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Immunogenicity and safety of booster CYD-TDV dengue vaccine after alternative primary vaccination schedules in healthy individuals aged 9–50 years: a randomised, controlled, phase 2, non-inferiority study / Isabel Cristina Ramírez Sánchez
Título : Immunogenicity and safety of booster CYD-TDV dengue vaccine after alternative primary vaccination schedules in healthy individuals aged 9–50 years: a randomised, controlled, phase 2, non-inferiority study Tipo de documento : documento electrónico Autores : Isabel Cristina Ramírez Sánchez, Fecha de publicación : 2022 Títulos uniformes : The Lancet Infectious Diseases Idioma : Inglés (eng) Resumen : Background: Dengue is endemic in many countries throughout the tropics and subtropics, and the disease causes substantial morbidity and health-care burdens in these regions. We previously compared antibody responses after one-dose, two-dose, or three-dose primary regimens with the only approved dengue vaccine CYD-TDV (Dengvaxia; Sanofi Pasteur, Lyon, France) in individuals aged 9 years and older with previous dengue exposure. In this study, we assessed the need for a CYD-TDV booster after these primary vaccination regimens. Methods: In this randomised, controlled, phase 2, non-inferiority study, healthy individuals aged 9–50 years recruited from three sites in Colombia and three sites in the Philippines (excluding those with the usual contraindications to vaccinations) were randomly assigned 1:1:1 via a permuted block method with stratification by site and by age group using an independent voice response system to receive, at 6-month intervals, three doses of CYD-TDV (three-dose group), one dose of placebo followed by two doses of CYD-TDV (two-dose group), or two doses of placebo followed by one dose of CYD-TDV (one-dose group). Participants were also randomly assigned (1:1) to receive a CYD-TDV booster at 1 year or 2 years after the last primary dose. Each CYD-TDV dose was 0·5 mL and administered subcutaneously in the deltoid region of the upper arm. The investigators and sponsor, study staff interacting with the investigators, and participants and their parents or legally acceptable representatives were masked to group assignment. Neutralising antibodies were measured by 50% plaque reduction neutralisation testing, and geometric mean titres (GMTs) were calculated. Due to a change in study protocol, only participants who were dengue seropositive at baseline in the Colombian cohort received a booster vaccination. The primary outcome was to show non-inferiority of the booster dose administered at 1 year or 2 years after the two-dose and three-dose primary regimens; non-inferiority was shown if the lower limit of the two-sided adjusted 95% CI of the between-group (day 28 post-booster dose GMT from the three-dose or two-dose group vs day 28 GMT post-dose three of the three-dose primary regimen [three-dose group]) geometric mean ratio (GMR) was higher than 0·5 for each serotype. Non-inferiority of the 1-year or 2-year booster was shown if all four serotypes achieved non-inferiority. Safety was assessed among all participants who received the booster. This trial is registered with ClinicalTrials.gov, NCT02628444, and is closed to accrual. Findings: Between May 2 and Sept 16, 2016, we recruited and enrolled 1050 individuals who received either vaccine or placebo. Of the 350, 348, and 352 individuals randomly assigned to three-dose, two-dose, and one-dose groups, respectively, 108, 115, and 115 from the Colombian cohort were dengue seropositive at baseline and received a booster; 55 and 53 in the three-dose group received a booster after 1 year and 2 years, respectively, as did 59 and 56 in the two-dose group, and 62 and 53 in the one-dose group. After the three-dose primary schedule, non-inferiority was shown for serotypes 2 (GMR 0·746; 95% CI 0·550–1·010) and 3 (1·040; 0·686–1·570) but not serotypes 1 (0·567; 0·399–0·805) and 4 (0·647; 0·434–0·963) for the 1-year booster, and again for serotypes 2 (0·871; 0·673–1·130) and 3 (1·150; 0·887–1·490) but not serotypes 1 (0·688; 0·479–0·989) and 4 (0·655; 0·471–0·911) for the 2-year booster. Similarly, after the two-dose primary schedule, non-inferiority was shown for serotypes 2 (0·809; 0·505–1·300) and 3 (1·19; 0·732–1·940) but not serotypes 1 (0·627; 0·342–1·150) and 4 (0·499; 0·331–0·754) for the 1-year booster, and for serotype 3 (0·911; 0·573–1·450) but not serotypes 1 (0·889; 0·462–1·710), 2 (0·677; 0·402–1·140), and 4 (0·702; 0·447–1·100) for the 2-year booster. Thus, non-inferiority of the 1-year or 2-year booster was not shown after the three-dose or two-dose primary vaccination regimen in dengue-seropositive participants. No safety concerns occurred with the 1-year or 2-year CYD-TDV booster. Interpretation: CYD-TDV booster 1 year or 2 years after the two-dose or three-dose primary vaccination regimen does not elicit a consistent, meaningful booster effect against all dengue serotypes in participants who are seropositive for dengue at baseline. Mención de responsabilidad : Diana Leticia Coronel-Martinez, Juliana Park, Eduardo López-Medina, María Rosario Capeding, Andrés Angelo Cadena Bonfanti, María Cecilia Montalbán, Isabel Ramírez, María Liza Antoinette Gonzales, Betzana Zambrano, Gustavo Dayan, Zhenghong Chen, Hao Wang, Matthew Bonaparte, Andrey Rojas, Jenny Carolina Ramírez, Mae Ann Verdan, Fernando Noriega Referencia : Lancet Infect Dis. 2022 Jun;22(6):901-911. DOI (Digital Object Identifier) : 10.1016/S1473-3099(21)00706-4 PMID : 35364022 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1473309921007064 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6018 Immunogenicity and safety of booster CYD-TDV dengue vaccine after alternative primary vaccination schedules in healthy individuals aged 9–50 years: a randomised, controlled, phase 2, non-inferiority study [documento electrónico] / Isabel Cristina Ramírez Sánchez, . - 2022.
