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Vasculogenic Mimicry in Clinically Non-functioning Pituitary Adenomas : a Histologic Study / Luis Vicente Syro Moreno
Título : Vasculogenic Mimicry in Clinically Non-functioning Pituitary Adenomas : a Histologic Study Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2017 Títulos uniformes : Pathology and Oncology Research Idioma : Inglés (eng) Palabras clave : Biomarkers pathology pituitary adenoma microvascularity vasculogenic mimicry Resumen : The term “vasculogenic mimicry” (VM) refers to the phenomenon in which vascular-like channels, which are not lined by endothelial cells, are formed in tumors. Since its discovery in 1999, it has been observed in several tumor types and is proposed to provide blood perfusion to tumors in absence of co-apted or neo-angiogenic blood vessels. Pituitary tumors are generally slow growing, benign adenomas which are less vascularized than the normal pituitary gland. To date, VM in pituitary adenomas has not been described. In this histological study, we assessed the presence of VM in a series of surgically resected clinically non-functioning pituitary adenomas (NFPAs) using CD34 and Periodic Acid-Schiff (PAS) double staining. To identify VM, slides were assessed for the presence of CD34-negative and PAS-positive channels indicating that they were not lined by endothelial cells. The histological staining pattern suggestive of VM was noted in 22/49 (44.9%) of the specimens studied. VM was observed in both recurring and non-recurring NFPAs. The incidence of VM present varied from case to case and within groups. There was no association between the presence of VM and gender, tumor size, Ki-67 index, recurrence or cavernous sinus invasion. VM was not noted in cases of non-tumorous pituitaries. Our findings suggest the existence of a complementary perfusion system in pituitary adenomas, implying potential clinical implications with respect to response to therapy and clinical course. Further research is warranted to confirm the presence of VM in pituitary adenomas to elucidate its clinical relevance in patients diagnosed with a pituitary adenoma. Mención de responsabilidad : Joseph Di Michele, Fabio Rotondo, Kalman Kovacs, Luis V Syro, George M Yousef, Michael D Cusimano, Antonio Di Ieva Referencia : Pathol Oncol Res. 2017 Oct;23(4):803-809. DOI (Digital Object Identifier) : 10.1007/s12253-017-0196-4 PMID : 28084580 En línea : https://link.springer.com/article/10.1007%2Fs12253-017-0196-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4030 Vasculogenic Mimicry in Clinically Non-functioning Pituitary Adenomas : a Histologic Study [documento electrónico] / Luis Vicente Syro Moreno, . - 2017.
Obra : Pathology and Oncology Research
Idioma : Inglés (eng)
Palabras clave : Biomarkers pathology pituitary adenoma microvascularity vasculogenic mimicry Resumen : The term “vasculogenic mimicry” (VM) refers to the phenomenon in which vascular-like channels, which are not lined by endothelial cells, are formed in tumors. Since its discovery in 1999, it has been observed in several tumor types and is proposed to provide blood perfusion to tumors in absence of co-apted or neo-angiogenic blood vessels. Pituitary tumors are generally slow growing, benign adenomas which are less vascularized than the normal pituitary gland. To date, VM in pituitary adenomas has not been described. In this histological study, we assessed the presence of VM in a series of surgically resected clinically non-functioning pituitary adenomas (NFPAs) using CD34 and Periodic Acid-Schiff (PAS) double staining. To identify VM, slides were assessed for the presence of CD34-negative and PAS-positive channels indicating that they were not lined by endothelial cells. The histological staining pattern suggestive of VM was noted in 22/49 (44.9%) of the specimens studied. VM was observed in both recurring and non-recurring NFPAs. The incidence of VM present varied from case to case and within groups. There was no association between the presence of VM and gender, tumor size, Ki-67 index, recurrence or cavernous sinus invasion. VM was not noted in cases of non-tumorous pituitaries. Our findings suggest the existence of a complementary perfusion system in pituitary adenomas, implying