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Etiología y clínica de la ira baja adquirida en la comunidad en 100 niños estudiados a nivel hospitalario / Hugo Trujillo Soto ; Jaime Robledo ; David Andrés Espinal Botero ; Gloria Isabel Mejía de Rodríguez
Título : Etiología y clínica de la ira baja adquirida en la comunidad en 100 niños estudiados a nivel hospitalario Tipo de documento : documento electrónico Autores : Hugo Trujillo Soto, ; Jaime Robledo, ; David Andrés Espinal Botero, ; Gloria Isabel Mejía de Rodríguez, Fecha de publicación : 1994 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Infección aguda de las vías respiratorias inferiores etiología niños entorno hospitalario Resumen : Se estudió la etiología de la infección respiratoria aguda inferior adquirida en la comunidad en cien niños hospitalizados, el 84% del grupo tenía 2 años o menos. En 48 de los casos se identificaron 56 microorganismos asociados, se identificó virus sincitial respiratorio en el 43,95% de los casos, seguido de S. pneumoniae 13,3%, H. Influenzae 12,9% (en un grupo seleccionado de casos), M. pneumoniae 3,22 %, B. pertussis 3,19%, virus Influenza A 1,04% y S. aureus 1%. Se documentaron infecciones mixtas en el 16,4% de los pacientes. Se relacionaron características clínicas y radiológicas con cada uno de los patógenos, se hacen recomendaciones terapéuticas incluyendo el uso de antibióticos. Mención de responsabilidad : Hugo Trujillo, Jaime Robledo, Francisco Javier Díaz, Jorge Mejía, David Espinal, Felipe Restrepo, Carlos Robledo, José Iván Ramírez, Carlos Restrepo, Gloria Isabel Mejía, Marta Claudia Tamayo Referencia : Med. U.P.B ; 13(1): 53-64, abr.1994. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/4963 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5018 Etiología y clínica de la ira baja adquirida en la comunidad en 100 niños estudiados a nivel hospitalario [documento electrónico] / Hugo Trujillo Soto, ; Jaime Robledo, ; David Andrés Espinal Botero, ; Gloria Isabel Mejía de Rodríguez, . - 1994.
Obra : Medicina U.P.B.
Idioma : Español (spa)
Palabras clave : Infección aguda de las vías respiratorias inferiores etiología niños entorno hospitalario Resumen : Se estudió la etiología de la infección respiratoria aguda inferior adquirida en la comunidad en cien niños hospitalizados, el 84% del grupo tenía 2 años o menos. En 48 de los casos se identificaron 56 microorganismos asociados, se identificó virus sincitial respiratorio en el 43,95% de los casos, seguido de S. pneumoniae 13,3%, H. Influenzae 12,9% (en un grupo seleccionado de casos), M. pneumoniae 3,22 %, B. pertussis 3,19%, virus Influenza A 1,04% y S. aureus 1%. Se documentaron infecciones mixtas en el 16,4% de los pacientes. Se relacionaron características clínicas y radiológicas con cada uno de los patógenos, se hacen recomendaciones terapéuticas incluyendo el uso de antibióticos. Mención de responsabilidad : Hugo Trujillo, Jaime Robledo, Francisco Javier Díaz, Jorge Mejía, David Espinal, Felipe Restrepo, Carlos Robledo, José Iván Ramírez, Carlos Restrepo, Gloria Isabel Mejía, Marta Claudia Tamayo Referencia : Med. U.P.B ; 13(1): 53-64, abr.1994. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/4963 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5018 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001578 AC-1994-008 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1994-008.pdfAdobe Acrobat PDF Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation / Fabio Uribe Jaramillo ; Ángela Inés Zuluaga Cadena ; Ángela Restrepo Moreno
Título : Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation Tipo de documento : documento electrónico Autores : Fabio Uribe Jaramillo, ; Ángela Inés Zuluaga Cadena, ; Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Balb/c mice were infected intradermally (ID) or subcutaneously (SC) with Sporothrix schenckii conidia, in an attempt to demonstrate the role played by the depth of inoculation on the course of the infectious process. Animals were observed weekly up to 6 weeks and the time of appearance, as well as the aspect of the lesions, was recorded. Thirty percent of the animals were autopsied and their organs subjected to histopathological study. All animals, irrespective of the route of inoculation, developed clinically detectable sporotrichosis; the resulting lesions (nodules, drained or undrained abscesses, pustules) tended towards spontaneous healing; most of the ID-inoculated mice healed after 3 weeks post-infection while the SC group took longer (5 weeks). Histologically, all the animals that were killed had inflammatory foci, but a larger proportion (57%) of those infected SC exhibited granuloma formation in comparison with the animals infected by the ID route (16·6%). During the first week post-inoculation, the enlargement of the inguinal lymph node did not coincide with the presence of histologically detectable hypertrophy; however, after 2 weeks, 70–80% of all animals had both types of abnormality. Our results indicate that irrespective of the route of inoculation all the mice developed clinically and histologically detectable sporotrichosis, albeit of a limited character. Mención de responsabilidad : S. Restrepo-Gutierrez, M. Arango-Arteaga, F. Uribe-Jaramillo, A.I. Zuluaga-Cadena, A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000541 En línea : https://academic.oup.com/mmy/article-abstract/31/6/411/988315 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4371 Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation [documento electrónico] / Fabio Uribe Jaramillo, ; Ángela Inés Zuluaga Cadena, ; Ángela Restrepo Moreno, . - 1993.