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Virulence of Paracoccidioides brasiliensis: The influence of in vitro passage and storage / Ángela Restrepo Moreno
Título : Virulence of Paracoccidioides brasiliensis: The influence of in vitro passage and storage Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, Fecha de publicación : 1990 Títulos uniformes : Mycopathologia Idioma : Inglés (eng) Palabras clave : Paracoccidioides brasiliensis Paracoccidioidomycosis passage in vitro virulence Resumen : Stability of virulence in P. brasiliensis isolates was studied with respect to the in vitro culture history and methods used for storage. Virulence in yeast-form P. brasiliensis isolates was tested in a chronic pulmonary murine model of paracoccidioidomycosis where progression of disease was quantitated in terms of colony forming units recoverable from lungs. Four isolates of P. brasiliensis, including recently isolated from patients or experimental animals, caused chronic progressive disease. Two isolates with a history of subculturing showed attenuation by causing resolving but chronic disease. An attenuated isolate became avirulent subsequent to 15 more years of subculturing. These findings suggest that virulence of P. brasiliensis can be attenuated or lost subsequent to cycles of subculturing over long periods. Our data suggest that the use of fresh P. brasiliensis isolates may be needed to provide reproducible virulence for experimental systems. Mención de responsabilidad : Elmer Brummer, Angela Restrepo, Linda H. Hanson & David A. Stevens Referencia : Mycopathologia. 1990 Jan;109(1):13-7. DOI (Digital Object Identifier) : 10.1007/BF00437001 PMID : 2139178 En línea : https://link.springer.com/article/10.1007%2FBF00437001 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4358 Virulence of Paracoccidioides brasiliensis: The influence of in vitro passage and storage [documento electrónico] / Ángela Restrepo Moreno, . - 1990.
Obra : Mycopathologia
Idioma : Inglés (eng)
Palabras clave : Paracoccidioides brasiliensis Paracoccidioidomycosis passage in vitro virulence Resumen : Stability of virulence in P. brasiliensis isolates was studied with respect to the in vitro culture history and methods used for storage. Virulence in yeast-form P. brasiliensis isolates was tested in a chronic pulmonary murine model of paracoccidioidomycosis where progression of disease was quantitated in terms of colony forming units recoverable from lungs. Four isolates of P. brasiliensis, including recently isolated from patients or experimental animals, caused chronic progressive disease. Two isolates with a history of subculturing showed attenuation by causing resolving but chronic disease. An attenuated isolate became avirulent subsequent to 15 more years of subculturing. These findings suggest that virulence of P. brasiliensis can be attenuated or lost subsequent to cycles of subculturing over long periods. Our data suggest that the use of fresh P. brasiliensis isolates may be needed to provide reproducible virulence for experimental systems. Mención de responsabilidad : Elmer Brummer, Angela Restrepo, Linda H. Hanson & David A. Stevens Referencia : Mycopathologia. 1990 Jan;109(1):13-7. DOI (Digital Object Identifier) : 10.1007/BF00437001 PMID : 2139178 En línea : https://link.springer.com/article/10.1007%2FBF00437001 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4358 Reserva
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