : Epilepsia Idioma : Inglés (eng) Palabras clave : Alternative psychosis antiepileptic drugs dissociation epilepsy surgery limbic system vagus nerve stimulation Resumen : Objective: Forced normalization (FN) is an intriguing phenomenon characterized by the emergence of psychiatric disturbances following the establishment of seizure control or reduction in the epileptic activity in a patient with previous uncontrolled epilepsy. We aim to describe the clinical characteristics of the condition. Methods: We conducted a systematic review on MEDLINE, EMBASE, Cochrane, and Scielo from January 1953 to January 2018. Clinical, electrographic, and imaging data were gathered. We considered all outcomes in children and adults. We performed no meta‐analyses due to the limited available data. Results: Of 2606 abstracts identified, 36 fulfilled the FN diagnostic criteria; 193 FN episodes were evaluated and 77 of them were analyzed extensively. Sixty percent of cases were female. Mean age ± standard deviation (SD) was 28.3 ± 14.2 years. The majority of patients had focal (80%) symptomatic (44%) epilepsy. Most patients reported a high ictal frequency (58%) and were on polytherapy (51%). Patients presented psychosis (86.4%), mood disorders (25.8%), and dissociation (4.5%) as the main manifestations. In the psychosis group, persecutory (52.6%) and reference (47.3%) delusions were frequent. FN was provoked by an antiepileptic drug (AED) (48.5%) mainly levetiracetam, epilepsy surgery (31.8%), or vagus nerve stimulation (13.6%). Treatment was homogeneous including anticonvulsant withdrawal (47%) or taper (25%); antipsychotics were initiated in the majority of cases (73%). Psychiatric symptoms were partially controlled in 35%, with complete resolution of symptoms in the remaining 65% of cases. The majority of patients (87%) with AED trigger and withdrawal presented complete resolution of symptoms in comparison to 28.5% of patients triggered by surgery. Significance: Forced normalization is an entity whose pathophysiology remains uncertain. Antipsychotic drug use does not predict complete resolution of psychiatric symptoms in comparison with AED withdrawal. Although there is a positive response to treatment in patients with FN triggered by drugs, the prognosis is obscure in patients with surgery triggered FN. Mención de responsabilidad : Yamile Calle-López, Lady Diana Ladino, Vanessa Benjumea-Cuartas, Diana Marcela Castrillón-Velilla, José Francisco Téllez-Zenteno, Peter Wolf Referencia : Epilepsia. 2019 Aug;60(8):1610-1618. DOI (Digital Object Identifier) : 10.1111/epi.16276 PMID : 31260102 En línea : https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.16276 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4242 Forced normalization: A systematic review [documento electrónico] / Lady Diana Ladino Malagón, . - 2019.
Obra : Epilepsia
Idioma : Inglés (eng)
Palabras clave : Alternative psychosis antiepileptic drugs dissociation epilepsy surgery limbic system vagus nerve stimulation Resumen : Objective: Forced normalization (FN) is an intriguing phenomenon characterized by the emergence of psychiatric disturbances following the establishment of seizure control or reduction in the epileptic activity in a patient with previous uncontrolled epilepsy. We aim to describe the clinical characteristics of the condition. Methods: We conducted a systematic review on MEDLINE, EMBASE, Cochrane, and Scielo from January 1953 to January 2018. Clinical, electrographic, and imaging data were gathered. We considered all outcomes in children and adults. We performed no meta‐analyses due to the limited available data. Results: Of 2606 abstracts identified, 36 fulfilled the FN diagnostic criteria; 193 FN episodes were evaluated and 77 of them were analyzed extensively. Sixty percent of cases were female. Mean age ± standard deviation (SD) was 28.3 ± 14.2 years. The majority of patients had focal (80%) symptomatic (44%) epilepsy. Most patients reported a high ictal frequency (58%) and were on polytherapy (51%). Patients presented psychosis (86.4%), mood disorders (25.8%), and dissociation (4.5%) as the main manifestations. In the psychosis group, persecutory (52.6%) and reference (47.3%) delusions were frequent. FN was provoked by an antiepileptic drug (AED) (48.5%) mainly levetiracetam, epilepsy surgery (31.8%), or vagus nerve stimulation (13.6%). Treatment was homogeneous including anticonvulsant withdrawal (47%) or taper (25%); antipsychotics were initiated in the majority of cases (73%). Psychiatric symptoms were partially controlled in 35%, with complete resolution of symptoms in the remaining 65% of cases. The majority of patients (87%) with AED trigger and withdrawal presented complete resolution of symptoms in comparison to 28.5% of patients triggered by surgery. Significance: Forced normalization is an entity whose pathophysiology remains uncertain. Antipsychotic drug use does not predict complete resolution of psychiatric symptoms in comparison with AED withdrawal. Although there is a positive response to treatment in patients with FN triggered by drugs, the prognosis is obscure in patients with surgery triggered FN. Mención de responsabilidad : Yamile Calle-López, Lady Diana Ladino, Vanessa Benjumea-Cuartas, Diana Marcela Castrillón-Velilla, José Francisco Téllez-Zenteno, Peter Wolf Referencia : Epilepsia. 2019 Aug;60(8):1610-1618. DOI (Digital Object Identifier) : 10.1111/epi.16276 PMID : 31260102 En línea : https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.16276 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4242 Reserva
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