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Neumomediastino en trauma contuso: ¿son siempre necesarios los estudios invasivos para descartar lesión aerodigestiva? / Lina María Velásquez Gómez ; David Alejandro Mejía Toro ; César Andrés Ortega Toscano
Título : Neumomediastino en trauma contuso: ¿son siempre necesarios los estudios invasivos para descartar lesión aerodigestiva? Otros títulos : Pneumomediastinum in blunt trauma: Are invasive studies always necessary to rule out aerodigestive injury? Tipo de documento : documento electrónico Autores : Lina María Velásquez Gómez, ; David Alejandro Mejía Toro, ; César Andrés Ortega Toscano, Fecha de publicación : 2022 Títulos uniformes : Revista Colombiana de Cirugía Idioma : Español (spa) Palabras clave : trauma no penetrante tórax mediastino tráquea perforación del esófago Resumen : Introducción. La presencia de neumomediastino secundario a un trauma contuso es un hallazgo común, especialmente con el uso rutinario de la tomografía computarizada. Aunque en la mayoría de los casos es secundario a una causa benigna, la posibilidad de una lesión aerodigestiva subyacente ha llevado a que se recomiende el uso rutinario de estudios endoscópicos para descartarla. El propósito de este estudio fue determinar la incidencia de neumomediastino secundario a trauma contuso y de lesiones aerodigestivas asociadas y establecer la utilidad de la tomografía computarizada multidetector en el diagnóstico de las lesiones aerodigestivas. Métodos. Mediante tomografía computarizada multidetector se identificaron los pacientes con diagnóstico de neumomediastino secundario a un trauma contuso en un periodo de 4 años en un Centro de Trauma Nivel I. Resultados. Fueron incluidos en el estudio 41 pacientes con diagnóstico de neumomediastino secundario a un trauma contuso. Se documentaron en total tres lesiones aerodigestivas, dos lesiones traqueales y una esofágica. Dos de estas fueron sospechadas en tomografía computarizada multidetector y confirmadas mediante fibrobroncoscopia y endoscopia digestiva superior, respectivamente, y otra fue diagnosticada en cirugía. Conclusión. El uso rutinario de estudios endoscópicos en los pacientes con neumomediastino secundario a trauma contuso no está indicado cuando los hallazgos clínicos y tomográficos son poco sugestivos de lesión aerodigestiva. Mención de responsabilidad : Santiago Salazar-Ochoa, Pablo Posada-Moreno, Natalia Guzmán-Arango, Lina María Velásquez-Gomez, David Alejandro Mejía-Toro, Cesar Andrés Ortega-Toscano, Alejandro Montoya-Arboleda, Juan Diego Henao-Ayora Referencia : Rev. colomb. cir ; 37(2): 237-244, 20220316. DOI (Digital Object Identifier) : 10.30944/20117582.1150 Derechos de uso : CC BY-NC-ND En línea : https://www.revistacirugia.org/index.php/cirugia/article/view/1150 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6049 Neumomediastino en trauma contuso: ¿son siempre necesarios los estudios invasivos para descartar lesión aerodigestiva? = Pneumomediastinum in blunt trauma: Are invasive studies always necessary to rule out aerodigestive injury? [documento electrónico] / Lina María Velásquez Gómez, ; David Alejandro Mejía Toro, ; César Andrés Ortega Toscano, . - 2022.
Obra : Revista Colombiana de Cirugía
Idioma : Español (spa)
Palabras clave : trauma no penetrante tórax mediastino tráquea perforación del esófago Resumen : Introducción. La presencia de neumomediastino secundario a un trauma contuso es un hallazgo común, especialmente con el uso rutinario de la tomografía computarizada. Aunque en la mayoría de los casos es secundario a una causa benigna, la posibilidad de una lesión aerodigestiva subyacente ha llevado a que se recomiende el uso rutinario de estudios endoscópicos para descartarla. El propósito de este estudio fue determinar la incidencia de neumomediastino secundario a trauma contuso y de lesiones aerodigestivas asociadas y establecer la utilidad de la tomografía computarizada multidetector en el diagnóstico de las lesiones aerodigestivas. Métodos. Mediante tomografía computarizada multidetector se identificaron los pacientes con diagnóstico de neumomediastino secundario a un trauma contuso en un periodo de 4 años en un Centro de Trauma Nivel I. Resultados. Fueron incluidos en el estudio 41 pacientes con diagnóstico de neumomediastino secundario a un trauma contuso. Se documentaron en total tres lesiones aerodigestivas, dos lesiones traqueales y una esofágica. Dos de estas fueron sospechadas en tomografía computarizada multidetector y confirmadas mediante fibrobroncoscopia y endoscopia digestiva superior, respectivamente, y otra fue diagnosticada en cirugía. Conclusión. El uso rutinario de estudios endoscópicos en los pacientes con neumomediastino secundario a trauma contuso no está indicado cuando los hallazgos clínicos y tomográficos son poco sugestivos de lesión aerodigestiva. Mención de responsabilidad : Santiago Salazar-Ochoa, Pablo Posada-Moreno, Natalia Guzmán-Arango, Lina María Velásquez-Gomez, David Alejandro Mejía-Toro, Cesar Andrés Ortega-Toscano, Alejandro Montoya-Arboleda, Juan Diego Henao-Ayora Referencia : Rev. colomb. cir ; 37(2): 237-244, 20220316. DOI (Digital Object Identifier) : 10.30944/20117582.1150 Derechos de uso : CC BY-NC-ND En línea : https://www.revistacirugia.org/index.php/cirugia/article/view/1150 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6049 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001893 AC-2022-057 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-057Adobe Acrobat PDF Detecting Parkinson’s disease and its cognitive phenotypes via automated semantic analyses of action stories / Leonardo Fabio Moreno Gómez