Obra : The Lancet Infectious Diseases
Idioma : Inglés (eng)
Resumen : Background: Dengue is endemic in many countries throughout the tropics and subtropics, and the disease causes substantial morbidity and health-care burdens in these regions. We previously compared antibody responses after one-dose, two-dose, or three-dose primary regimens with the only approved dengue vaccine CYD-TDV (Dengvaxia; Sanofi Pasteur, Lyon, France) in individuals aged 9 years and older with previous dengue exposure. In this study, we assessed the need for a CYD-TDV booster after these primary vaccination regimens. Methods: In this randomised, controlled, phase 2, non-inferiority study, healthy individuals aged 9–50 years recruited from three sites in Colombia and three sites in the Philippines (excluding those with the usual contraindications to vaccinations) were randomly assigned 1:1:1 via a permuted block method with stratification by site and by age group using an independent voice response system to receive, at 6-month intervals, three doses of CYD-TDV (three-dose group), one dose of placebo followed by two doses of CYD-TDV (two-dose group), or two doses of placebo followed by one dose of CYD-TDV (one-dose group). Participants were also randomly assigned (1:1) to receive a CYD-TDV booster at 1 year or 2 years after the last primary dose. Each CYD-TDV dose was 0·5 mL and administered subcutaneously in the deltoid region of the upper arm. The investigators and sponsor, study staff interacting with the investigators, and participants and their parents or legally acceptable representatives were masked to group assignment. Neutralising antibodies were measured by 50% plaque reduction neutralisation testing, and geometric mean titres (GMTs) were calculated. Due to a change in study protocol, only participants who were dengue seropositive at baseline in the Colombian cohort received a booster vaccination. The primary outcome was to show non-inferiority of the booster dose administered at 1 year or 2 years after the two-dose and three-dose primary regimens; non-inferiority was shown if the lower limit of the two-sided adjusted 95% CI of the between-group (day 28 post-booster dose GMT from the three-dose or two-dose group vs day 28 GMT post-dose three of the three-dose primary regimen [three-dose group]) geometric mean ratio (GMR) was higher than 0·5 for each serotype. Non-inferiority of the 1-year or 2-year booster was shown if all four serotypes achieved non-inferiority. Safety was assessed among all participants who received the booster. This trial is registered with ClinicalTrials.gov, NCT02628444, and is closed to accrual. Findings: Between May 2 and Sept 16, 2016, we recruited and enrolled 1050 individuals who received either vaccine or placebo. Of the 350, 348, and 352 individuals randomly assigned to three-dose, two-dose, and one-dose groups, respectively, 108, 115, and 115 from the Colombian cohort were dengue seropositive at baseline and received a booster; 55 and 53 in the three-dose group received a booster after 1 year and 2 years, respectively, as did 59 and 56 in the two-dose group, and 62 and 53 in the one-dose group. After the three-dose primary schedule, non-inferiority was shown for serotypes 2 (GMR 0·746; 95% CI 0·550–1·010) and 3 (1·040; 0·686–1·570) but not serotypes 1 (0·567; 0·399–0·805) and 4 (0·647; 0·434–0·963) for the 1-year booster, and again for serotypes 2 (0·871; 0·673–1·130) and 3 (1·150; 0·887–1·490) but not serotypes 1 (0·688; 0·479–0·989) and 4 (0·655; 0·471–0·911) for the 2-year booster. Similarly, after the two-dose primary schedule, non-inferiority was shown for serotypes 2 (0·809; 0·505–1·300) and 3 (1·19; 0·732–1·940) but not serotypes 1 (0·627; 0·342–1·150) and 4 (0·499; 0·331–0·754) for the 1-year booster, and for serotype 3 (0·911; 0·573–1·450) but not serotypes 1 (0·889; 0·462–1·710), 2 (0·677; 0·402–1·140), and 4 (0·702; 0·447–1·100) for the 2-year booster. Thus, non-inferiority of the 1-year or 2-year booster was not shown after the three-dose or two-dose primary vaccination regimen in dengue-seropositive participants. No safety concerns occurred with the 1-year or 2-year CYD-TDV booster. Interpretation: CYD-TDV booster 1 year or 2 years after the two-dose or three-dose primary vaccination regimen does not elicit a consistent, meaningful booster effect against all dengue serotypes in participants who are seropositive for dengue at baseline. Mención de responsabilidad : Diana Leticia Coronel-Martinez, Juliana Park, Eduardo López-Medina, María Rosario Capeding, Andrés Angelo Cadena Bonfanti, María Cecilia Montalbán, Isabel Ramírez, María Liza Antoinette Gonzales, Betzana Zambrano, Gustavo Dayan, Zhenghong Chen, Hao Wang, Matthew Bonaparte, Andrey Rojas, Jenny Carolina Ramírez, Mae Ann Verdan, Fernando Noriega Referencia : Lancet Infect Dis. 2022 Jun;22(6):901-911. DOI (Digital Object Identifier) : 10.1016/S1473-3099(21)00706-4 PMID : 35364022 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1473309921007064 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6018 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001856 AC-2022-024 Archivo digital Producción Científica Artículos científicos Disponible Risk factors for ophthalmologic involvement and ocular findings in patients diagnosed with fungemia in a high-complexity hospital in the city of Medellín, Colombia / Luis Fernando Velásquez Ossa ; Jorge Hernando Donado Gómez ; Laura Nataly Higuita Duque
Título : Risk factors for ophthalmologic involvement and ocular findings in patients diagnosed with fungemia in a high-complexity hospital in the city of Medellín, Colombia Tipo de documento : documento electrónico Autores : Luis Fernando Velásquez Ossa, ; Jorge Hernando Donado Gómez, ; Laura Nataly Higuita Duque, Fecha de publicación : 2022 Títulos uniformes : Annals of Medicine Idioma : Inglés (eng) Palabras clave : Fundus Oculi Fungemia candida retina Resumen : Purpose: To describe the demographic clinical characteristics and to identify the risk factors of patients diagnosed with fungemia and secondary intraocular involvement. Methods: Retrospective cohort of 97 patients diagnosed with fungemia and with or without involvement of the posterior segment. Demographic, clinical and ophthalmological variables were identified to establish the risk of retinal seeding. Results: An incidence of ocular involvement of 22.68% was obtained and no clear risk factor was found for subsequent showings in patients with fungemia. A risk trend was only found in patients with diabetes with an OR: 2.85; CI 95%: (0.80-10.12) and history of HIV with an OR: 2.29 CI95%: (0.85-6.12). Conclusions: In this first cohort carried out in Colombia according to our search, findings were obtained that agree with those of other authors worldwide, where there is no evidence of a decrease in incidence compared with older studies and the absence of risk factors for the compromise of the posterior pole in patients with fungemia.KEY MESSAGES Systematic fundus evaluation by an ophthalmologist in patients with candidaemia is a recommended practice based on low-quality evidence.The identification of real risk factors for retinal compromise in fungemia would allow us to be more selective with the population to be evaluated.Fungemia generally occurs in critically ill patients, where access and availability of ophthalmology evaluation are a resource that is not always available. Mención de responsabilidad : Marcos Restrepo Arango, Juan Camilo Cadavid Usuga, Luis Fernando Velazquez Ossa, Jorge Hernando Donado Gómez, Laura Nataly Higuita Duque, Juan Pedro Neira Gomez Referencia : Ann Med. 2022 Dec;54(1):2204-2210. DOI (Digital Object Identifier) : 10.1080/07853890.2022.2107700 Derechos de uso : CC BY En línea : https://www.tandfonline.com/doi/full/10.1080/07853890.2022.2107700 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6050 Risk factors for ophthalmologic involvement and ocular findings in patients diagnosed with fungemia in a high-complexity hospital in the city of Medellín, Colombia [documento electrónico] / Luis Fernando Velásquez Ossa, ; Jorge Hernando Donado Gómez, ; Laura Nataly Higuita Duque, . - 2022.
Obra : Annals of Medicine
Idioma : Inglés (eng)
Palabras clave : Fundus Oculi Fungemia candida retina Resumen : Purpose: To describe the demographic clinical characteristics and to identify the risk factors of patients diagnosed with fungemia and secondary intraocular involvement. Methods: Retrospective cohort of 97 patients diagnosed with fungemia and with or without involvement of the posterior segment. Demographic, clinical and ophthalmological variables were identified to establish the risk of retinal seeding. Results: An incidence of ocular involvement of 22.68% was obtained and no clear risk factor was found for subsequent showings in patients with fungemia. A risk trend was only found in patients with diabetes with an OR: 2.85; CI 95%: (0.80-10.12) and history of HIV with an OR: 2.29 CI95%: (0.85-6.12). Conclusions: In this first cohort carried out in Colombia according to our search, findings were obtained that agree with those of other authors worldwide, where there is no evidence of a decrease in incidence compared with older studies and the absence of risk factors for the compromise of the posterior pole in patients with fungemia.KEY MESSAGES Systematic fundus evaluation by an ophthalmologist in patients with candidaemia is a recommended practice based on low-quality evidence.The identification of real risk factors for retinal compromise in fungemia would allow us to be more selective with the population to be evaluated.Fungemia generally occurs in critically ill patients, where access and availability of ophthalmology evaluation are a resource that is not always available. Mención de responsabilidad : Marcos Restrepo Arango, Juan Camilo Cadavid Usuga, Luis Fernando Velazquez Ossa, Jorge Hernando Donado Gómez, Laura Nataly Higuita Duque, Juan Pedro Neira Gomez Referencia : Ann Med. 2022 Dec;54(1):2204-2210. DOI (Digital Object Identifier) : 10.1080/07853890.2022.2107700 Derechos de uso : CC BY En línea : https://www.tandfonline.com/doi/full/10.1080/07853890.2022.2107700 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6050 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001894 AC-2022-058 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-058Adobe Acrobat PDF Reproducibility of a protocol for standardized reading of chest X-rays of children household contact of patients with tuberculosis / Lina Marcela Cadavid Álvarez ; Lucila Beatriz Molinares Arevalo
Título : Reproducibility of a protocol for standardized reading of chest X-rays of children household contact of patients with tuberculosis Tipo de documento : documento electrónico Autores : Lina Marcela Cadavid Álvarez, ; Lucila Beatriz Molinares Arevalo, Fecha de publicación : 2022 Títulos uniformes : BMC Pediatrics Idioma : Inglés (eng) Palabras clave : Tuberculosis Pulmonary Latent Tuberculosis Clinical Protocols Radiography Thoracic Observer Variation Reproducibility of Results Resumen : Background: The interpretation of the chest radiograph may vary because it depends on the reader and due to the non-specificity of findings in tuberculosis (TB). We aim to assess the reproducibility of a standardized chest radiograph reading protocol in contacts of patients with pulmonary TB under the 5 years of age. Methods: Descriptive, cross-sectional study with children under the age of five, household contacts of patients with confirmed pulmonary TB from Medellín, Bello and Itagüí (Colombia) between Jan-01-2015 and May-31-2016. Standardized reading protocol: two radiologists, blinded independent reading, use of template (Dr. Andronikou design) in case of disagreement a third reading was performed. Kappa coefficient for intra and inter observer agreement, and prevalence ratio were estimated of sociodemographic characteristics, TB exposure and interpretation of chest X-ray. Results: From 278 children, standardized reading found 255 (91.7%) normal X-rays, 10 (3.6%) consistent with TB, and 13 (4.7%) other alterations. Global agreement was 91.3% (Kappa = 0.51). Inter-observer agreement between readers 1-2 was 90.0% (Kappa = 0.59) and 1-3 93.2% (Kappa = 0.59). Intra-observer agreement for reader 1 was 95.5% (Kappa = 0.86), 2 84.0% (Kappa = 0.51), and 3 94.7% (Kappa = 0.68). Greater inter-observer disagreement was between readers 1-2 for soft tissue density suggestive of adenopathy (4.6%), airspace opacification (1.17%) and pleural effusion (0.58%); between readers 1-3 for soft tissue density suggestive of adenopathy (4.2%), opacification of airspace (2.5%) and cavities (0.8%). Conclusions: Chest radiographs are an affordable tool that contributes to the diagnosis of TB, so having a standardized reading protocol showed good agreement and improves the reproducibility of radiograph interpretation. Mención de responsabilidad : María Margarita Lozano-Acosta, María Alejandra Rubiano-Arenas, Lina Marcela Cadavid, Guillermo Vélez-Parra, Beatriz Molinares, Diana Marcela Marín-Pineda, María Patricia Arbeláez-Montoya & Dione Benjumea-Bedoya Referencia : BMC Pediatr. 2022 May 24;22(1):307. DOI (Digital Object Identifier) : 10.1186/s12887-022-03347-6 PMID : 35610599 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03347-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6082 Reproducibility of a protocol for standardized reading of chest X-rays of children household contact of patients with tuberculosis [documento electrónico] / Lina Marcela Cadavid Álvarez, ; Lucila Beatriz Molinares Arevalo, . - 2022.
Obra : BMC Pediatrics
Idioma : Inglés (eng)
Palabras clave : Tuberculosis Pulmonary Latent Tuberculosis Clinical Protocols Radiography Thoracic Observer Variation Reproducibility of Results Resumen : Background: The interpretation of the chest radiograph may vary because it depends on the reader and due to the non-specificity of findings in tuberculosis (TB). We aim to assess the reproducibility of a standardized chest radiograph reading protocol in contacts of patients with pulmonary TB under the 5 years of age. Methods: Descriptive, cross-sectional study with children under the age of five, household contacts of patients with confirmed pulmonary TB from Medellín, Bello and Itagüí (Colombia) between Jan-01-2015 and May-31-2016. Standardized reading protocol: two radiologists, blinded independent reading, use of template (Dr. Andronikou design) in case of disagreement a third reading was performed. Kappa coefficient for intra and inter observer agreement, and prevalence ratio were estimated of sociodemographic characteristics, TB exposure and interpretation of chest X-ray. Results: From 278 children, standardized reading found 255 (91.7%) normal X-rays, 10 (3.6%) consistent with TB, and 13 (4.7%) other alterations. Global agreement was 91.3% (Kappa = 0.51). Inter-observer agreement between readers 1-2 was 90.0% (Kappa = 0.59) and 1-3 93.2% (Kappa = 0.59). Intra-observer agreement for reader 1 was 95.5% (Kappa = 0.86), 2 84.0% (Kappa = 0.51), and 3 94.7% (Kappa = 0.68). Greater inter-observer disagreement was between readers 1-2 for soft tissue density suggestive of adenopathy (4.6%), airspace opacification (1.17%) and pleural effusion (0.58%); between readers 1-3 for soft tissue density suggestive of adenopathy (4.2%), opacification of airspace (2.5%) and cavities (0.8%). Conclusions: Chest radiographs are an affordable tool that contributes to the diagnosis of TB, so having a standardized reading protocol showed good agreement and improves the reproducibility of radiograph interpretation. Mención de responsabilidad : María Margarita Lozano-Acosta, María Alejandra Rubiano-Arenas, Lina Marcela Cadavid, Guillermo Vélez-Parra, Beatriz Molinares, Diana Marcela Marín-Pineda, María Patricia Arbeláez-Montoya & Dione Benjumea-Bedoya Referencia : BMC Pediatr. 2022 May 24;22(1):307. DOI (Digital Object Identifier) : 10.1186/s12887-022-03347-6 PMID : 35610599 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03347-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6082 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001929 AC-2022-090 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-090Adobe Acrobat PDF Caracterización de los recién nacidos con síndrome de down según condiciones de salud, demográficas y sociales en Medellín del periodo 2015 a 2019 / Mauricio Fernández Laverde
Título : Caracterización de los recién nacidos con síndrome de down según condiciones de salud, demográficas y sociales en Medellín del periodo 2015 a 2019 Otros títulos : Characterization of newborns with Down Syndrome according to health, demographic and social conditions in Medellín from the period 2015 to 2019 Tipo de documento : documento electrónico Autores : Mauricio Fernández Laverde, Fecha de publicación : 2022 Títulos uniformes : CES Medicina Idioma : Español (spa) Palabras clave : Síndrome de Down recién nacido malformaciones congénitas trisomía Resumen : La adaptación de una atención especializada para recién nacidos con Síndrome de Down (SD) requiere el reconocimiento de sus características a nivel local. Objetivo: caracterizar los recién nacidos diagnosticados con SD y sus madres en unidades de atención materno infantil de la ciudad de Medellín. Adicionalmente, se exploraron factores asociados al diagnóstico oportuno antenatal. Método: estudio observacional descriptivo de tipo transversal con intención analítica basado en registros médicos de recién nacidos diagnosticados con SD en siete instituciones de Medellín, Antioquia entre enero de 2015 y diciembre de 2019 teniendo en cuenta variables tanto maternas como neonatales. Se realizó un análisis univariado mediante frecuencias absolutas y relativas, luego se realizó un análisis bivariado teniendo en cuenta los desenlaces neonatales según el acceso al control prenatal y el momento en el cual se realizó el diagnóstico (prenatal o neonatal) y finalmente se realizó un análisis multivariado para diagnóstico neonatal tardío. Resultados: el 50,2% de las madres al momento del parto tenía 35 años o menos, de estas el 59,9% pertenecía al régimen contributivo y el 83,4% realizó 4 controles prenatales (CPN) o más, a pesar de esto, se encontró que sólo el 33,7% tenían diagnóstico prenatal de SD. La mayoría (91,4%) de los neonatos tuvo diagnóstico de cardiopatía congénita y la estancia hospitalaria prolongada estuvo en relación a morbilidad relacionadas. Conclusión: el SD es una de las cromosomopatías más común en nuestro medio, la cual se puede diagnósticar de forma temprana. Sin embargo en nuestro estudio se pudo evidenciar que pese a la alta cobertura de CPN la frecuencia del diagnóstico antenatal es menor, lo cual requiere que estos controles sean realizados por personal médico entrenado en pacientes con este tipo de patología. Esto finalmente se va a ver reflejado en una mejor aceptación por parte de la familia hacia la llegada de un hijo con esta condición y por supuesto, mejor acceso a servicios de salud especializados. Mención de responsabilidad : Noreña Gómez, Sara Isabel; Quintero Salazar, Juliana; Posada Mazuera, Mariana; Reyes Iriarte, Martha Mónica; Velez Leal, Sara; Arboleda Gómez, Carolina; Gómez González, Andrea; Fernández Laverde, Mauricio; Bareño Silva, Jose DOI (Digital Object Identifier) : 10.21615/cesmedicina.6729 Derechos de uso : CC BY-NC-SA En línea : https://revistas.ces.edu.co/index.php/medicina/article/view/6729 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6120 Caracterización de los recién nacidos con síndrome de down según condiciones de salud, demográficas y sociales en Medellín del periodo 2015 a 2019 = Characterization of newborns with Down Syndrome according to health, demographic and social conditions in Medellín from the period 2015 to 2019 [documento electrónico] / Mauricio Fernández Laverde, . - 2022.
Obra : CES Medicina
Idioma : Español (spa)
Palabras clave : Síndrome de Down recién nacido malformaciones congénitas trisomía Resumen : La adaptación de una atención especializada para recién nacidos con Síndrome de Down (SD) requiere el reconocimiento de sus características a nivel local. Objetivo: caracterizar los recién nacidos diagnosticados con SD y sus madres en unidades de atención materno infantil de la ciudad de Medellín. Adicionalmente, se exploraron factores asociados al diagnóstico oportuno antenatal. Método: estudio observacional descriptivo de tipo transversal con intención analítica basado en registros médicos de recién nacidos diagnosticados con SD en siete instituciones de Medellín, Antioquia entre enero de 2015 y diciembre de 2019 teniendo en cuenta variables tanto maternas como neonatales. Se realizó un análisis univariado mediante frecuencias absolutas y relativas, luego se realizó un análisis bivariado teniendo en cuenta los desenlaces neonatales según el acceso al control prenatal y el momento en el cual se realizó el diagnóstico (prenatal o neonatal) y finalmente se realizó un análisis multivariado para diagnóstico neonatal tardío. Resultados: el 50,2% de las madres al momento del parto tenía 35 años o menos, de estas el 59,9% pertenecía al régimen contributivo y el 83,4% realizó 4 controles prenatales (CPN) o más, a pesar de esto, se encontró que sólo el 33,7% tenían diagnóstico prenatal de SD. La mayoría (91,4%) de los neonatos tuvo diagnóstico de cardiopatía congénita y la estancia hospitalaria prolongada estuvo en relación a morbilidad relacionadas. Conclusión: el SD es una de las cromosomopatías más común en nuestro medio, la cual se puede diagnósticar de forma temprana. Sin embargo en nuestro estudio se pudo evidenciar que pese a la alta cobertura de CPN la frecuencia del diagnóstico antenatal es menor, lo cual requiere que estos controles sean realizados por personal médico entrenado en pacientes con este tipo de patología. Esto finalmente se va a ver reflejado en una mejor aceptación por parte de la familia hacia la llegada de un hijo con esta condición y por supuesto, mejor acceso a servicios de salud especializados. Mención de responsabilidad : Noreña Gómez, Sara Isabel; Quintero Salazar, Juliana; Posada Mazuera, Mariana; Reyes Iriarte, Martha Mónica; Velez Leal, Sara; Arboleda Gómez, Carolina; Gómez González, Andrea; Fernández Laverde, Mauricio; Bareño Silva, Jose DOI (Digital Object Identifier) : 10.21615/cesmedicina.6729 Derechos de uso : CC BY-NC-SA En línea : https://revistas.ces.edu.co/index.php/medicina/article/view/6729 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6120 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001983 AC-2022-126 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-126Adobe Acrobat PDF Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace / Carlos Simón Duque Fisher ; Alejandro Vélez Hoyos ; Juan Pablo Dueñas Muñoz
Título : Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Juan Pablo Dueñas Muñoz, Fecha de publicación : 2022 Títulos uniformes : Endocrine Idioma : Inglés (eng) Palabras clave : Healthcare specialists Papillary thyroid carcinoma (PTC) Radiation ThyroSeq Thyroid cancer Resumen : Purpose: Exposure to ionizing radiation, especially during childhood, is a well-established risk factor for thyroid cancer. The vast majority of radiation-induced cancers are papillary carcinomas (PTCs). These tumors typically have gene fusions in contrast to point mutations prevalent in sporadic PTCs. The aim of this study was to investigate the molecular profiles of PTC patients with workplace exposure to ionizing radiation. Methods: A retrospective review of 543 patients who underwent surgery with diagnosis of PTC was performed. A cohort of nine healthcare specialists previously exposed to radiation sources during their professional practice was selected and analyzed using the ThyroSeq mutation panel for point mutations and gene fusions associated with thyroid cancer. Results: The molecular analysis of surgical samples of PTCs was informative and revealed genetic alterations in five patients. BRAF V600E was found in four (67%) cases whereas RET/PTC1 fusion in one (17%) and one sample (17%) was wild type for point mutations and fusions. One sample completely failed molecular analysis while two others were negative for genes fusions but failed DNA analysis; these three samples were excluded. Conclusions: In this limited cohort of healthcare workers exposed to low dose of ionizing radiation at the workplace and developed PTC, the molecular profiling determined BRAF V600E point mutation as the most common event, arguing against the role of workplace radiation exposure in the etiology of these tumors. Mención de responsabilidad : Carlos S. Duque, Alejandro Vélez, Jorge Cuartas, Fabian Jaimes, Juan Pablo Dueñas, Miguel Agudelo, Marina N. Nikiforova, Yuri E. Nikiforov & Vincenzo Condello Referencia : Endocrine. 2022 Apr;76(1):95-100. DOI (Digital Object Identifier) : 10.1007/s12020-021-02972-y PMID : 35094311 En línea : https://link.springer.com/article/10.1007/s12020-021-02972-y Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6009 Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace [documento electrónico] / Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Juan Pablo Dueñas Muñoz, . - 2022.
Obra : Endocrine
Idioma : Inglés (eng)
Palabras clave : Healthcare specialists Papillary thyroid carcinoma (PTC) Radiation ThyroSeq Thyroid cancer Resumen : Purpose: Exposure to ionizing radiation, especially during childhood, is a well-established risk factor for thyroid cancer. The vast majority of radiation-induced cancers are papillary carcinomas (PTCs). These tumors typically have gene fusions in contrast to point mutations prevalent in sporadic PTCs. The aim of this study was to investigate the molecular profiles of PTC patients with workplace exposure to ionizing radiation. Methods: A retrospective review of 543 patients who underwent surgery with diagnosis of PTC was performed. A cohort of nine healthcare specialists previously exposed to radiation sources during their professional practice was selected and analyzed using the ThyroSeq mutation panel for point mutations and gene fusions associated with thyroid cancer. Results: The molecular analysis of surgical samples of PTCs was informative and revealed genetic alterations in five patients. BRAF V600E was found in four (67%) cases whereas RET/PTC1 fusion in one (17%) and one sample (17%) was wild type for point mutations and fusions. One sample completely failed molecular analysis while two others were negative for genes fusions but failed DNA analysis; these three samples were excluded. Conclusions: In this limited cohort of healthcare workers exposed to low dose of ionizing radiation at the workplace and developed PTC, the molecular profiling determined BRAF V600E point mutation as the most common event, arguing against the role of workplace radiation exposure in the etiology of these tumors. Mención de responsabilidad : Carlos S. Duque, Alejandro Vélez, Jorge Cuartas, Fabian Jaimes, Juan Pablo Dueñas, Miguel Agudelo, Marina N. Nikiforova, Yuri E. Nikiforov & Vincenzo Condello Referencia : Endocrine. 2022 Apr;76(1):95-100. DOI (Digital Object Identifier) : 10.1007/s12020-021-02972-y PMID : 35094311 En línea : https://link.springer.com/article/10.1007/s12020-021-02972-y Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6009 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001844 AC-2022-015 Archivo digital Producción Científica Artículos científicos Disponible
Título : The "rSr’ ECG pattern" is not always a Brugada ECG pattern Tipo de documento : documento electrónico Autores : Andrés Felipe Miranda Arboleda, Fecha de publicación : 2022 Títulos uniformes : Journal of Cardiovascular Electrophysiology Idioma : Inglés (eng) Palabras clave : Brugada ECG pattern differential diagnosis rSr’ ECG pattern Mención de responsabilidad : Adrian Baranchuk, Bryce Alexander, Andrés F Miranda-Arboleda Referencia : J Cardiovasc Electrophysiol. 2022 Sep;33(9):2092-2093. DOI (Digital Object Identifier) : 10.1111/jce.15614 PMID : 35761753 En línea : https://onlinelibrary.wiley.com/doi/10.1111/jce.15614 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6041 The "rSr’ ECG pattern" is not always a Brugada ECG pattern [documento electrónico] / Andrés Felipe Miranda Arboleda, . - 2022.
