Título : |
The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis |
Tipo de documento : |
documento electrónico |
Autores : |
Mónica Rosa Trujillo Honeysberg, |
Fecha de publicación : |
1997 |
Títulos uniformes : |
Journal of Infectious Diseases
|
Idioma : |
Inglés (eng) |
Resumen : |
Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 mg significantly reduced tumor necrosis factor-α (TNF-α) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined. |
Mención de responsabilidad : |
María M. París, Sheila M. Hickey, Mónica Trujillo, Amina Ahmed, Kurt Olsen, George H. McCracken, Jr. |
Referencia : |
J Infect Dis. 1997 Nov;176(5):1239-46. |
DOI (Digital Object Identifier) : |
10.1086/514118 |
PMID : |
9359724 |
En línea : |
https://academic.oup.com/jid/article/176/5/1239/831438 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4380 |
The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 1997. Obra : Journal of Infectious DiseasesIdioma : Inglés ( eng) Resumen : |
Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 mg significantly reduced tumor necrosis factor-α (TNF-α) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined. |
Mención de responsabilidad : |
María M. París, Sheila M. Hickey, Mónica Trujillo, Amina Ahmed, Kurt Olsen, George H. McCracken, Jr. |
Referencia : |
J Infect Dis. 1997 Nov;176(5):1239-46. |
DOI (Digital Object Identifier) : |
10.1086/514118 |
PMID : |
9359724 |
En línea : |
https://academic.oup.com/jid/article/176/5/1239/831438 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4380 |
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