Título : Detecting Parkinson’s disease and its cognitive phenotypes via automated semantic analyses of action stories Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2022 Títulos uniformes : NPJ Parkinson's Disease Idioma : Inglés (eng) Resumen : Action-concept outcomes are useful targets to identify Parkinson’s disease (PD) patients and differentiate between those with and without mild cognitive impairment (PD-MCI, PD-nMCI). Yet, most approaches employ burdensome examiner-dependent tasks, limiting their utility. We introduce a framework capturing action-concept markers automatically in natural speech. Patients from both subgroups and controls retold an action-laden and a non-action-laden text (AT, nAT). In each retelling, we weighed action and non-action concepts through our automated Proximity-to-Reference-Semantic-Field (P-RSF) metric, for analysis via ANCOVAs (controlling for cognitive dysfunction) and support vector machines. Patients were differentiated from controls based on AT (but not nAT) P-RSF scores. The same occurred in PD-nMCI patients. Conversely, PD-MCI patients exhibited reduced P-RSF scores for both texts. Direct discrimination between patient subgroups was not systematic, but it yielded best outcomes via AT scores. Our approach outperformed classifiers based on corpus-derived embeddings. This framework opens scalable avenues to support PD diagnosis and phenotyping. Mención de responsabilidad : Adolfo M. García, Daniel Escobar-Grisales, Juan Camilo Vásquez Correa, Yamile Bocanegra, Leonardo Moreno, Jairo Carmona & Juan Rafael Orozco-Arroyave Referencia : NPJ Parkinsons Dis. 2022 Nov 25;8(1):163. DOI (Digital Object Identifier) : 10.1038/s41531-022-00422-8 PMID : 36434017 Derechos de uso : CC BY En línea : https://www.nature.com/articles/s41531-022-00422-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6081 Detecting Parkinson’s disease and its cognitive phenotypes via automated semantic analyses of action stories [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2022.
Obra : NPJ Parkinson's Disease
Idioma : Inglés (eng)
Resumen : Action-concept outcomes are useful targets to identify Parkinson’s disease (PD) patients and differentiate between those with and without mild cognitive impairment (PD-MCI, PD-nMCI). Yet, most approaches employ burdensome examiner-dependent tasks, limiting their utility. We introduce a framework capturing action-concept markers automatically in natural speech. Patients from both subgroups and controls retold an action-laden and a non-action-laden text (AT, nAT). In each retelling, we weighed action and non-action concepts through our automated Proximity-to-Reference-Semantic-Field (P-RSF) metric, for analysis via ANCOVAs (controlling for cognitive dysfunction) and support vector machines. Patients were differentiated from controls based on AT (but not nAT) P-RSF scores. The same occurred in PD-nMCI patients. Conversely, PD-MCI patients exhibited reduced P-RSF scores for both texts. Direct discrimination between patient subgroups was not systematic, but it yielded best outcomes via AT scores. Our approach outperformed classifiers based on corpus-derived embeddings. This framework opens scalable avenues to support PD diagnosis and phenotyping. Mención de responsabilidad : Adolfo M. García, Daniel Escobar-Grisales, Juan Camilo Vásquez Correa, Yamile Bocanegra, Leonardo Moreno, Jairo Carmona & Juan Rafael Orozco-Arroyave Referencia : NPJ Parkinsons Dis. 2022 Nov 25;8(1):163. DOI (Digital Object Identifier) : 10.1038/s41531-022-00422-8 PMID : 36434017 Derechos de uso : CC BY En línea : https://www.nature.com/articles/s41531-022-00422-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6081 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001928 AC-2022-089 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-089Adobe Acrobat PDF Síntomas depresivos, ansiosos e insomnio, y posibles factores asociados en personal de salud, en un Hospital General en Suramérica, durante la pandemia por COVID-19 en 2020 / Camila Valencia Arbeláez ; Carolina Bernal Arbeláez ; Diana Mercedes Ramírez Jiménez ; John Jairo Zuleta Tobón ; Carlos Enrique Yepes Delgado
Título : Síntomas depresivos, ansiosos e insomnio, y posibles factores asociados en personal de salud, en un Hospital General en Suramérica, durante la pandemia por COVID-19 en 2020 Otros títulos : Depressive and anxious symptoms and insomnia, and possible associated factors in health workers, in a General Hospital in South America, during the COVID-19 pandemic in 2020 Tipo de documento : documento electrónico Autores : Camila Valencia Arbeláez, ; Carolina Bernal Arbeláez, ; Diana Mercedes Ramírez Jiménez, ; John Jairo Zuleta Tobón, ; Carlos Enrique Yepes Delgado, Fecha de publicación : 2022 Títulos uniformes : Revista Chilena de Neuro-psiquiatría Idioma : Español (spa) Palabras clave : mental health; COVID-19 pandemic Resumen : Background: pandemic due to novel coronavirus COVID-19 has impacted on the mental health of health care workers all around the world. Material and Methods: this is a cross sectional study in which questionnaires PHQ-9 for depression, GAD-7 for anxiety, ISI-7 for insomnia were virtually and self administered by 876 health care workers laboring in hospital Pablo Tobón Uribe in Medellin city. Results: from 876 participants (29.2% physicians, 21.2% nurses and 49.5% technical nurses), 357 (40.8%) developed depressive symptoms, 300 (34.2%) anxious symptoms and 317 (36.2%) insomnia. Symptoms of depression, anxiety and insomnia were more frequently found in those who did not have basic needs satisfied and in those who felt stigmatized due to being health personal. Besides, depressive symptoms were more frequent in women, anxious symptoms in people younger than 44 years old and insomnia in divorced people. Conclusions: the frequency of mental health problems in health care workers is significant, these findings bring to light the needs for mental health attention in nurses and doctors during COVID-19 pandemic and the research of strategies to mitigate the risk on this population. Feeling stigmatized and not having basic needs satisfied were associated with symptoms of anxiety, depression and insomnia. Mención de responsabilidad : Camila Valencia A., Carolina Bernal A., Diana Mercedes Ramírez J., John Jairo Zuleta T., Carlos Enrique Yepes D. En línea : https://www.sonepsyn.cl/uploads/60-4-7.pdf Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6119 Síntomas depresivos, ansiosos e insomnio, y posibles factores asociados en personal de salud, en un Hospital General en Suramérica, durante la pandemia por COVID-19 en 2020 = Depressive and anxious symptoms and insomnia, and possible associated factors in health workers, in a General Hospital in South America, during the COVID-19 pandemic in 2020 [documento electrónico] / Camila Valencia Arbeláez, ; Carolina Bernal Arbeláez, ; Diana Mercedes Ramírez Jiménez, ; John Jairo Zuleta Tobón, ; Carlos Enrique Yepes Delgado, . - 2022.