potential clinical implications with respect to response to therapy and clinical course. Further research is warranted to confirm the presence of VM in pituitary adenomas to elucidate its clinical relevance in patients diagnosed with a pituitary adenoma. Mención de responsabilidad : Joseph Di Michele, Fabio Rotondo, Kalman Kovacs, Luis V Syro, George M Yousef, Michael D Cusimano, Antonio Di Ieva Referencia : Pathol Oncol Res. 2017 Oct;23(4):803-809. DOI (Digital Object Identifier) : 10.1007/s12253-017-0196-4 PMID : 28084580 En línea : https://link.springer.com/article/10.1007%2Fs12253-017-0196-4 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4030 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000625 AC-2017-014 Archivo digital Producción Científica Artículos científicos Disponible
Título : Pituitary adenoma with peliosis: a report of two cases Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2009 Títulos uniformes : Endocrine Pathology Idioma : Inglés (eng) Palabras clave : Oncology pathology peliosis pituitary pituitary neoplasm vasculogenic mimicry Resumen : Peliosis is characterised by multiple blood-filled lakes or cavities within parenchymatous organs. Typically found in the liver, spleen, bone marrow and lymph nodes, it has also been described in other organs such as lungs, kidneys, parathyroids and pancreas. The mechanism responsible for the development of peliosis remains unknown. (1) A 69 year-old man with a 6-year history of acromegaly underwent transsphenoidal surgery for pituitary adenoma. Morphologic findings demonstrated a plurimorphous plurihormonal pituitary adenoma consisting of somatotrophs, lactotrophs and mammosomatotrophs. The tumor contained several blood-filled cavities characteristic of peliosis. (2) A 61-year-old man with a prolactin-producing pituitary adenoma who underwent transsphenoidal surgery. In the tumor, peliosis was noted. Peliosis in a pituitary adenoma is an intriguing finding. The question arises whether it represents vasculogenic mimicry. Mención de responsabilidad : Safraz Mohammed, Luis V. Syro, Bernd W. Scheithauer, Alberto Abad, Humberto Uribe, Fabio Rotondo, Eva Horvath, Michael Cusimano & Kalman Kovacs Referencia : Endocr Pathol. 2009 Spring;20(1):41-5. DOI (Digital Object Identifier) : 10.1007/s12022-008-9056-9 PMID : 19089655 En línea : https://link.springer.com/article/10.1007/s12022-008-9056-9 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3474 Pituitary adenoma with peliosis: a report of two cases [documento electrónico] / Luis Vicente Syro Moreno, . - 2009.
Obra : Endocrine Pathology
Idioma : Inglés (eng)
Palabras clave : Oncology pathology peliosis pituitary pituitary neoplasm vasculogenic mimicry Resumen : Peliosis is characterised by multiple blood-filled lakes or cavities within parenchymatous organs. Typically found in the liver, spleen, bone marrow and lymph nodes, it has also been described in other organs such as lungs, kidneys, parathyroids and pancreas. The mechanism responsible for the development of peliosis remains unknown. (1) A 69 year-old man with a 6-year history of acromegaly underwent transsphenoidal surgery for pituitary adenoma. Morphologic findings demonstrated a plurimorphous plurihormonal pituitary adenoma consisting of somatotrophs, lactotrophs and mammosomatotrophs. The tumor contained several blood-filled cavities characteristic of peliosis. (2) A 61-year-old man with a prolactin-producing pituitary adenoma who underwent transsphenoidal surgery. In the tumor, peliosis was noted. Peliosis in a pituitary adenoma is an intriguing finding. The question arises whether it represents vasculogenic mimicry. Mención de responsabilidad : Safraz Mohammed, Luis V. Syro, Bernd W. Scheithauer, Alberto Abad, Humberto Uribe, Fabio Rotondo, Eva Horvath, Michael Cusimano & Kalman Kovacs Referencia : Endocr Pathol. 2009 Spring;20(1):41-5. DOI (Digital Object Identifier) : 10.1007/s12022-008-9056-9 PMID : 19089655 En línea : https://link.springer.com/article/10.1007/s12022-008-9056-9 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3474 Ejemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000042 AC-2009-004 Archivo digital Producción Científica Artículos científicos Consulta en sala
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