Título : |
Management of antiepileptic drugs following epilepsy surgery: a meta-analysis |
Tipo de documento : |
documento electrónico |
Autores : |
Lady Diana Ladino Malagón, |
Fecha de publicación : |
2014 |
Títulos uniformes : |
Epilepsy Research
|
Idioma : |
Inglés (eng) |
Palabras clave : |
Epilepsy surgery discontinuation drug-resistant AEDs seizure recurrence withdrawal |
Resumen : |
Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p |
Mención de responsabilidad : |
Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno |
Referencia : |
Epilepsy Res. 2014;108(4):765-74. |
DOI (Digital Object Identifier) : |
10.1016/j.eplepsyres.2014.01.024 |
PMID : |
24613746 |
En línea : |
https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 |
Management of antiepileptic drugs following epilepsy surgery: a meta-analysis [documento electrónico] / Lady Diana Ladino Malagón, . - 2014. Obra : Epilepsy ResearchIdioma : Inglés ( eng) Palabras clave : |
Epilepsy surgery discontinuation drug-resistant AEDs seizure recurrence withdrawal |
Resumen : |
Objective: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to provide evidence-based estimates of results on AEDs discontinuation after ES. Methods: We searched MEDLINE and Embase using Medical Subject Headings and keywords related to AEDs discontinuation after ES. Two reviewers independently applied the following inclusion criteria: original published research that directly compared seizure outcomes in patients having or not AEDs discontinuation after ES. Two investigators independently extracted data, resolving disagreements through discussion. A random and fixed-effect model was used to derive a pooled odds ratio (OR) for either seizure recurrence in both groups. Results: Of 257 abstracts initially identified by the search, 57 were reviewed as full text. Sixteen articles fulfilled eligibility criteria and described outcomes in 1456 patients with AEDs discontinuation and 685 patients with no discontinuation. The odds of having seizure recurrence after AEDs discontinuation was 0.39 times lower in patients with attempted discontinuation after surgery (OR 0.39, CI 95% 0.300—0.507, p |
Mención de responsabilidad : |
Lady D Ladino, Lizbeth Hernández-Ronquillo, José F Téllez-Zenteno |
Referencia : |
Epilepsy Res. 2014;108(4):765-74. |
DOI (Digital Object Identifier) : |
10.1016/j.eplepsyres.2014.01.024 |
PMID : |
24613746 |
En línea : |
https://linkinghub.elsevier.com/retrieve/pii/S0920121114000394 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3792 |
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