Obra : Revista Chilena de Neuro-psiquiatría
Idioma : Español (spa)
Palabras clave : mental health; COVID-19 pandemic Resumen : Background: pandemic due to novel coronavirus COVID-19 has impacted on the mental health of health care workers all around the world. Material and Methods: this is a cross sectional study in which questionnaires PHQ-9 for depression, GAD-7 for anxiety, ISI-7 for insomnia were virtually and self administered by 876 health care workers laboring in hospital Pablo Tobón Uribe in Medellin city. Results: from 876 participants (29.2% physicians, 21.2% nurses and 49.5% technical nurses), 357 (40.8%) developed depressive symptoms, 300 (34.2%) anxious symptoms and 317 (36.2%) insomnia. Symptoms of depression, anxiety and insomnia were more frequently found in those who did not have basic needs satisfied and in those who felt stigmatized due to being health personal. Besides, depressive symptoms were more frequent in women, anxious symptoms in people younger than 44 years old and insomnia in divorced people. Conclusions: the frequency of mental health problems in health care workers is significant, these findings bring to light the needs for mental health attention in nurses and doctors during COVID-19 pandemic and the research of strategies to mitigate the risk on this population. Feeling stigmatized and not having basic needs satisfied were associated with symptoms of anxiety, depression and insomnia. Mención de responsabilidad : Camila Valencia A., Carolina Bernal A., Diana Mercedes Ramírez J., John Jairo Zuleta T., Carlos Enrique Yepes D. En línea : https://www.sonepsyn.cl/uploads/60-4-7.pdf Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6119 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001981 AC-2022-125 Archivo digital Producción Científica Artículos científicos Disponible Global PARITY: study design for a multi-centered, international point prevalence study to estimate the burden of pediatric acute critical illness in resource-limited settings / Eliana López Barón
Título : Global PARITY: study design for a multi-centered, international point prevalence study to estimate the burden of pediatric acute critical illness in resource-limited settings Tipo de documento : documento electrónico Autores : Eliana López Barón, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatric critical illness acute pediatric care critical care outcome low-and lower-middle-income countries resource utilization low resource setting Resumen : Background: The burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, disease presentation, and resource utilization for pediatric populations in RLS, development of a contextual framework for appropriate, evidence-based interventions to guide allocation of limited but available resources is challenging. We present this methods paper which describes our efforts to determine the prevalence, etiology, hospital outcomes, and resource utilization associated with pediatric acute, critical illness in RLS globally. Methods: We will conduct a prospective, observational, multicenter, multinational point prevalence study in sixty-one participating RLS hospitals from North, Central and South America, Africa, Middle East and South Asia with four sampling time points over a 12-month period. Children aged 29 days to 14 years evaluated for acute illness or injury in an emergency department) or directly admitted to an inpatient unit will be enrolled and followed for hospital outcomes and resource utilization for the first seven days of hospitalization. The primary outcome will be prevalence of acute critical illness, which Global PARITY has defined as death within 48 hours of presentation to the hospital, including ED mortality; or admission/transfer to an HDU or ICU; or transfer to another institution for a higher level-of-care; or receiving critical care-level interventions (vasopressor infusion, invasive mechanical ventilation, non-invasive mechanical ventilation) regardless of location in the hospital, among children presenting to the hospital. Secondary outcomes include etiology of critical illness, in-hospital mortality, cause of death, resource utilization, length of hospital stay, and change in neurocognitive status. Data will be managed via REDCap, aggregated, and analyzed across sites. Discussion: This study is expected to address the current gap in understanding of the burden, etiology, resource utilization and outcomes associated with pediatric acute and critical illness in RLS. These data are crucial to inform future research and clinical management decisions and to improve global pediatric hospital outcomes. Mención de responsabilidad : Qalab Abbas, Adrian Holloway, Paula Caporal, Eliana López-Barón, Asya Agulnik, Kenneth E. Remy, John A. Appiah, Jonah Attebery, Ericka L. Fink, Jan Hau Lee, Shubhada Hooli, Niranjan Kissoon, Erika Mille, Srinivas Murthy, Fiona Muttalib, Katie Nielsen, Maria Puerto-Torres, Karla Rodrigues, Firas Sakaan, Adriana Teixeira Rodrigues, Erica A. Tabor, Amelie von Saint Andre-von Arnim, Matthew O. Wiens, William Blackwelder, David He, Teresa B. Kortz and Adnan T. Bhutta on behalf of the PALISI Global Health Subgroup the Global PARITY Investigators Referencia : Front Pediatr. 