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : Balb/c mice were infected intradermally (ID) or subcutaneously (SC) with Sporothrix schenckii conidia, in an attempt to demonstrate the role played by the depth of inoculation on the course of the infectious process. Animals were observed weekly up to 6 weeks and the time of appearance, as well as the aspect of the lesions, was recorded. Thirty percent of the animals were autopsied and their organs subjected to histopathological study. All animals, irrespective of the route of inoculation, developed clinically detectable sporotrichosis; the resulting lesions (nodules, drained or undrained abscesses, pustules) tended towards spontaneous healing; most of the ID-inoculated mice healed after 3 weeks post-infection while the SC group took longer (5 weeks). Histologically, all the animals that were killed had inflammatory foci, but a larger proportion (57%) of those infected SC exhibited granuloma formation in comparison with the animals infected by the ID route (16·6%). During the first week post-inoculation, the enlargement of the inguinal lymph node did not coincide with the presence of histologically detectable hypertrophy; however, after 2 weeks, 70–80% of all animals had both types of abnormality. Our results indicate that irrespective of the route of inoculation all the mice developed clinically and histologically detectable sporotrichosis, albeit of a limited character. Mención de responsabilidad : S. Restrepo-Gutierrez, M. Arango-Arteaga, F. Uribe-Jaramillo, A.I. Zuluaga-Cadena, A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000541 En línea : https://academic.oup.com/mmy/article-abstract/31/6/411/988315 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4371 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000871 AC-1993-005 Archivo digital Producción Científica Artículos científicos Disponible Gastrospirillum hominis in a child with chronic gastritis / Hugo Trujillo Soto ; David Andrés Espinal Botero
Título : Gastrospirillum hominis in a child with chronic gastritis Tipo de documento : documento electrónico Autores : Hugo Trujillo Soto, ; David Andrés Espinal Botero, Fecha de publicación : 1993 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Mención de responsabilidad : López Jaime A. M.D.; Tamayo, Marta C. M.T.; Mejía, Gloria I. M.T.; Trujillo, Hugo M.D.; Espinal, David M.D.; Pérez, Maria A. M.D.; Robledo, Jaime A. M.D. Referencia : Pediatr Infect Dis J. 1993 Aug;12(8):701-2. DOI (Digital Object Identifier) : 10.1097/00006454-199308000-00019 PMID : 8414788 En línea : https://journals.lww.com/pidj/Citation/1993/08000/GASTROSPIRILLUM_HOMINIS_IN_A_C [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4372 Gastrospirillum hominis in a child with chronic gastritis [documento electrónico] / Hugo Trujillo Soto, ; David Andrés Espinal Botero, . - 1993.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Mención de responsabilidad : López Jaime A. M.D.; Tamayo, Marta C. M.T.; Mejía, Gloria I. M.T.; Trujillo, Hugo M.D.; Espinal, David M.D.; Pérez, Maria A. M.D.; Robledo, Jaime A. M.D. Referencia : Pediatr Infect Dis J. 1993 Aug;12(8):701-2. DOI (Digital Object Identifier) : 10.1097/00006454-199308000-00019 PMID : 8414788 En línea : https://journals.lww.com/pidj/Citation/1993/08000/GASTROSPIRILLUM_HOMINIS_IN_A_C [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4372 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000872 AC-1993-006 Archivo digital Producción Científica Artículos científicos Disponible Factors associated with Paracoccidiodes brasiliensis infection among permanent residents of three endemic areas in Colombia / Diego Cadavid ; Ángela Restrepo Moreno
Título : Factors associated with Paracoccidiodes brasiliensis infection among permanent residents of three endemic areas in Colombia Tipo de documento : documento electrónico Autores : Diego Cadavid, ; Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Epidemiology and Infection Idioma : Inglés (eng) Resumen : The natural habitat of Paracoccidioides brasiliensis, the aetiologic agent of paracoccidioidomycosis, has not been determined. Consequently, the events leading to the acquisition of infection remain controversial. To identify factors associated with infection in endemic areas we conducted a survey in three rural communities in Colombia where we had previously diagnosed paracoccidioidomycosis in children. Permanent residents were surveyed taking into consideration environmental and occupational variables. Skin tests were used to classify subjects as infected or non-infected. Variables found associated with infection were: (i) community A: previous residence around Porce river and agriculture in vegetable gardens; (ii) community C: frequent use of specific water sources; (iii) community V: housekeeping activities, and (iv) total group: age > 25 years and contact with bats. Residents in communities with higher prevalence of infection were older, had more complex residence history, and referred more contact with armadillos than residents of communities with lower infection. Mención de responsabilidad : D. Cadavid and A. Restrepo Referencia : Epidemiol Infect. 1993 Aug;111(1):121-33. DOI (Digital Object Identifier) : 10.1017/s0950268800056740 PMID : 8348926 En línea : https://www.cambridge.org/core/journals/epidemiology-and-infection/article/facto [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4368 Factors associated with Paracoccidiodes brasiliensis infection among permanent residents of three endemic areas in Colombia [documento electrónico] / Diego Cadavid, ; Ángela Restrepo Moreno, . - 1993.
