Título : |
Effect of temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma |
Tipo de documento : |
documento electrónico |
Autores : |
Luis Vicente Syro Moreno, |
Fecha de publicación : |
2009 |
Títulos uniformes : |
Hormones
|
Idioma : |
Inglés (eng) |
Palabras clave : |
MGMT Neoplasm Pathology Pituitary Temozolomide |
Resumen : |
The patient was a 70-year-old man with a recurrent pituitary tumor. Three surgeries were performed but the tumor recurred. Based on histologic, immunohistochemical and ultrastructural studies, the diagnosis of oncocytic gonadotrophic pituitary adenoma was made. The tumor was a macroadenoma partly immunopositive for LH. Immunohistochemistry for O6 Methylguanine-DNA Methyl-Transferase (MGMT) showed an admixture of immunopositive and immunonegative cells. After recurrence following operations, the patient was treated with Temozolomide, an imidazotetrazine derivative, DNA-alkylating drug. Following Temozolomide administration the MRI demonstrated significant tumor necrosis. A few months later, the patient died of massive pulmonary embolism. No autopsy was performed. The present case indicates that benign, typically slow-growing pituitary adenomas of oncocytic gonadotrophic type may respond to Temozolomide even when the tumor consists of an admixture of MGMT immunopositive and immunonegative cells. |
Mención de responsabilidad : |
Luis V Syro, Bernd W Scheithauer, Leon D Ortiz, Camilo E Fadul, Eva Horvath, Fabio Rotondo, Kalman Kovacs |
Referencia : |
Hormones (Athens). 2009 Oct-Dec;8(4):303-6. |
DOI (Digital Object Identifier) : |
10.14310/horm.2002.1247 |
PMID : |
20045804 |
En línea : |
https://link.springer.com/article/10.14310/horm.2002.1247 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4443 |
Effect of temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma [documento electrónico] / Luis Vicente Syro Moreno, . - 2009. Obra : HormonesIdioma : Inglés ( eng) Palabras clave : |
MGMT Neoplasm Pathology Pituitary Temozolomide |
Resumen : |
The patient was a 70-year-old man with a recurrent pituitary tumor. Three surgeries were performed but the tumor recurred. Based on histologic, immunohistochemical and ultrastructural studies, the diagnosis of oncocytic gonadotrophic pituitary adenoma was made. The tumor was a macroadenoma partly immunopositive for LH. Immunohistochemistry for O6 Methylguanine-DNA Methyl-Transferase (MGMT) showed an admixture of immunopositive and immunonegative cells. After recurrence following operations, the patient was treated with Temozolomide, an imidazotetrazine derivative, DNA-alkylating drug. Following Temozolomide administration the MRI demonstrated significant tumor necrosis. A few months later, the patient died of massive pulmonary embolism. No autopsy was performed. The present case indicates that benign, typically slow-growing pituitary adenomas of oncocytic gonadotrophic type may respond to Temozolomide even when the tumor consists of an admixture of MGMT immunopositive and immunonegative cells. |
Mención de responsabilidad : |
Luis V Syro, Bernd W Scheithauer, Leon D Ortiz, Camilo E Fadul, Eva Horvath, Fabio Rotondo, Kalman Kovacs |
Referencia : |
Hormones (Athens). 2009 Oct-Dec;8(4):303-6. |
DOI (Digital Object Identifier) : |
10.14310/horm.2002.1247 |
PMID : |
20045804 |
En línea : |
https://link.springer.com/article/10.14310/horm.2002.1247 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4443 |
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