2022 Jan 28;9:793326. DOI (Digital Object Identifier) : 10.3389/fped.2021.793326 PMID : 35155314 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2021.793326/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6008 Global PARITY: study design for a multi-centered, international point prevalence study to estimate the burden of pediatric acute critical illness in resource-limited settings [documento electrónico] / Eliana López Barón, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatric critical illness acute pediatric care critical care outcome low-and lower-middle-income countries resource utilization low resource setting Resumen : Background: The burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, disease presentation, and resource utilization for pediatric populations in RLS, development of a contextual framework for appropriate, evidence-based interventions to guide allocation of limited but available resources is challenging. We present this methods paper which describes our efforts to determine the prevalence, etiology, hospital outcomes, and resource utilization associated with pediatric acute, critical illness in RLS globally. Methods: We will conduct a prospective, observational, multicenter, multinational point prevalence study in sixty-one participating RLS hospitals from North, Central and South America, Africa, Middle East and South Asia with four sampling time points over a 12-month period. Children aged 29 days to 14 years evaluated for acute illness or injury in an emergency department) or directly admitted to an inpatient unit will be enrolled and followed for hospital outcomes and resource utilization for the first seven days of hospitalization. The primary outcome will be prevalence of acute critical illness, which Global PARITY has defined as death within 48 hours of presentation to the hospital, including ED mortality; or admission/transfer to an HDU or ICU; or transfer to another institution for a higher level-of-care; or receiving critical care-level interventions (vasopressor infusion, invasive mechanical ventilation, non-invasive mechanical ventilation) regardless of location in the hospital, among children presenting to the hospital. Secondary outcomes include etiology of critical illness, in-hospital mortality, cause of death, resource utilization, length of hospital stay, and change in neurocognitive status. Data will be managed via REDCap, aggregated, and analyzed across sites. Discussion: This study is expected to address the current gap in understanding of the burden, etiology, resource utilization and outcomes associated with pediatric acute and critical illness in RLS. These data are crucial to inform future research and clinical management decisions and to improve global pediatric hospital outcomes. Mención de responsabilidad : Qalab Abbas, Adrian Holloway, Paula Caporal, Eliana López-Barón, Asya Agulnik, Kenneth E. Remy, John A. Appiah, Jonah Attebery, Ericka L. Fink, Jan Hau Lee, Shubhada Hooli, Niranjan Kissoon, Erika Mille, Srinivas Murthy, Fiona Muttalib, Katie Nielsen, Maria Puerto-Torres, Karla Rodrigues, Firas Sakaan, Adriana Teixeira Rodrigues, Erica A. Tabor, Amelie von Saint Andre-von Arnim, Matthew O. Wiens, William Blackwelder, David He, Teresa B. Kortz and Adnan T. Bhutta on behalf of the PALISI Global Health Subgroup the Global PARITY Investigators Referencia : Front Pediatr. 2022 Jan 28;9:793326. DOI (Digital Object Identifier) : 10.3389/fped.2021.793326 PMID : 35155314 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2021.793326/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6008 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001843 AC-2022-014 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-014Adobe Acrobat PDF Neglected tropical diseases and sudden cardiac death: The NET-Heart Project / Andrés Felipe Miranda Arboleda
Título : Neglected tropical diseases and sudden cardiac death: The NET-Heart Project Tipo de documento : documento electrónico Autores : Andrés Felipe Miranda Arboleda, Fecha de publicación : 2022 Títulos uniformes : Reviews in Cardiovascular Medicine Idioma : Inglés (eng) Palabras clave : neglected tropical diseases sudden cardiac death myocarditis ventricular arrhythmias Resumen : Sudden cardiac death (SCD) is responsible for approximately 6% of global mortality and 25% of cardiovascular (CV) deaths. SCD has been traditionally linked to coronary artery disease, valvular heart disease, cardiomyopathies, and genetic arrhythmia disorders. However, advancements in care for these diseases have not translated to a proportional reduction in SCD. This suggests an important role of underrecognized contributing pathologies. Neglected tropical diseases (NTDs) are a group of illnesses prevalent in tropical and sub-tropical regions which have been understudied partially due to their high prevalence in marginalized populations. The relationship between SCD and Chagas disease has been well-established, though emerging literature suggests that other NTDs with CV involvement may lead to fatal arrhythmias. Additionally, specific therapies for a subset of NTDs put patients at increased risk of malignant arrhythmias and other cardiac complications. This review aims to summarize the association between a group of selected NTDs and SCD. Mención de responsabilidad : Andrés F. Miranda-Arboleda, Luis Gerardo González-Barrera, Kiera Liblik, Juan Farina, Ezequiel José Zaidel, Clara Saldarriaga, Zier Zhou, Reem Al-Rawi, José Patricio López-López, Jorge P. Juarez-Lloclla, Shyla Gupta, Dorairaj Prabhakaran, R Krishna Kumar, Álvaro Sosa-Liprandi, Adrian Baranchuk DOI (Digital Object Identifier) : 10.31083/j.rcm2307254 Derechos de uso : CC BY En línea : https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307254 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6040 Neglected tropical diseases and sudden cardiac death: The NET-Heart Project [documento electrónico] / Andrés Felipe Miranda Arboleda, . - 2022.