Obra : Epidemiology and Infection
Idioma : Inglés (eng)
Resumen : The natural habitat of Paracoccidioides brasiliensis, the aetiologic agent of paracoccidioidomycosis, has not been determined. Consequently, the events leading to the acquisition of infection remain controversial. To identify factors associated with infection in endemic areas we conducted a survey in three rural communities in Colombia where we had previously diagnosed paracoccidioidomycosis in children. Permanent residents were surveyed taking into consideration environmental and occupational variables. Skin tests were used to classify subjects as infected or non-infected. Variables found associated with infection were: (i) community A: previous residence around Porce river and agriculture in vegetable gardens; (ii) community C: frequent use of specific water sources; (iii) community V: housekeeping activities, and (iv) total group: age > 25 years and contact with bats. Residents in communities with higher prevalence of infection were older, had more complex residence history, and referred more contact with armadillos than residents of communities with lower infection. Mención de responsabilidad : D. Cadavid and A. Restrepo Referencia : Epidemiol Infect. 1993 Aug;111(1):121-33. DOI (Digital Object Identifier) : 10.1017/s0950268800056740 PMID : 8348926 En línea : https://www.cambridge.org/core/journals/epidemiology-and-infection/article/facto [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4368 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000868 AC-1993-001 Archivo digital Producción Científica Artículos científicos Disponible
Título : Claritromicina en amigdalofaringitis aguda estreptococcica Tipo de documento : documento electrónico Autores : Hugo Trujillo Soto, Fecha de publicación : 1993 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Streptococcus pyogenes amigdalitis aguda faringitis aguda claritromicina Resumen : Cuarenta pacientes de 10 años de edad o mayores con faringotonsilitis aguda por estreptococo del grupo A fueron tratados con el nuevo macrólido Claritromicina 250 mg dos veces al día durante 10 días. La concentración mínima inhibitoria de claritromicina varió de 0,06 mcg / ml a 0,5 mcg / ml. La tasa de curación clínica fue del 97%; 3% presentó mejoría. La tasa de curación bacteriológica fue del 92,5%. Se observaron reacciones adversas leves en 6 pacientes. En conclusión, la claritromicina es un fármaco eficaz y bien tolerado para la faringotonsllitis estreptocócica del grupo A. Mención de responsabilidad : Hugo Trujillo, Jaime A. Robledo, María A. Pérez, Rogelio Londoño, María P. Posada, Gloria I. Mejía, Marta C. Tamayo, Jaime A. López Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5162 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5055 Claritromicina en amigdalofaringitis aguda estreptococcica [documento electrónico] / Hugo Trujillo Soto, . - 1993.
Obra : Medicina U.P.B.
Idioma : Español (spa)
Palabras clave : Streptococcus pyogenes amigdalitis aguda faringitis aguda claritromicina Resumen : Cuarenta pacientes de 10 años de edad o mayores con faringotonsilitis aguda por estreptococo del grupo A fueron tratados con el nuevo macrólido Claritromicina 250 mg dos veces al día durante 10 días. La concentración mínima inhibitoria de claritromicina varió de 0,06 mcg / ml a 0,5 mcg / ml. La tasa de curación clínica fue del 97%; 3% presentó mejoría. La tasa de curación bacteriológica fue del 92,5%. Se observaron reacciones adversas leves en 6 pacientes. En conclusión, la claritromicina es un fármaco eficaz y bien tolerado para la faringotonsllitis estreptocócica del grupo A. Mención de responsabilidad : Hugo Trujillo, Jaime A. Robledo, María A. Pérez, Rogelio Londoño, María P. Posada, Gloria I. Mejía, Marta C. Tamayo, Jaime A. López Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5162 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5055 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001617 AC-1993-008 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1993-008.pdfAdobe Acrobat PDF
Título : Paracoccidioidomycosis: An update Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Clinical Microbiology Reviews Idioma : Inglés (eng) Resumen : This review summarizes knowledge on various aspects of paracoccidioidomycosis. Mycelial propagules, chlamydospores, and arthroconidia exhibit thermal dimorphism; arthroconidia are infectious in animals and, by electron microscopy, appear well provided for survival. The mycelial-to-yeast-phase transformation requires a strict control of glucan synthesis probably mediated by membrane enzymes. Hormonal influences on the transformation of the fungus (mycelium or conidium to yeast phase) have been demonstrated. Estrogen-binding proteins have been detected in the fungal cytosol, and during the transformation novel proteins are produced as a result of estradiol incorporation. Clinical forms have been better defined on the basis of better experimental models. Emphasis has been placed on the lungs as the portal of entry and on the existence of silent pulmonary infections. A specific Paracoccidioides brasiliensis antigen, the 43-kDa glycoprotein (Gp43), has been identified, characterized, and cloned. This has led to improved reproducibility and specificity of serologic tests. The depression of cell-mediated immune responses has been associated with severe disease in humans and in the experimental host. T-cell subsets in patients' tissues were characterized by means of monoclonal antibodies, and a reduced CD4/CD8 ratio was demonstrated. This has been related to alterations in lymphokine and tumor necrosis factor production, production of antigen-antibody complexes, etc. Amphotericin B has provided effective therapy. Azole derivatives have also improved prognosis and facilitated therapy. Itraconazole is presently the drug of choice, yet incapacitating sequelae (mainly pulmonary fibrosis) still constitute major problems. Mención de responsabilidad : E Brummer, E Castaneda, A Restrepo Referencia : Clin Microbiol Rev. 1993 Apr;6(2):89-117. DOI (Digital Object Identifier) : 10.1128/CMR.6.2.89 PMID : 8472249 En línea : https://cmr.asm.org/content/6/2/89 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4373 Paracoccidioidomycosis: An update [documento electrónico] / Ángela Restrepo Moreno, . - 1993.
Obra : Clinical Microbiology Reviews
Idioma : Inglés (eng)
Resumen : This review summarizes knowledge on various aspects of paracoccidioidomycosis. Mycelial propagules, chlamydospores, and arthroconidia exhibit thermal dimorphism; arthroconidia are infectious in animals and, by electron microscopy, appear well provided for survival. The mycelial-to-yeast-phase transformation requires a strict control of glucan synthesis probably mediated by membrane enzymes. Hormonal influences on the transformation of the fungus (mycelium or conidium to yeast phase) have been demonstrated. Estrogen-binding proteins have been detected in the fungal cytosol, and during the transformation novel proteins are produced as a result of estradiol incorporation. Clinical forms have been better defined on the basis of better experimental models. Emphasis has been placed on the lungs as the portal of entry and on the existence of silent pulmonary infections. A specific Paracoccidioides brasiliensis antigen, the 43-kDa glycoprotein (Gp43), has been identified, characterized, and cloned. This has led to improved reproducibility and specificity of serologic tests. The depression of cell-mediated immune responses has been associated with severe disease in humans and in the experimental host. T-cell subsets in patients' tissues were characterized by means of monoclonal antibodies, and a reduced CD4/CD8 ratio was demonstrated. This has been related to alterations in lymphokine and tumor necrosis factor production, production of antigen-antibody complexes, etc. Amphotericin B has provided effective therapy. Azole derivatives have also improved prognosis and facilitated therapy. Itraconazole is presently the drug of choice, yet incapacitating sequelae (mainly pulmonary fibrosis) still constitute major problems. Mención de responsabilidad : E Brummer, E Castaneda, A Restrepo Referencia : Clin Microbiol Rev. 1993 Apr;6(2):89-117. DOI (Digital Object Identifier) : 10.1128/CMR.6.2.89 PMID : 8472249 En línea : https://cmr.asm.org/content/6/2/89 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4373 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000873 AC-1993-007 Archivo digital Producción Científica Artículos científicos Disponible Disseminated adiaspiromycosis in a patient with AIDS / Luz Elena Cano Restrepo ; Ángela Restrepo Moreno
Título : Disseminated adiaspiromycosis in a patient with AIDS Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : A case of disseminated adiaspiromycosis in an AIDS patient is described. The most notable characteristic of the infection was the extensive osteomyelitis exhibited by the patient. Positive cultures for Chrysosporium parvum var. parvum were obtained from pus taken from a lesion of the wrist during surgery as well as from sputum samples and a bone marrow aspirate. Treatment with amphotericin B controlled the fungal infection. Mención de responsabilidad : E. Echavarria, E.L. Cano, A. Restrepo Referencia : J Med Vet Mycol. 1993;31(1):91-7. DOI (Digital Object Identifier) : 10.1080/02681219380000101 PMID : 8483061 En línea : https://academic.oup.com/mmy/article-abstract/31/1/91/942394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4369 Disseminated adiaspiromycosis in a patient with AIDS [documento electrónico] / Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, . - 1993.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : A case of disseminated adiaspiromycosis in an AIDS patient is described. The most notable characteristic of the infection was the extensive osteomyelitis exhibited by the patient. Positive cultures for Chrysosporium parvum var. parvum were obtained from pus taken from a lesion of the wrist during surgery as well as from sputum samples and a bone marrow aspirate. Treatment with amphotericin B controlled the fungal infection. Mención de responsabilidad : E. Echavarria, E.L. Cano, A. Restrepo Referencia : J Med Vet Mycol. 1993;31(1):91-7. DOI (Digital Object Identifier) : 10.1080/02681219380000101 PMID : 8483061 En línea : https://academic.oup.com/mmy/article-abstract/31/1/91/942394 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4369 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000869 AC-1993-002 Archivo digital Producción Científica Artículos científicos Disponible Detection of proteolytic enzymes released by the dimorphic fungus Paracoccidioides brasiliensis / Victoria Inés Bedoya Escobar ; María Soledad Naranjo Mesa ; Ángela Restrepo Moreno
Título : Detection of proteolytic enzymes released by the dimorphic fungus Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Victoria Inés Bedoya Escobar, ; María Soledad Naranjo Mesa, ; Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The release of proteolytic enzymes with elastinolytic and collagenolytic activity was investigated in 10 different isolates of Paracoccidioides brasiliensis. The study encompassed both the mycelial and the yeast phase of the fungus. In the mycelial phase, secretion of elastinolytic and collagenolytic enzymes was demonstrated in 70% and 80% of the isolates, respectively. None of the isolates in the yeast phase exhibited elastinolytic activity, but 90% showed collagenolytic activity. These results demonstrate that the dimorphic fungus P. brasiliensis has the ability to release proteolytic enzymes in both growth phases, although with apparently different specificities. Mención de responsabilidad : V.I. Bedoya-Escobar, M.S. Naranjo-Mesa & A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000361 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219380000361 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4370 Detection of proteolytic enzymes released by the dimorphic fungus Paracoccidioides brasiliensis [documento electrónico] / Victoria Inés Bedoya Escobar, ; María Soledad Naranjo Mesa, ; Ángela Restrepo Moreno, . - 1993.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : The release of proteolytic enzymes with elastinolytic and collagenolytic activity was investigated in 10 different isolates of Paracoccidioides brasiliensis. The study encompassed both the mycelial and the yeast phase of the fungus. In the mycelial phase, secretion of elastinolytic and collagenolytic enzymes was demonstrated in 70% and 80% of the isolates, respectively. None of the isolates in the yeast phase exhibited elastinolytic activity, but 90% showed collagenolytic activity. These results demonstrate that the dimorphic fungus P. brasiliensis has the ability to release proteolytic enzymes in both growth phases, although with apparently different specificities. Mención de responsabilidad : V.I. Bedoya-Escobar, M.S. Naranjo-Mesa & A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000361 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219380000361 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4370 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000870 AC-1993-004 Archivo digital Producción Científica Artículos científicos Disponible Development of pulmonary fibrosis in mice during infection with Paracoccidioides brasiliensis conidia / Susana Restrepo ; Ángela María Tobón Orozco ; Ángela Restrepo Moreno
Título : Development of pulmonary fibrosis in mice during infection with Paracoccidioides brasiliensis conidia Tipo de documento : documento electrónico Autores : Susana Restrepo, ; Ángela María Tobón Orozco, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Pulmonary fibrosis is a feared sequelae of paracoccidioidomycosis. We sought to determine if mice exposed to Paracoccidioides brasiliensis conidia would develop pulmonary fibrosis. BALB/c mice were infected intranasally with P. brasiliensis conidia and sacrificed at regular intervals. One lung was sectioned for histopathology and sections were stained with haematoxylin and eosin, trichromic and argentic stains; the other lung was homogenized and cultured to determine the viability of the fungus. One week post-challenge, only small peribronchial foci were apparent. After 4 weeks, reticular fibres appeared disorganized and disrupted. Six to 8 weeks later peribronchial infiltrates were larger and appeared surrounded by reticular fibres; thick collagen I fibres were noticed in the infiltrated areas at this time. On weeks 10–12, infiltrates were confluent and reticular fibres were concentrated around the inflammatory foci; collagenization was apparent. Observations up to 16 weeks revealed diffuse involvement of the lung parenchyma with extensive collagenization. Lung cultures were always positive. We suggest that inhalation of P. brasiliensis conidia induces adverse lung responses leading to changes in the proportion of collagen fibres I and III. Mención de responsabilidad : S. Restrepo, A. Tobon, J. Trujillo & A. Restrepo Referencia : J Med Vet Mycol. 1992;30(3):173-84. PMID : 1517956 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219280000241 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4366 Development of pulmonary fibrosis in mice during infection with Paracoccidioides brasiliensis conidia [documento electrónico] / Susana Restrepo, ; Ángela María Tobón Orozco, ; Ángela Restrepo Moreno, . - 1992.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : Pulmonary fibrosis is a feared sequelae of paracoccidioidomycosis. We sought to determine if mice exposed to Paracoccidioides brasiliensis conidia would develop pulmonary fibrosis. BALB/c mice were infected intranasally with P. brasiliensis conidia and sacrificed at regular intervals. One lung was sectioned for histopathology and sections were stained with haematoxylin and eosin, trichromic and argentic stains; the other lung was homogenized and cultured to determine the viability of the fungus. One week post-challenge, only small peribronchial foci were apparent. After 4 weeks, reticular fibres appeared disorganized and disrupted. Six to 8 weeks later peribronchial infiltrates were larger and appeared surrounded by reticular fibres; thick collagen I fibres were noticed in the infiltrated areas at this time. On weeks 10–12, infiltrates were confluent and reticular fibres were concentrated around the inflammatory foci; collagenization was apparent. Observations up to 16 weeks revealed diffuse involvement of the lung parenchyma with extensive collagenization. Lung cultures were always positive. We suggest that inhalation of P. brasiliensis conidia induces adverse lung responses leading to changes in the proportion of collagen fibres I and III. Mención de responsabilidad : S. Restrepo, A. Tobon, J. Trujillo & A. Restrepo Referencia : J Med Vet Mycol. 1992;30(3):173-84. PMID : 1517956 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219280000241 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4366 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000866 AC-1992-005 Archivo digital Producción Científica Artículos científicos Disponible El caso de infecciosas. Tuberculosis miliar y síndrome de dificultad respiratoria del adulto / Alejandro Londoño Villegas
Título : El caso de infecciosas. Tuberculosis miliar y síndrome de dificultad respiratoria del adulto Tipo de documento : documento electrónico Autores : Alejandro Londoño Villegas, Fecha de publicación : 1992 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : TBC miliar Síndrome de dificultad respiratoria del adulto Barotrauma Mycobacterium tuberculosis Ventilación mecánica controlada Estreptomicina isoniazida Pirazinamida Rifampicina Resumen : Presentamos el caso de una paciente de 19 años que; durante el embarazo, desarrolló una tuberculosis miliar (TB) y un síndrome de dificultad respiratoria del adulto (AROS). La biopsia hepática reveló granulomas caseosos y células de Longhand. Los pacientes requirieron CMV con PEEP. Recibió tratamiento para la tuberculosis con SM, INH, RMP y PZ. También recibió esteroides sistémicos. Los pacientes se recuperaron insatisfactoriamente presentando barotraumatismo bilateral, fístulas broncopleurales y finalmente muere. Se hace una revisión de las pocas publicaciones sobre la asociación de la TB miliar y el SDRA. Mención de responsabilidad : Carlos Alejandro Botero G., Alejandro Londoño V. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5220 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5053 El caso de infecciosas. Tuberculosis miliar y síndrome de dificultad respiratoria del adulto [documento electrónico] / Alejandro Londoño Villegas, . - 1992.
Obra : Medicina U.P.B.
Idioma : Español (spa)
Palabras clave : TBC miliar Síndrome de dificultad respiratoria del adulto Barotrauma Mycobacterium tuberculosis Ventilación mecánica controlada Estreptomicina isoniazida Pirazinamida Rifampicina Resumen : Presentamos el caso de una paciente de 19 años que; durante el embarazo, desarrolló una tuberculosis miliar (TB) y un síndrome de dificultad respiratoria del adulto (AROS). La biopsia hepática reveló granulomas caseosos y células de Longhand. Los pacientes requirieron CMV con PEEP. Recibió tratamiento para la tuberculosis con SM, INH, RMP y PZ. También recibió esteroides sistémicos. Los pacientes se recuperaron insatisfactoriamente presentando barotraumatismo bilateral, fístulas broncopleurales y finalmente muere. Se hace una revisión de las pocas publicaciones sobre la asociación de la TB miliar y el SDRA. Mención de responsabilidad : Carlos Alejandro Botero G., Alejandro Londoño V. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5220 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5053 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001615 AC-1992-008 Archivo digital Producción Científica Artículos científicos Disponible Saperconazole in the treatment of systemic and subcutaneous mycoses / Liliana Franco R. ; Iván Gómez ; Ángela Restrepo Moreno
Título : Saperconazole in the treatment of systemic and subcutaneous mycoses Tipo de documento : documento electrónico Autores : Liliana Franco R., ; Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : International Journal of Dermatology Idioma : Inglés (eng) Resumen : In a 2‐year period, 30 patients with culture‐proven mycoses (chromoblastomycosis, sporotrichosis, and paracoccid‐ioidomycosis) were treated with the new orally administered triazole, saperconazole (SPZ) (R66905). The daily dose varied from 100 to 200 mg. All patients responded to treatment; the mean time required to heal the lesions and convert the cultures to negative was 3.5 months for sporotrichosis, 4.6 for paracoccidioidomycosis, and 9.0 for chromoblastomycosis. Evaluation by a scoring system indicated that 36.6% of the patients achieved complete resolution of the pretherapy abnormalities, while the remaining (63.3%) experienced major improvement. No colateral effects were reported; there were no bone‐marrow or liver toxicities. SPZ is an effective drug for the treatment of the above‐mentioned mycoses and appears to be suitable for the control of chromoblastomycosis. Mención de responsabilidad : Liliana Franco M.D. Ivan Gomez M.D. Angela Restrepo Ph.D. Referencia : Int J Dermatol. 1992 Oct;31(10):725-9. DOI (Digital Object Identifier) : 10.1111/j.1365-4362.1992.tb01384.x PMID : 1399205 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4362.1992.tb01384.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4362 Saperconazole in the treatment of systemic and subcutaneous mycoses [documento electrónico] / Liliana Franco R., ; Iván Gómez, ; Ángela Restrepo Moreno, . - 1992.
Obra : International Journal of Dermatology
Idioma : Inglés (eng)
Resumen : In a 2‐year period, 30 patients with culture‐proven mycoses (chromoblastomycosis, sporotrichosis, and paracoccid‐ioidomycosis) were treated with the new orally administered triazole, saperconazole (SPZ) (R66905). The daily dose varied from 100 to 200 mg. All patients responded to treatment; the mean time required to heal the lesions and convert the cultures to negative was 3.5 months for sporotrichosis, 4.6 for paracoccidioidomycosis, and 9.0 for chromoblastomycosis. Evaluation by a scoring system indicated that 36.6% of the patients achieved complete resolution of the pretherapy abnormalities, while the remaining (63.3%) experienced major improvement. No colateral effects were reported; there were no bone‐marrow or liver toxicities. SPZ is an effective drug for the treatment of the above‐mentioned mycoses and appears to be suitable for the control of chromoblastomycosis. Mención de responsabilidad : Liliana Franco M.D. Ivan Gomez M.D. Angela Restrepo Ph.D. Referencia : Int J Dermatol. 1992 Oct;31(10):725-9. DOI (Digital Object Identifier) : 10.1111/j.1365-4362.1992.tb01384.x PMID : 1399205 En línea : https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4362.1992.tb01384.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4362 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000862 AC-1992-001 Archivo digital Producción Científica Artículos científicos Disponible A pan-american 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host / Ángela Restrepo Moreno
Título : A pan-american 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Clinical Infectious Diseases Idioma : Inglés (eng) Resumen : Eighty-eight immunocompetent patients with deep mycoses from eight countries were evaluated with the same protocol for efficacy of fluconazole monotherapy. Entry doses were raised from 100 to 400 mg as safety was shown in initial cohorts, and dosages up to 2,400 mg daily and durations up to 44 months were studied. Results were very similar in different countries. Twenty-seven of 28 evaluable patients with paracoccidioidomycosis, 13 of 19 with sporotrichosis, 14 of 16 with coccidioidomycosis, and eight of eight with histoplasmosis demonstrated objective responses to therapy, as did one patient each with zygomycosis and alternariosis. For these patients, relapses have been unusual thus far. In contrast, one patient with chromoblastomycosis responded but relapsed, and six did not respond; one patient with mycetoma responded but relapsed, and two did not respond. The drug was well tolerated by patients, including six who received intravenous therapy. In vitro susceptibility tests suggested that clinical response was correlated with susceptibility but that resistance did not preclude clinical response. Fluconazole therapy appears efficacious for several deep mycoses; dosages of >200 mg daily may be needed for some diseases. The further evaluation of fluconazole for these entities is warranted. Mención de responsabilidad : Manuel Diaz, Ricardo Negroni, Fernando Montero-Gei, Luiz G. M. Castro, Sebastiao A. P. Sampaio, Dante Borelli, Angela Restrepo, Liliana Franco, Jose L. Bran, Eduardo G. Arathoon, David A. Stevens other investigators of the Fluconazole Pan-American Study Group Referencia : Clin Infect Dis. 1992 Mar;14 Suppl 1:S68-76. DOI (Digital Object Identifier) : 10.1093/clinids/14.Supplement_1.S68 PMID : 1562698 En línea : https://academic.oup.com/cid/article-abstract/14/Supplement_1/S68/366004 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4367 A pan-american 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host [documento electrónico] / Ángela Restrepo Moreno, . - 1992.
Obra : Clinical Infectious Diseases
Idioma : Inglés (eng)
Resumen : Eighty-eight immunocompetent patients with deep mycoses from eight countries were evaluated with the same protocol for efficacy of fluconazole monotherapy. Entry doses were raised from 100 to 400 mg as safety was shown in initial cohorts, and dosages up to 2,400 mg daily and durations up to 44 months were studied. Results were very similar in different countries. Twenty-seven of 28 evaluable patients with paracoccidioidomycosis, 13 of 19 with sporotrichosis, 14 of 16 with coccidioidomycosis, and eight of eight with histoplasmosis demonstrated objective responses to therapy, as did one patient each with zygomycosis and alternariosis. For these patients, relapses have been unusual thus far. In contrast, one patient with chromoblastomycosis responded but relapsed, and six did not respond; one patient with mycetoma responded but relapsed, and two did not respond. The drug was well tolerated by patients, including six who received intravenous therapy. In vitro susceptibility tests suggested that clinical response was correlated with susceptibility but that resistance did not preclude clinical response. Fluconazole therapy appears efficacious for several deep mycoses; dosages of >200 mg daily may be needed for some diseases. The further evaluation of fluconazole for these entities is warranted. Mención de responsabilidad : Manuel Diaz, Ricardo Negroni, Fernando Montero-Gei, Luiz G. M. Castro, Sebastiao A. P. Sampaio, Dante Borelli, Angela Restrepo, Liliana Franco, Jose L. Bran, Eduardo G. Arathoon, David A. Stevens other investigators of the Fluconazole Pan-American Study Group Referencia : Clin Infect Dis. 1992 Mar;14 Suppl 1:S68-76. DOI (Digital Object Identifier) : 10.1093/clinids/14.Supplement_1.S68 PMID : 1562698 En línea : https://academic.oup.com/cid/article-abstract/14/Supplement_1/S68/366004 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4367 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000867 AC-1992-006 Archivo digital Producción Científica Artículos científicos Disponible Perfil de seguridad del itraconazol / María Teresa Ochoa ; María Adelaida Botero ; Liliana Franco R. ; Iván Gómez ; Ángela Restrepo Moreno
Título : Perfil de seguridad del itraconazol Tipo de documento : documento electrónico Autores : María Teresa Ochoa, ; María Adelaida Botero, ; Liliana Franco R., ; Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Itraconazol Toxicidad Micosis Resumen : Durante el período 1984-1989, 110 pacientes con micosis sistémicas y subcutáneas fueron tratados con un nuevo derivado de imidazol (ltraconazol, ITZ); 44 pacientes tenían paracoccidioidomicosis, 34 esporotricosis, 18 cromoblastomicosis y 14 aspergiloma pulmonar. Según la gravedad de la enfermedad, se administró ITZ en dosis de 100 mg / día (89 casos) o de 200 mg / día (21 casos). La duración media de la terapia fue de 18 meses en ASP, 13 en CMB, 7 en PCM y 5 en SPT. La ITZ fue bien tolerada y solo el 6,3% de los pacientes se quejaron de intolerancia gástrica leve. Las pruebas de función hematológica y hepática se mantuvieron dentro de los límites de la normalidad en todos los pacientes, incluso aquellos que presentaron disfunción hepática antes de la cirugía, mejoraron durante el tratamiento con ITZ. Mención de responsabilidad : María Teresa Ochoa, María Adelaida Botero, Liliana Franco, Iván Gómez, Ángela Restrepo M. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5223 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5054 Perfil de seguridad del itraconazol [documento electrónico] / María Teresa Ochoa, ; María Adelaida Botero, ; Liliana Franco R., ; Iván Gómez, ; Ángela Restrepo Moreno, . - 1992.
Obra : Medicina U.P.B.
Idioma : Español (spa)
Palabras clave : Itraconazol Toxicidad Micosis Resumen : Durante el período 1984-1989, 110 pacientes con micosis sistémicas y subcutáneas fueron tratados con un nuevo derivado de imidazol (ltraconazol, ITZ); 44 pacientes tenían paracoccidioidomicosis, 34 esporotricosis, 18 cromoblastomicosis y 14 aspergiloma pulmonar. Según la gravedad de la enfermedad, se administró ITZ en dosis de 100 mg / día (89 casos) o de 200 mg / día (21 casos). La duración media de la terapia fue de 18 meses en ASP, 13 en CMB, 7 en PCM y 5 en SPT. La ITZ fue bien tolerada y solo el 6,3% de los pacientes se quejaron de intolerancia gástrica leve. Las pruebas de función hematológica y hepática se mantuvieron dentro de los límites de la normalidad en todos los pacientes, incluso aquellos que presentaron disfunción hepática antes de la cirugía, mejoraron durante el tratamiento con ITZ. Mención de responsabilidad : María Teresa Ochoa, María Adelaida Botero, Liliana Franco, Iván Gómez, Ángela Restrepo M. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5223 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5054 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001616 AC-1992-009 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1992-009.pdfAdobe Acrobat PDF Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages / Luz Elena Cano Restrepo ; Ángela Restrepo Moreno
Título : Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice significantly inhibited transformation of ingested conidia. Mención de responsabilidad : L E Cano, E Brummer, D A Stevens, A Restrepo Referencia : Infect Immun. 1992 May;60(5):2096-100. PMID : 1563800 En línea : https://iai.asm.org/content/60/5/2096.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4363 Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages [documento electrónico] / Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, . - 1992.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice significantly inhibited transformation of ingested conidia. Mención de responsabilidad : L E Cano, E Brummer, D A Stevens, A Restrepo Referencia : Infect Immun. 1992 May;60(5):2096-100. PMID : 1563800 En línea : https://iai.asm.org/content/60/5/2096.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4363 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000863 AC-1992-002 Archivo digital Producción Científica Artículos científicos Disponible Activity of two different triazoles in a murine model of paracoccidioidomycosis / Susana Restrepo ; Ángela María Tabares Velásquez ; Ángela Restrepo Moreno
Título : Activity of two different triazoles in a murine model of paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Activity of two different triazoles in a murine model of paracoccidioidomycosis [documento electrónico] / Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, . - 1992.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000864 AC-1992-003 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1992-003.pdfAdobe Acrobat PDF