Obra : Journal of Cardiovascular Electrophysiology
Idioma : Inglés (eng)
Palabras clave : Brugada ECG pattern differential diagnosis rSr’ ECG pattern Mención de responsabilidad : Adrian Baranchuk, Bryce Alexander, Andrés F Miranda-Arboleda Referencia : J Cardiovasc Electrophysiol. 2022 Sep;33(9):2092-2093. DOI (Digital Object Identifier) : 10.1111/jce.15614 PMID : 35761753 En línea : https://onlinelibrary.wiley.com/doi/10.1111/jce.15614 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6041 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001883 AC-2022-048 Archivo digital Producción Científica Artículos científicos Disponible Accuracy of an off-label transmitter and data manager paired with an intermittent scanned continuous glucose monitor in adults with type 1 diabetes / Carlos Esteban Builes Montaño
Título : Accuracy of an off-label transmitter and data manager paired with an intermittent scanned continuous glucose monitor in adults with type 1 diabetes Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, Autor Fecha de publicación : 2022 Títulos uniformes : Journal of Diabetes Science and Technology Idioma : Inglés (eng) Palabras clave : FreeStyle Libre MiaoMiao transmitter continuous glucose monitoring intermittent scanned glucose monitoring xDrip+ software Resumen : Background: This work evaluates the accuracy and agreement between the FreeStyle Libre sensor (FSL) and an off-label converted real-time continuous glucose monitor (c-rtCGM) device consisting of the MiaoMiao transmitter and the xDrip+ application which can be coupled to the FSL. Methods: Four weeks of glucose data were collected from 21 participants with type 1 diabetes using the c-rtCGM and FSL: two weeks with a single initial calibration (uncalibrated) and two weeks with a daily calibration (calibrated). Accuracy and agreement evaluation included mean absolute relative difference (MARD), the %20/20 rule, Bland-Altman plots, and the Consensus Error Grid analysis. Results: Values reported by the c-rtCGM system compared with the FSL resulted in an overall MARD of 12.06% and 84.71% of the results falling within Consensus Error Grid Zone A when the device is calibrated. For uncalibrated devices, an overall MARD of 17.49% was obtained. Decreased accuracy was shown in the hypoglycemic range and for rates of change greater than 2 mg/dL/min. The between-device bias also incremented with increasing glucose values. Conclusion: Measurements recorded by the c-rtCGM were found to be accurate when compared with FSL data only when performing daily c-rtCGM device calibrations. High drops in accuracy and agreement between devices occurred when the c-rtCGM was not calibrated. Mención de responsabilidad : María F Villa-Tamayo, Carlos E Builes-Montaño, Alex Ramirez-Rincón, Javier Carvajal Pablo S Rivadeneira Referencia : J Diabetes Sci Technol. 2022 Oct 25;19322968221133405. DOI (Digital Object Identifier) : 10.1177/19322968221133405 PMID : 36281579 En línea : https://journals.sagepub.com/doi/10.1177/19322968221133405 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6073 Accuracy of an off-label transmitter and data manager paired with an intermittent scanned continuous glucose monitor in adults with type 1 diabetes [documento electrónico] / Carlos Esteban Builes Montaño, Autor . - 2022.
Obra : Journal of Diabetes Science and Technology
Idioma : Inglés (eng)
Palabras clave : FreeStyle Libre MiaoMiao transmitter continuous glucose monitoring intermittent scanned glucose monitoring xDrip+ software Resumen : Background: This work evaluates the accuracy and agreement between the FreeStyle Libre sensor (FSL) and an off-label converted real-time continuous glucose monitor (c-rtCGM) device consisting of the MiaoMiao transmitter and the xDrip+ application which can be coupled to the FSL. Methods: Four weeks of glucose data were collected from 21 participants with type 1 diabetes using the c-rtCGM and FSL: two weeks with a single initial calibration (uncalibrated) and two weeks with a daily calibration (calibrated). Accuracy and agreement evaluation included mean absolute relative difference (MARD), the %20/20 rule, Bland-Altman plots, and the Consensus Error Grid analysis. Results: Values reported by the c-rtCGM system compared with the FSL resulted in an overall MARD of 12.06% and 84.71% of the results falling within Consensus Error Grid Zone A when the device is calibrated. For uncalibrated devices, an overall MARD of 17.49% was obtained. Decreased accuracy was shown in the hypoglycemic range and for rates of change greater than 2 mg/dL/min. The between-device bias also incremented with increasing glucose values. Conclusion: Measurements recorded by the c-rtCGM were found to be accurate when compared with FSL data only when performing daily c-rtCGM device calibrations. High drops in accuracy and agreement between devices occurred when the c-rtCGM was not calibrated. Mención de responsabilidad : María F Villa-Tamayo, Carlos E Builes-Montaño, Alex Ramirez-Rincón, Javier Carvajal Pablo S Rivadeneira Referencia : J Diabetes Sci Technol. 2022 Oct 25;19322968221133405. DOI (Digital Object Identifier) : 10.1177/19322968221133405 PMID : 36281579 En línea : https://journals.sagepub.com/doi/10.1177/19322968221133405 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6073 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001917 DD001917 Archivo digital Producción Científica Artículos científicos Disponible Insulinoma-related endogenous hypoglycaemia with a negative fasting test: a case report and literature review / Carolina Prieto Saldarriaga ; Carlos Esteban Builes Montaño ; Clara María Arango Toro
Título : Insulinoma-related endogenous hypoglycaemia with a negative fasting test: a case report and literature review Tipo de documento : documento electrónico Autores : Carolina Prieto Saldarriaga, ; Carlos Esteban Builes Montaño, ; Clara María Arango Toro, Fecha de publicación : 2022 Títulos uniformes : European Journal of Case Reports in Internal Medicine Idioma : Inglés (eng) Palabras clave : Insulinoma hyperinsulinaemia fasting Resumen : We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negative 72-hour fasting test with histological confirmation of insulinoma. A literature review of hyperinsulinaemic hypoglycaemia with a negative fasting test was performed. Mención de responsabilidad : Carolina Prieto-Saldarriaga, Carlos Esteban Builes-Montaño, Clara María Arango-Toro, Cindy Manotas-Echeverry, Juan Camilo Pérez-Cadavid, José C Álvarez-Payares, Luis Antonio Rodríguez-Arrieta Referencia : Eur J Case Rep Intern Med. 2022 Sep 9;9(9):003484. DOI (Digital Object Identifier) : 10.12890/2022_003484 PMID : 36299851 En línea : https://www.ejcrim.com/index.php/EJCRIM/article/view/3484 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6105 Insulinoma-related endogenous hypoglycaemia with a negative fasting test: a case report and literature review [documento electrónico] / Carolina Prieto Saldarriaga, ; Carlos Esteban Builes Montaño, ; Clara María Arango Toro, . - 2022.
Obra : European Journal of Case Reports in Internal Medicine
Idioma : Inglés (eng)
Palabras clave : Insulinoma hyperinsulinaemia fasting Resumen : We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negative 72-hour fasting test with histological confirmation of insulinoma. A literature review of hyperinsulinaemic hypoglycaemia with a negative fasting test was performed. Mención de responsabilidad : Carolina Prieto-Saldarriaga, Carlos Esteban Builes-Montaño, Clara María Arango-Toro, Cindy Manotas-Echeverry, Juan Camilo Pérez-Cadavid, José C Álvarez-Payares, Luis Antonio Rodríguez-Arrieta Referencia : Eur J Case Rep Intern Med. 2022 Sep 9;9(9):003484. DOI (Digital Object Identifier) : 10.12890/2022_003484 PMID : 36299851 En línea : https://www.ejcrim.com/index.php/EJCRIM/article/view/3484 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6105 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001953 AC-2022-114 Archivo digital Producción Científica Artículos científicos Disponible
Título : Effectiveness of an online course on fracture-related infections Tipo de documento : documento electrónico Autores : Carlos Oliver Valderrama Molina, Fecha de publicación : 2022 Títulos uniformes : Journal of European CME Idioma : Inglés (eng) Palabras clave : Medical education medical meetings electronic learning educational intervention fracture-related infection Resumen : This study aims to evaluate the effectiveness of an online course to enable orthopaedic surgeons to acquire the core competencies necessary to prevent and treat fracture-related infections (FRI). This study included orthopaedic surgeons and residents from Latin American countries who attended an online course focused on FRI. The online course included: didactic lectures, small-group clinical case discussions, and panel case discussions. The course was delivered using Zoom® platform and designed to address four core competencies: prevention, definition and diagnosis, antimicrobial therapy, and surgical treatment. An online questionnaire was created distributing 16 questions through six clinical scenarios. Participants were invited to answer the questionnaire before and after the course. Sixty of the 78 course participants answered the pre-course, and 42 the post-course assessment. Relative to before the course, the mean post-course assessment score rose significantly for prevention of FRI (4.1 before and 4.5 after; p = 0.014), definition and diagnosis (2.4 before and 3.4 after; p = 0.001), and surgical treatment (2.2 before and 2.8 after; p = 0.011). The final score encompassing all four core competencies also rose significantly (2.7 before and 3.3 after; p = 0.001). The online course on FRI was feasible and effective, significantly increasing course users’ knowledge of overall competency in managing FRI. Mención de responsabilidad : Matheus Lemos Azi, Kodi Edson Kojima, Rodrigo Pesántez, Guido Carabelli, Olivier Borense, Iain McFadyen and Carlos Oliver Valderrama-Molina Referencia : J Eur CME. 2022 Jan 10;11(1):2024682. DOI (Digital Object Identifier) : 10.1080/21614083.2021.2024682 PMID : 35036049 Derechos de uso : CC BY-NC En línea : https://www.tandfonline.com/doi/full/10.1080/21614083.2021.2024682 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6000 Effectiveness of an online course on fracture-related infections [documento electrónico] / Carlos Oliver Valderrama Molina, . - 2022.