Obra : Reviews in Cardiovascular Medicine
Idioma : Inglés (eng)
Palabras clave : neglected tropical diseases sudden cardiac death myocarditis ventricular arrhythmias Resumen : Sudden cardiac death (SCD) is responsible for approximately 6% of global mortality and 25% of cardiovascular (CV) deaths. SCD has been traditionally linked to coronary artery disease, valvular heart disease, cardiomyopathies, and genetic arrhythmia disorders. However, advancements in care for these diseases have not translated to a proportional reduction in SCD. This suggests an important role of underrecognized contributing pathologies. Neglected tropical diseases (NTDs) are a group of illnesses prevalent in tropical and sub-tropical regions which have been understudied partially due to their high prevalence in marginalized populations. The relationship between SCD and Chagas disease has been well-established, though emerging literature suggests that other NTDs with CV involvement may lead to fatal arrhythmias. Additionally, specific therapies for a subset of NTDs put patients at increased risk of malignant arrhythmias and other cardiac complications. This review aims to summarize the association between a group of selected NTDs and SCD. Mención de responsabilidad : Andrés F. Miranda-Arboleda, Luis Gerardo González-Barrera, Kiera Liblik, Juan Farina, Ezequiel José Zaidel, Clara Saldarriaga, Zier Zhou, Reem Al-Rawi, José Patricio López-López, Jorge P. Juarez-Lloclla, Shyla Gupta, Dorairaj Prabhakaran, R Krishna Kumar, Álvaro Sosa-Liprandi, Adrian Baranchuk DOI (Digital Object Identifier) : 10.31083/j.rcm2307254 Derechos de uso : CC BY En línea : https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307254 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6040 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001882 AC-2022-047 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-047Adobe Acrobat PDF Planteamiento del problema de un proyecto de investigación: escritura y formulación en ciencias de la salud / Jorge Hernando Donado Gómez
Título : Planteamiento del problema de un proyecto de investigación: escritura y formulación en ciencias de la salud Otros títulos : Problem statement in a research project: writing and formulation in the health sciences Tipo de documento : documento electrónico Autores : Jorge Hernando Donado Gómez, Fecha de publicación : 2022 Títulos uniformes : Salud Uninorte Idioma : Español (spa) Palabras clave : epidemiología investigación diseño de investigación pregunta de investigación Resumen : El planteamiento del problema de investigación es el punto de partida de toda investigación científica y es de vital importancia que se realice adecuadamente. Por esta razón, es fundamental tener claro que el desarrollo de un adecuado problema de investigación es un proceso complejo y va a estar compuesto por cinco partes. En primer lugar, se debe definir la condición clínica de interés y tener total claridad sobre ella; se recomienda escribir una pequeña descripción de la enfermedad que sirva como marco de referencia para el problema. Posteriormente, se debe expresar el problema en términos de una situación adversa o negativa (morbilidad, mortalidad, costos, entre otros), bien sea para el paciente, su familia, el sistema de salud o la sociedad. En tercer lugar, el problema de investigación implica que haya un vacío o discrepancia en el conocimiento sobre dicha situación negativa; para identificarlo, es necesario llevar a cabo una revisión sistemática de la literatura con el fin de tener presente las respuestas encontradas en investigaciones previas. Luego, se deben estimar las implicaciones o beneficios prácticos que pueda traer el resolver dicho problema. Finalmente, el problema de investigación se debe concretar de forma justificada y estructurada dando lugar a la pregunta de investigación. Además, el investigador debe estar en la capacidad de determinar si su pregunta de investigación cumple con los elementos necesarios para ser adecuada, las cuales se resumen en la mnemotecnia FINER (factible, interesante, novedosa, ética y relevante). Mención de responsabilidad : Silvia Margarita Vergara-Jaimes, Sara Botero-Bolívar, Jorge Hernando Donado Gómez DOI (Digital Object Identifier) : 10.14482/sun.38.3.610.72 En línea : https://rcientificas.uninorte.edu.co/index.php/salud/article/view/14525 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6072 Planteamiento del problema de un proyecto de investigación: escritura y formulación en ciencias de la salud = Problem statement in a research project: writing and formulation in the health sciences [documento electrónico] / Jorge Hernando Donado Gómez, . - 2022.
Obra : Salud Uninorte
Idioma : Español (spa)
Palabras clave : epidemiología investigación diseño de investigación pregunta de investigación Resumen : El planteamiento del problema de investigación es el punto de partida de toda investigación científica y es de vital importancia que se realice adecuadamente. Por esta razón, es fundamental tener claro que el desarrollo de un adecuado problema de investigación es un proceso complejo y va a estar compuesto por cinco partes. En primer lugar, se debe definir la condición clínica de interés y tener total claridad sobre ella; se recomienda escribir una pequeña descripción de la enfermedad que sirva como marco de referencia para el problema. Posteriormente, se debe expresar el problema en términos de una situación adversa o negativa (morbilidad, mortalidad, costos, entre otros), bien sea para el paciente, su familia, el sistema de salud o la sociedad. En tercer lugar, el problema de investigación implica que haya un vacío o discrepancia en el conocimiento sobre dicha situación negativa; para identificarlo, es necesario llevar a cabo una revisión sistemática de la literatura con el fin de tener presente las respuestas encontradas en investigaciones previas. Luego, se deben estimar las implicaciones o beneficios prácticos que pueda traer el resolver dicho problema. Finalmente, el problema de investigación se debe concretar de forma justificada y estructurada dando lugar a la pregunta de investigación. Además, el investigador debe estar en la capacidad de determinar si su pregunta de investigación cumple con los elementos necesarios para ser adecuada, las cuales se resumen en la mnemotecnia FINER (factible, interesante, novedosa, ética y relevante). Mención de responsabilidad : Silvia Margarita Vergara-Jaimes, Sara Botero-Bolívar, Jorge Hernando Donado Gómez DOI (Digital Object Identifier) : 10.14482/sun.38.3.610.72 En línea : https://rcientificas.uninorte.edu.co/index.php/salud/article/view/14525 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6072 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001916 AC-2022-080 Archivo digital Producción Científica Artículos científicos Disponible The Respiratory Rate-Oxygenation Index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study / Santiago Cardona Marín
Título : The Respiratory Rate-Oxygenation Index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study Tipo de documento : documento electrónico Autores : Santiago Cardona Marín, Fecha de publicación : 2022 Títulos uniformes : Revista Brasileira de Terapia Intensiva Idioma : Inglés (eng) Palabras clave : Cannula Oxygenation Respiratory rate Airway extubation Pneumonia Critical care Intensive care units Resumen : Objective: To investigate the applicability of the Respiratory Rate-Oxygenation Index to identify the risk of high-flow nasal cannula failure in post-extubation pneumonia patients. Methods: This was a 2-year retrospective observational study conducted in a reference hospital in Bogotá, Colombia. All patients in whom post-extubation high-flow nasal cannula therapy was used as a bridge to extubation were included in the study. The Respiratory Rate-Oxygenation Index was calculated to assess the risk of post-extubation high-flow nasal cannula failure. Results: A total of 162 patients were included in the study. Of these, 23.5% developed high-flow nasal cannula failure. The Respiratory Rate-Oxygenation Index was significantly lower in patients who had high-flow nasal cannula failure [median (IQR): 10.0 (7.7 - 14.4) versus 12.6 (10.1 - 15.6); p = 0.006]. Respiratory Rate-Oxygenation Index > 4.88 showed a crude OR of 0.23 (95%CI 0.17 - 0.30) and an adjusted OR of 0.89 (95%CI 0.81 - 0.98) stratified by severity and comorbidity. After logistic regression analysis, the Respiratory Rate-Oxygenation Index had an adjusted OR of 0.90 (95%CI 0.82 - 0.98; p = 0.026). The area under the Receiver Operating Characteristic curve for extubation failure was 0.64 (95%CI 0.53 - 0.75; p = 0.06). The Respiratory Rate-Oxygenation Index did not show differences between patients who survived and those who died during the intensive care unit stay. Conclusion: The Respiratory Rate-Oxygenation Index is an accessible tool to identify patients at risk of failing high-flow nasal cannula post-extubation treatment. Prospective studies are needed to broaden the utility in this scenario. Mención de responsabilidad : Yuli V. Fuentes, Katherine Carvajal, Santiago Cardona, Gina Sofia Montaño, Elsa D. Ibáñez-Prada, Alirio Bastidas, Eder Caceres, Ricardo Buitrago, Marcela Poveda, Luis Felipe Reyes Referencia : Rev Bras Ter Intensiva. 2022 Sep 19;34(3):360-366. DOI (Digital Object Identifier) : 10.5935/0103-507X.20220477-en PMID : 36134847 Derechos de uso : CC BY En línea : http://rbti.org.br/artigo/detalhes/0103507X-34-3-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6104 The Respiratory Rate-Oxygenation Index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study [documento electrónico] / Santiago Cardona Marín, . - 2022.
Obra : Revista Brasileira de Terapia Intensiva
Idioma : Inglés (eng)
Palabras clave : Cannula Oxygenation Respiratory rate Airway extubation Pneumonia Critical care Intensive care units Resumen : Objective: To investigate the applicability of the Respiratory Rate-Oxygenation Index to identify the risk of high-flow nasal cannula failure in post-extubation pneumonia patients. Methods: This was a 2-year retrospective observational study conducted in a reference hospital in Bogotá, Colombia. All patients in whom post-extubation high-flow nasal cannula therapy was used as a bridge to extubation were included in the study. The Respiratory Rate-Oxygenation Index was calculated to assess the risk of post-extubation high-flow nasal cannula failure. Results: A total of 162 patients were included in the study. Of these, 23.5% developed high-flow nasal cannula failure. The Respiratory Rate-Oxygenation Index was significantly lower in patients who had high-flow nasal cannula failure [median (IQR): 10.0 (7.7 - 14.4) versus 12.6 (10.1 - 15.6); p = 0.006]. Respiratory Rate-Oxygenation Index > 4.88 showed a crude OR of 0.23 (95%CI 0.17 - 0.30) and an adjusted OR of 0.89 (95%CI 0.81 - 0.98) stratified by severity and comorbidity. After logistic regression analysis, the Respiratory Rate-Oxygenation Index had an adjusted OR of 0.90 (95%CI 0.82 - 0.98; p = 0.026). The area under the Receiver Operating Characteristic curve for extubation failure was 0.64 (95%CI 0.53 - 0.75; p = 0.06). The Respiratory Rate-Oxygenation Index did not show differences between patients who survived and those who died during the intensive care unit stay. Conclusion: The Respiratory Rate-Oxygenation Index is an accessible tool to identify patients at risk of failing high-flow nasal cannula post-extubation treatment. Prospective studies are needed to broaden the utility in this scenario. Mención de responsabilidad : Yuli V. Fuentes, Katherine Carvajal, Santiago Cardona, Gina Sofia Montaño, Elsa D. Ibáñez-Prada, Alirio Bastidas, Eder Caceres, Ricardo Buitrago, Marcela Poveda, Luis Felipe Reyes Referencia : Rev Bras Ter Intensiva. 2022 Sep 19;34(3):360-366. DOI (Digital Object Identifier) : 10.5935/0103-507X.20220477-en PMID : 36134847 Derechos de uso : CC BY En línea : http://rbti.org.br/artigo/detalhes/0103507X-34-3-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6104 Reserva
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AC-2022-113Adobe Acrobat PDF
Título : Primary non-gestational choriocarcinoma of the uterine cervix Tipo de documento : documento electrónico Autores : Gabriel Jaime Varela Aguirre, Fecha de publicación : 2022 Títulos uniformes : International Journal of Gynecological Cancer Idioma : Inglés (eng) Palabras clave : cervix uteri gynecology pathology trophoblastic neoplasms Mención de responsabilidad : Camilo Andrés Pérez Montiel, Gabriel Jaime Varela Aguirre Referencia : Int J Gynecol Cancer. 2022 Jan;32(1):111-112. DOI (Digital Object Identifier) : 10.1136/ijgc-2021-003061 PMID : 34980664 En línea : https://ijgc.bmj.com/content/32/1/111.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5999 Primary non-gestational choriocarcinoma of the uterine cervix [documento electrónico] / Gabriel Jaime Varela Aguirre, . - 2022.
Obra : International Journal of Gynecological Cancer
Idioma : Inglés (eng)
Palabras clave : cervix uteri gynecology pathology trophoblastic neoplasms Mención de responsabilidad : Camilo Andrés Pérez Montiel, Gabriel Jaime Varela Aguirre Referencia : Int J Gynecol Cancer. 2022 Jan;32(1):111-112. DOI (Digital Object Identifier) : 10.1136/ijgc-2021-003061 PMID : 34980664 En línea : https://ijgc.bmj.com/content/32/1/111.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5999 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001980 AC-2022-005 Archivo digital Producción Científica Artículos científicos Disponible Ataxia with ocular apraxia type 1 (AOA1) (APTX, W279* Mutation): neurological, neuropsychological, and molecular outlining of a heterogenous phenotype in four Colombian Siblings / Dora Lilia Hernández López
Título : Ataxia with ocular apraxia type 1 (AOA1) (APTX, W279* Mutation): neurological, neuropsychological, and molecular outlining of a heterogenous phenotype in four Colombian Siblings Tipo de documento : documento electrónico Autores : Dora Lilia Hernández López, Fecha de publicación : 2022 Títulos uniformes : Molecular Neurobiology Idioma : Inglés (eng) Palabras clave : AOA1 APTX Ataxia with ocular apraxia type 1 C2H2-type zinc fingers Colombia Latino population W279* mutation Resumen : Hereditary ataxias are a group of devastating neurological disorders that affect coordination of gait and are often associated with poor coordination of hands, speech, and eye movements. Ataxia with ocular apraxia type 1 (AOA1) (OMIM: 606,350.0006) is characterized by slowly progressive symptoms of childhood-onset and pathogenic mutations in APTX; the only known cause underpinning AOA1. APTX encodes the protein aprataxin, composed of three domains sharing homology with proteins involved in DNA damage, signaling, and repair. We present four siblings from an endogamic family in a rural, isolated town of Colombia with ataxia and ocular apraxia of childhood-onset and confirmed molecular diagnosis of AOA1, homozygous for the W279* p.Trp279Ter mutation. We predicted the mutated APTX with AlphaFold to demonstrate the effects of this stop-gain mutation that deletes three beta helices encoded by amino acid 270 to 339 rescinding the C2H2-type zinc fingers (Znf) (C2H2 Znf) DNA-binding, the DNA-repair domain, and the whole 3D structure of APTX. All siblings exhibited different ages of onset (4, 6, 8, and 11 years old) and heterogeneous patterns of dysarthria (ranging from absence to mild-moderate dysarthria). Neuropsychological evaluation showed no neurocognitive impairment in three siblings, but one sibling showed temporospatial disorientation, semantic and phonologic fluency impairment, episodic memory affection, constructional apraxia, moderate anomia, low executive function, and symptoms of depression. To our knowledge, this report represents the most extensive series of siblings affected with AOA1 in Latin America, and the genetic analysis completed adds important knowledge to outline this family's disease and general complex phenotype of hereditary ataxias. Mención de responsabilidad : David Aguillon, Daniel Vasquez, Lucia Madrigal, Sonia Moreno, Dora Hernández, Mario Isaza-Ruget, Juan Javier Lopez, Iván Landires, Virginia Nuñez-Samudio, Carlos M. Restrepo, Oscar M. Vidal, Jorge I. Vélez, Mauricio Arcos-Holzinger, Francisco Lopera & Mauricio Arcos-Burgos Referencia : Mol Neurobiol. 2022 Jun;59(6):3845-3858. DOI (Digital Object Identifier) : 10.1007/s12035-022-02821-7 PMID : 35420381 En línea : https://link.springer.com/article/10.1007/s12035-022-02821-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6031 Ataxia with ocular apraxia type 1 (AOA1) (APTX, W279* Mutation): neurological, neuropsychological, and molecular outlining of a heterogenous phenotype in four Colombian Siblings [documento electrónico] / Dora Lilia Hernández López, . - 2022.
Obra : Molecular Neurobiology
Idioma : Inglés (eng)
Palabras clave : AOA1 APTX Ataxia with ocular apraxia type 1 C2H2-type zinc fingers Colombia Latino population W279* mutation Resumen : Hereditary ataxias are a group of devastating neurological disorders that affect coordination of gait and are often associated with poor coordination of hands, speech, and eye movements. Ataxia with ocular apraxia type 1 (AOA1) (OMIM: 606,350.0006) is characterized by slowly progressive symptoms of childhood-onset and pathogenic mutations in APTX; the only known cause underpinning AOA1. APTX encodes the protein aprataxin, composed of three domains sharing homology with proteins involved in DNA damage, signaling, and repair. We present four siblings from an endogamic family in a rural, isolated town of Colombia with ataxia and ocular apraxia of childhood-onset and confirmed molecular diagnosis of AOA1, homozygous for the W279* p.Trp279Ter mutation. We predicted the mutated APTX with AlphaFold to demonstrate the effects of this stop-gain mutation that deletes three beta helices encoded by amino acid 270 to 339 rescinding the C2H2-type zinc fingers (Znf) (C2H2 Znf) DNA-binding, the DNA-repair domain, and the whole 3D structure of APTX. All siblings exhibited different ages of onset (4, 6, 8, and 11 years old) and heterogeneous patterns of dysarthria (ranging from absence to mild-moderate dysarthria). Neuropsychological evaluation showed no neurocognitive impairment in three siblings, but one sibling showed temporospatial disorientation, semantic and phonologic fluency impairment, episodic memory affection, constructional apraxia, moderate anomia, low executive function, and symptoms of depression. To our knowledge, this report represents the most extensive series of siblings affected with AOA1 in Latin America, and the genetic analysis completed adds important knowledge to outline this family's disease and general complex phenotype of hereditary ataxias. Mención de responsabilidad : David Aguillon, Daniel Vasquez, Lucia Madrigal, Sonia Moreno, Dora Hernández, Mario Isaza-Ruget, Juan Javier Lopez, Iván Landires, Virginia Nuñez-Samudio, Carlos M. Restrepo, Oscar M. Vidal, Jorge I. Vélez, Mauricio Arcos-Holzinger, Francisco Lopera & Mauricio Arcos-Burgos Referencia : Mol Neurobiol. 2022 Jun;59(6):3845-3858. DOI (Digital Object Identifier) : 10.1007/s12035-022-02821-7 PMID : 35420381 En línea : https://link.springer.com/article/10.1007/s12035-022-02821-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6031 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001872 AC-2022-037 Archivo digital Producción Científica Artículos científicos Disponible Lente multifocal de tres piezas con captura de la óptica, como manejo de ruptura de la cápsula posterior en paciente sometida a cirugía facorrefractiva / Yeliana Mailyn Valencia Gómez
Título : Lente multifocal de tres piezas con captura de la óptica, como manejo de ruptura de la cápsula posterior en paciente sometida a cirugía facorrefractiva Otros títulos : Three-piece multifocal intraocular lens with optic capture as management of posterior capsule rupture in a patient undergoing refractive lens exchange Tipo de documento : documento electrónico Autores : Yeliana Mailyn Valencia Gómez, Fecha de publicación : 2022 Títulos uniformes : Revista de la Sociedad Colombiana de Oftalmología Idioma : Español (spa) Palabras clave : Lentes intraoculares multifocales Cápsula posterior Ruptura Resumen : Se presenta el caso de una paciente sometida a cirugía facorrefractiva que sufre una ruptura de la cápsula posterior en la cirugía del primer ojo. Ante la imposibilidad de usar un lente trifocal de una pieza como inicialmente se tenía planteado, se realiza implante de lente multifocal de tres piezas en el sulcus con captura pupilar. Se reportan las imágenes de Scheimpflug y de retroiluminación del lente de tres piezas de un ojo y el lente de una pieza del ojo contralateral. Mención de responsabilidad : Kepa Balparda, Yeliana M. Valencia-Gómez, Ma. Alejandra Nicholls-Molina y Tatiana Herrera-Chalarca DOI (Digital Object Identifier) : 10.24875/RSCO.22000024 Derechos de uso : CC BY-NC-ND En línea : https://www.revistasco.com/frame_esp.php?id=44 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6063 Lente multifocal de tres piezas con captura de la óptica, como manejo de ruptura de la cápsula posterior en paciente sometida a cirugía facorrefractiva = Three-piece multifocal intraocular lens with optic capture as management of posterior capsule rupture in a patient undergoing refractive lens exchange [documento electrónico] / Yeliana Mailyn Valencia Gómez, . - 2022.
Obra : Revista de la Sociedad Colombiana de Oftalmología
Idioma : Español (spa)
Palabras clave : Lentes intraoculares multifocales Cápsula posterior Ruptura Resumen : Se presenta el caso de una paciente sometida a cirugía facorrefractiva que sufre una ruptura de la cápsula posterior en la cirugía del primer ojo. Ante la imposibilidad de usar un lente trifocal de una pieza como inicialmente se tenía planteado, se realiza implante de lente multifocal de tres piezas en el sulcus con captura pupilar. Se reportan las imágenes de Scheimpflug y de retroiluminación del lente de tres piezas de un ojo y el lente de una pieza del ojo contralateral. Mención de responsabilidad : Kepa Balparda, Yeliana M. Valencia-Gómez, Ma. Alejandra Nicholls-Molina y Tatiana Herrera-Chalarca DOI (Digital Object Identifier) : 10.24875/RSCO.22000024 Derechos de uso : CC BY-NC-ND En línea : https://www.revistasco.com/frame_esp.php?id=44 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6063 Reserva
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AC-2022-071Adobe Acrobat PDF R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation / Sergio Iván Hoyos Duque
Título : R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, Fecha de publicación : 2022 Títulos uniformes : JHEP Reports Idioma : Inglés (eng) Resumen : Background & aims: Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management. Methods: Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085). Results: In the TC, 76.4% of patients with HCC met the Milan criteria, and 89.9% had an AFP score of ≤2 points. The recurrence risk reassessment (R3)-AFP model was designed based on variables independently associated with recurrence in the TC (with associated weights): ≥4 nodules (sub-distribution of hazard ratio [SHR] = 1.88, 1 point), size of largest nodule (3-6 cm: SHR = 1.83, 1 point; >6 cm: SHR = 5.82, 5 points), presence of microvascular invasion (MVI; SHR = 2.69, 2 points), nuclear grade >II (SHR = 1.20, 1 point), and last pre-LT AFP value (101-1,000 ng/ml: SHR = 1.57, 1 point; >1,000 ng/ml: SHR = 2.83, 2 points). Wolber's c-index was 0.76 (95% CI 0.72-0.80), significantly superior to an R3 model without AFP (0.75; 95% CI 0.72-0.79; p = 0.01). Four 5-year recurrence risk categories were identified: very low (score = 0; 5.5%), low (1-2 points; 15.1%), high (3-6 points; 39.1%), and very high (>6 points; 73.9%). The R3-AFP score performed well in the VC (Wolber's c-index of 0.78; 95% CI 0.73-0.83). Conclusions: The R3 score including the last pre-LT AFP value (R3-AFP score) provides a user-friendly, standardised framework to design post-LT surveillance strategies, protocols, or adjuvant therapy trials for HCC not limited to the Milan criteria. Mención de responsabilidad : Charlotte Costentin, Federico Piñero, Helena Degroote, Andrea Notarpaolo, Ilka F. Boin, Karim Boudjema, Cinzia Baccaro, Luis G. Podestá, Philippe Bachellier, Giuseppe Maria Ettorre, Jaime Poniachik, Fabrice Muscari, Fabrizio Dibenedetto, Sergio Hoyos Duque, Ephrem Salame, