Título : |
Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes |
Tipo de documento : |
documento electrónico |
Autores : |
Luis Vicente Syro Moreno, |
Fecha de publicación : |
2010 |
Títulos uniformes : |
Neoplasma
|
Idioma : |
Inglés (eng) |
Palabras clave : |
immunohistochemistry endoglin CD34 microvascular density angiogenesis pituitary |
Resumen : |
Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. |
Mención de responsabilidad : |
F Rotondo, S Sharma, B W Scheithauer, E Horvath, L V Syro, M Cusimano, F Nassiri, G M Yousef, K Kovacs |
Referencia : |
Neoplasma. 2010;57(6):590-3. |
DOI (Digital Object Identifier) : |
10.4149/neo_2010_06_590 |
PMID : |
20845998 |
En línea : |
http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&produ [...] |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4470 |
Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes [documento electrónico] / Luis Vicente Syro Moreno, . - 2010. Obra : NeoplasmaIdioma : Inglés ( eng) Palabras clave : |
immunohistochemistry endoglin CD34 microvascular density angiogenesis pituitary |
Resumen : |
Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. |
Mención de responsabilidad : |
F Rotondo, S Sharma, B W Scheithauer, E Horvath, L V Syro, M Cusimano, F Nassiri, G M Yousef, K Kovacs |
Referencia : |
Neoplasma. 2010;57(6):590-3. |
DOI (Digital Object Identifier) : |
10.4149/neo_2010_06_590 |
PMID : |
20845998 |
En línea : |
http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&produ [...] |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4470 |
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