Obra : Journal of European CME
Idioma : Inglés (eng)
Palabras clave : Medical education medical meetings electronic learning educational intervention fracture-related infection Resumen : This study aims to evaluate the effectiveness of an online course to enable orthopaedic surgeons to acquire the core competencies necessary to prevent and treat fracture-related infections (FRI). This study included orthopaedic surgeons and residents from Latin American countries who attended an online course focused on FRI. The online course included: didactic lectures, small-group clinical case discussions, and panel case discussions. The course was delivered using Zoom® platform and designed to address four core competencies: prevention, definition and diagnosis, antimicrobial therapy, and surgical treatment. An online questionnaire was created distributing 16 questions through six clinical scenarios. Participants were invited to answer the questionnaire before and after the course. Sixty of the 78 course participants answered the pre-course, and 42 the post-course assessment. Relative to before the course, the mean post-course assessment score rose significantly for prevention of FRI (4.1 before and 4.5 after; p = 0.014), definition and diagnosis (2.4 before and 3.4 after; p = 0.001), and surgical treatment (2.2 before and 2.8 after; p = 0.011). The final score encompassing all four core competencies also rose significantly (2.7 before and 3.3 after; p = 0.001). The online course on FRI was feasible and effective, significantly increasing course users’ knowledge of overall competency in managing FRI. Mención de responsabilidad : Matheus Lemos Azi, Kodi Edson Kojima, Rodrigo Pesántez, Guido Carabelli, Olivier Borense, Iain McFadyen and Carlos Oliver Valderrama-Molina Referencia : J Eur CME. 2022 Jan 10;11(1):2024682. DOI (Digital Object Identifier) : 10.1080/21614083.2021.2024682 PMID : 35036049 Derechos de uso : CC BY-NC En línea : https://www.tandfonline.com/doi/full/10.1080/21614083.2021.2024682 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6000 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001827 AC-2022-006 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-006Adobe Acrobat PDF Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America / Laura Fernanda Niño Serna ; Eliana López Barón ; Isabel Cristina Maya Ángel ; Carolina Tamayo Múnera
Título : Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, ; Eliana López Barón, ; Isabel Cristina Maya Ángel, ; Carolina Tamayo Múnera, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatrics comorbidity inpatients pediatric intensive care unit Latin America COVID-19 Resumen : Objective: COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia. Method: A descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality. Results: A total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients). Conclusions: The majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative. Mención de responsabilidad : Laura F. Niño-Serna, Eliana López-Barón, Isabel Cristina Maya Ángel and Carolina Tamayo-Múnera Referencia : Front Pediatr. 2022 Jun 9;10:921880. DOI (Digital Object Identifier) : 10.3389/fped.2022.921880 PMID : 35757135 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.921880/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6032 Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America [documento electrónico] / Laura Fernanda Niño Serna, ; Eliana López Barón, ; Isabel Cristina Maya Ángel, ; Carolina Tamayo Múnera, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatrics comorbidity inpatients pediatric intensive care unit Latin America COVID-19 Resumen : Objective: COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia. Method: A descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality. Results: A total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients). Conclusions: The majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative. Mención de responsabilidad : Laura F. Niño-Serna, Eliana López-Barón, Isabel Cristina Maya Ángel and Carolina Tamayo-Múnera Referencia : Front Pediatr. 2022 Jun 9;10:921880. DOI (Digital Object Identifier) : 10.3389/fped.2022.921880 PMID : 35757135 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.921880/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6032 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001874 AC-2022-039 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-039Adobe Acrobat PDF Actualización en lesión renal aguda inducida por contraste en pediatría / Catalina Vélez Echeverri ; Carolina Lucía Ochoa García ; Juan José Vanegas Ruiz
Título : Actualización en lesión renal aguda inducida por contraste en pediatría Otros títulos : Update on contrast-induced acute kidney injury in pediatrics Tipo de documento : documento electrónico Autores : Catalina Vélez Echeverri, ; Carolina Lucía Ochoa García, ; Juan José Vanegas Ruiz, Fecha de publicación : 2022 Títulos uniformes : Revista Colombiana de Nefrología Idioma : Español (spa) Palabras clave : medios de contraste enfermedades renales enfermedad renal crónica creatinina Resumen : Contexto: la lesión renal aguda inducida por contraste se ha convertido en un tema de gran interés en la comunidad médica a nivel mundial, siendo la tercera causa de lesión renal aguda adquirida en el hospital. Objetivo: el presente artículo presenta una revisión de la literatura con el fin de actualizar los conceptos de esta patología en el personal de la salud que está en contacto con la población pediátrica y que es sometida a procedimientos con medios de contraste. Metodología: en esta revisión narrativa de la literatura, presentamos la definición, los factores de riesgo, el enfoque clínico y las medidas preventivas de la nefropatía inducida por contraste en pediatría. Resultados: se define que hay un deterioro en la función renal aguda después de la administración del medio de contraste en donde se excluyen otras posibles etiologías y se establece una verdadera relación causal con la sustancia. Los factores de riesgo son múltiples, sin embargo, factores estrictamente relacionados en los niños no han sido establecidos en su totalidad. El abordaje de los pacientes que van a ser sometidos a estudios con medios de contraste inicia desde una historia clínica, un examen físico y unas medidas de laboratorio que permiten evaluar el estado basal de cada paciente para instaurar medidas preventivas. Por su parte, las estrategias de prevención de esta condición son múltiples, sin embargo, no existen guías basadas en la evidencia acerca de esta condición en el paciente pediátrico. Conclusiones: el artículo presenta una revisión de la literatura sobre lesión renal aguda para actualizar los conceptos de esta patología en el personal de la salud que está en contacto con la población pediátrica que se somete a procedimientos con medios de contraste. Mención de responsabilidad : Andrés David Aranzazu Ceballos, Valentina Herrera Mejía, Catalina Vélez Echeverri, Carolina Lucía Ochoa García y Juan José Vanegas Ruiz DOI (Digital Object Identifier) : 10.22265/acnef.9.3.584 Derechos de uso : CC BY-NC-ND En línea : https://www.revistanefrologia.org/index.php/rcn/article/view/584 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6064 Actualización en lesión renal aguda inducida por contraste en pediatría = Update on contrast-induced acute kidney injury in pediatrics [documento electrónico] / Catalina Vélez Echeverri, ; Carolina Lucía Ochoa García, ; Juan José Vanegas Ruiz, . - 2022.
Obra : Revista Colombiana de Nefrología
Idioma : Español (spa)
Palabras clave : medios de contraste enfermedades renales enfermedad renal crónica creatinina Resumen : Contexto: la lesión renal aguda inducida por contraste se ha convertido en un tema de gran interés en la comunidad médica a nivel mundial, siendo la tercera causa de lesión renal aguda adquirida en el hospital. Objetivo: el presente artículo presenta una revisión de la literatura con el fin de actualizar los conceptos de esta patología en el personal de la salud que está en contacto con la población pediátrica y que es sometida a procedimientos con medios de contraste. Metodología: en esta revisión narrativa de la literatura, presentamos la definición, los factores de riesgo, el enfoque clínico y las medidas preventivas de la nefropatía inducida por contraste en pediatría. Resultados: se define que hay un deterioro en la función renal aguda después de la administración del medio de contraste en donde se excluyen otras posibles etiologías y se establece una verdadera relación causal con la sustancia. Los factores de riesgo son múltiples, sin embargo, factores estrictamente relacionados en los niños no han sido establecidos en su totalidad. El abordaje de los pacientes que van a ser sometidos a estudios con medios de contraste inicia desde una historia clínica, un examen físico y unas medidas de laboratorio que permiten evaluar el estado basal de cada paciente para instaurar medidas preventivas. Por su parte, las estrategias de prevención de esta condición son múltiples, sin embargo, no existen guías basadas en la evidencia acerca de esta condición en el paciente pediátrico. Conclusiones: el artículo presenta una revisión de la literatura sobre lesión renal aguda para actualizar los conceptos de esta patología en el personal de la salud que está en contacto con la población pediátrica que se somete a procedimientos con medios de contraste. Mención de responsabilidad : Andrés David Aranzazu Ceballos, Valentina Herrera Mejía, Catalina Vélez Echeverri, Carolina Lucía Ochoa García y Juan José Vanegas Ruiz DOI (Digital Object Identifier) : 10.22265/acnef.9.3.584 Derechos de uso : CC BY-NC-ND En línea : https://www.revistanefrologia.org/index.php/rcn/article/view/584 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6064 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001908 AC-2022-072 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-072Adobe Acrobat PDF
Título : Complejo de Carney: reporte de un caso y revisión de la literatura Otros títulos : Carney complex: a case report and literature review Tipo de documento : documento electrónico Autores : Carolina Prieto Saldarriaga, Fecha de publicación : 2022 Títulos uniformes : Iatreia Idioma : Español (spa) Palabras clave : acromegalia complejo de Carney mixoma schwannomas síndrome de Cushing Resumen : El complejo de Carney es una enfermedad caracterizada por lesiones en la piel, tumores endocrinos, ardiacos, gonadales y en otros órganos, que está asociada con mutaciones del gen PRKAR1A. Presentamos el caso clínico de una paciente con varias de las manifestaciones más características de este síndrome. Finalmente, se hace una revisión de la literatura. Mención de responsabilidad : Johnayro Gutiérrez-Restrepo, Carolina Aguilar-Londoño, Carolina Prieto-Saldarriaga DOI (Digital Object Identifier) : 10.17533/udea.iatreia.123 Derechos de uso : CC BY-NC-SA En línea : https://revistas.udea.edu.co/index.php/iatreia/article/view/346628 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6096 Complejo de Carney: reporte de un caso y revisión de la literatura = Carney complex: a case report and literature review [documento electrónico] / Carolina Prieto Saldarriaga, . - 2022.
Obra : Iatreia
Idioma : Español (spa)
Palabras clave : acromegalia complejo de Carney mixoma schwannomas síndrome de Cushing Resumen : El complejo de Carney es una enfermedad caracterizada por lesiones en la piel, tumores endocrinos, ardiacos, gonadales y en otros órganos, que está asociada con mutaciones del gen PRKAR1A. Presentamos el caso clínico de una paciente con varias de las manifestaciones más características de este síndrome. Finalmente, se hace una revisión de la literatura. Mención de responsabilidad : Johnayro Gutiérrez-Restrepo, Carolina Aguilar-Londoño, Carolina Prieto-Saldarriaga DOI (Digital Object Identifier) : 10.17533/udea.iatreia.123 Derechos de uso : CC BY-NC-SA En línea : https://revistas.udea.edu.co/index.php/iatreia/article/view/346628 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6096 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001944 AC-2022-105 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-105Adobe Acrobat PDF Real-world evidence of epidemiology and clinical outcomes in multiple myeloma, findings from the registry of hemato-oncologic malignancies in Colombia, observational study / Kenny Mauricio Gálvez Cárdenas
Título : Real-world evidence of epidemiology and clinical outcomes in multiple myeloma, findings from the registry of hemato-oncologic malignancies in Colombia, observational study Tipo de documento : documento electrónico Autores : Kenny Mauricio Gálvez Cárdenas, Fecha de publicación : 2022 Títulos uniformes : Clinical Lymphoma, Myeloma & Leukemia Idioma : Inglés (eng) Palabras clave : Multiple myeloma Colombia Diagnosis Therapy autologous transplantation disease registry real-world Resumen : Multiple Myeloma (MM) is a plasma cell derived clonal disorder that represents around 1% of all newly diagnosed neoplasms. Limited data regarding MM treatment in Latin America is available, and access to novel agents for a substantial portion of the population is limited by their high costs. 1 . In this multicenter cohort study, data on 890 Colombian MM patients are reported with a median follow-up of 18 months (IQR: 7-42 months). Patients were classified by age group (≤ or > 65 years). Median age at diagnosis was 67 years (IQR: 59-75 years) and 47.1% of patients were women. 709 patients (79.6%) received Bortezomib-based schemes as part of the first line, with Cyclophosphamide-Bortezomib-Dexamethasone (CyBorD) being the most frequently used (301 patients; 33.8%). Only two hundred and fifty-two patients (28.3%) were consolidated with Autologous Stem Cell Transplantation (ASCT) in first-line therapy. ASCT consolidation and age were the main independent factors influencing outcomes; in the non-ASCT cohort, 5-year overall survival was 48.7% (CI 41.8-55.2) compared to 80.7% (CI 73-86.4) in ASCT patients. This data depicts the reality of MM in Colombia, which likely reflects other Latin American countries, where access barriers to diagnosis and treatment are echoed in advanced stage diagnosis and a low rate of transplants. These seem to negatively impact survival despite the availability of most novel drugs approved in most of the world for this disease. Thus, emphasizing the paradox that prevails in most of the region: availability without equitable access. Mención de responsabilidad : Virginia Abello, William Armando Mantilla, Henry Idrobo, Claudia Lucia Sossa, Luis Antonio Salazar, Angela Pena, Juan Manuel Herrera, Paola Guerrero, Daniel Espinosa, Guillermo Enrique Quintero-Vega, Isabel Munevar, Kenny Galvez, Alicia Henao, Rigoberto Gómez, Jose Domingo Saavedra, Lina María Gaviria, Mónica Osuna y María Victoria Mateos Referencia : Clin Lymphoma Myeloma Leuk. 2021 Dec 13;S2152-2650(21)02478-2. DOI (Digital Object Identifier) : 10.1016/j.clml.2021.12.009 PMID : 35042679 En línea : https://linkinghub.elsevier.com/retrieve/pii/S2152265021024782 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5841 Real-world evidence of epidemiology and clinical outcomes in multiple myeloma, findings from the registry of hemato-oncologic malignancies in Colombia, observational study [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, . - 2022.
Obra : Clinical Lymphoma, Myeloma & Leukemia
Idioma : Inglés (eng)
Palabras clave : Multiple myeloma Colombia Diagnosis Therapy autologous transplantation disease registry real-world Resumen : Multiple Myeloma (MM) is a plasma cell derived clonal disorder that represents around 1% of all newly diagnosed neoplasms. Limited data regarding MM treatment in Latin America is available, and access to novel agents for a substantial portion of the population is limited by their high costs. 1 . In this multicenter cohort study, data on 890 Colombian MM patients are reported with a median follow-up of 18 months (IQR: 7-42 months). Patients were classified by age group (≤ or > 65 years). Median age at diagnosis was 67 years (IQR: 59-75 years) and 47.1% of patients were women. 709 patients (79.6%) received Bortezomib-based schemes as part of the first line, with Cyclophosphamide-Bortezomib-Dexamethasone (CyBorD) being the most frequently used (301 patients; 33.8%). Only two hundred and fifty-two patients (28.3%) were consolidated with Autologous Stem Cell Transplantation (ASCT) in first-line therapy. ASCT consolidation and age were the main independent factors influencing outcomes; in the non-ASCT cohort, 5-year overall survival was 48.7% (CI 41.8-55.2) compared to 80.7% (CI 73-86.4) in ASCT patients. This data depicts the reality of MM in Colombia, which likely reflects other Latin American countries, where access barriers to diagnosis and treatment are echoed in advanced stage diagnosis and a low rate of transplants. These seem to negatively impact survival despite the availability of most novel drugs approved in most of the world for this disease. Thus, emphasizing the paradox that prevails in most of the region: availability without equitable access. Mención de responsabilidad : Virginia Abello, William Armando Mantilla, Henry Idrobo, Claudia Lucia Sossa, Luis Antonio Salazar, Angela Pena, Juan Manuel Herrera, Paola Guerrero, Daniel Espinosa, Guillermo Enrique Quintero-Vega, Isabel Munevar, Kenny Galvez, Alicia Henao, Rigoberto Gómez, Jose Domingo Saavedra, Lina María Gaviria, Mónica Osuna y María Victoria Mateos Referencia : Clin Lymphoma Myeloma Leuk. 2021 Dec 13;S2152-2650(21)02478-2. DOI (Digital Object Identifier) : 10.1016/j.clml.2021.12.009 PMID : 35042679 En línea : https://linkinghub.elsevier.com/retrieve/pii/S2152265021024782 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5841 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001776 AC-2021-091 Archivo digital Producción Científica Artículos científicos Disponible Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis / Arbey Aristizabal Álzate ; John Fredy Nieto Ríos ; Catalina Ocampo Kohn ; Dahyana Cadavid Aljure ; Martín Ochoa Escudero ; Gustavo Adolfo Zuluaga Valencia
Título : Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis Otros títulos : Destructive noninfectious spondyloarthropathy in a hemodialysis patient Tipo de documento : documento electrónico Autores : Arbey Aristizabal Álzate, ; John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Dahyana Cadavid Aljure, ; Martín Ochoa Escudero, ; Gustavo Adolfo Zuluaga Valencia, Fecha de publicación : 2022 Títulos uniformes : Acta Médica Colombiana Idioma : Español (spa) Palabras clave : espondiloartropatía destructiva enfermedad renal crónica diálisis paraplejia Resumen : La espondiloartropatía destructiva es una patología osteoarticular presente en algunos pacientes con enfermedad crónica que puede afectar varios niveles de la columna vertebral y puede ser asintomática, generar dolor o causar complicaciones que ponen en peligro la integridad de la médula espinal y/o la vida. Presentamos el caso de un hombre de 70 años con enfermedad renal crónica terminal en hemodiálisis quien consultó por dolor dorsal y paraplejia, en quien se diagnosticó espondiloartropatía destructiva no infecciosa por imágenes y estudio histopatológico. Este caso nos muestra la importancia de pensar en esta patología y la necesidad de un enfoque multidisciplinario en el diagnóstico y manejo. Mención de responsabilidad : Arbey Aristizabal-Alzate, Kelly Johanna Betancur-Salazar, John Fredy Nieto-Ríos, Catalina Ocampo-Kohn, Dahyana Cadavid-Aljure, Martin Ochoa-Escudero, Gustavo Zuluaga-Valencia, Lina María Serna Higuita Referencia : Acta méd. colomb ; 47(1): 44-48, ene.-mar. 2022. DOI (Digital Object Identifier) : 10.36104/amc.2022.2193 Derechos de uso : CC BY En línea : http://www.actamedicacolombiana.com/ojs/index.php/actamed/article/view/2193 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6023 Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis = Destructive noninfectious spondyloarthropathy in a hemodialysis patient [documento electrónico] / Arbey Aristizabal Álzate, ; John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Dahyana Cadavid Aljure, ; Martín Ochoa Escudero, ; Gustavo Adolfo Zuluaga Valencia, . - 2022.
Obra : Acta Médica Colombiana
Idioma : Español (spa)
Palabras clave : espondiloartropatía destructiva enfermedad renal crónica diálisis paraplejia Resumen : La espondiloartropatía destructiva es una patología osteoarticular presente en algunos pacientes con enfermedad crónica que puede afectar varios niveles de la columna vertebral y puede ser asintomática, generar dolor o causar complicaciones que ponen en peligro la integridad de la médula espinal y/o la vida. Presentamos el caso de un hombre de 70 años con enfermedad renal crónica terminal en hemodiálisis quien consultó por dolor dorsal y paraplejia, en quien se diagnosticó espondiloartropatía destructiva no infecciosa por imágenes y estudio histopatológico. Este caso nos muestra la importancia de pensar en esta patología y la necesidad de un enfoque multidisciplinario en el diagnóstico y manejo. Mención de responsabilidad : Arbey Aristizabal-Alzate, Kelly Johanna Betancur-Salazar, John Fredy Nieto-Ríos, Catalina Ocampo-Kohn, Dahyana Cadavid-Aljure, Martin Ochoa-Escudero, Gustavo Zuluaga-Valencia, Lina María Serna Higuita Referencia : Acta méd. colomb ; 47(1): 44-48, ene.-mar. 2022. DOI (Digital Object Identifier) : 10.36104/amc.2022.2193 Derechos de uso : CC BY En línea : http://www.actamedicacolombiana.com/ojs/index.php/actamed/article/view/2193 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6023 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001863 AC-2022-029 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-029Adobe Acrobat PDF Reacciones adversas medicamentosas cutáneas: enfoque en el servicio de urgencias / Alejandra Zuluaga Restrepo
Título : Reacciones adversas medicamentosas cutáneas: enfoque en el servicio de urgencias Otros títulos : Drug eruptions: an emergency room approach Tipo de documento : documento electrónico Autores : Alejandra Zuluaga Restrepo, Fecha de publicación : 2022 Títulos uniformes : Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica Idioma : Español (spa) Palabras clave : Erupciones por medicamentos Necrólisis epidérmica tóxica Síndrome de hipersensibilidad a medicamentos Síndrome de Stevens-Johnson Resumen : Las erupciones cutáneas están dentro de las reacciones adversas medicamentosas más frecuentes; por lo tanto, es habitual enfrentarse a estas en los diferentes ámbitos del ejercicio médico. Un enfoque ordenado basado en la identificación temprana del posible agente etiológico, la cronología de la exposición y las características clínicas de la reacción permiten categorizar la gravedad del cuadro. Con una sospecha clara puede optimizarse la toma de paraclínicos, elegirse el nivel de complejidad asistencial más adecuado y tomarse las medidas terapéuticas y preventivas pertinentes para cada caso. En la siguiente revisión narrativa se pretende abarcar los aspectos clave de las erupciones medicamentosas más graves y proponer un enfoque simple de estas en el servicio de urgencias. Mención de responsabilidad : Simón Gallo-Echeverri, María Camila Gallo-Echeverri, Luis Gabriel Caicedo-Bello, Alejandra Zuluaga-Restrepo, Marie Claire Berrouet-Mejía En línea : https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1728 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6055 Reacciones adversas medicamentosas cutáneas: enfoque en el servicio de urgencias = Drug eruptions: an emergency room approach [documento electrónico] / Alejandra Zuluaga Restrepo, . - 2022.
Obra : Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
Idioma : Español (spa)
Palabras clave : Erupciones por medicamentos Necrólisis epidérmica tóxica Síndrome de hipersensibilidad a medicamentos Síndrome de Stevens-Johnson Resumen : Las erupciones cutáneas están dentro de las reacciones adversas medicamentosas más frecuentes; por lo tanto, es habitual enfrentarse a estas en los diferentes ámbitos del ejercicio médico. Un enfoque ordenado basado en la identificación temprana del posible agente etiológico, la cronología de la exposición y las características clínicas de la reacción permiten categorizar la gravedad del cuadro. Con una sospecha clara puede optimizarse la toma de paraclínicos, elegirse el nivel de complejidad asistencial más adecuado y tomarse las medidas terapéuticas y preventivas pertinentes para cada caso. En la siguiente revisión narrativa se pretende abarcar los aspectos clave de las erupciones medicamentosas más graves y proponer un enfoque simple de estas en el servicio de urgencias. Mención de responsabilidad : Simón Gallo-Echeverri, María Camila Gallo-Echeverri, Luis Gabriel Caicedo-Bello, Alejandra Zuluaga-Restrepo, Marie Claire Berrouet-Mejía En línea : https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1728 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6055 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001899 AC-2022-063 Archivo digital Producción Científica Artículos científicos Disponible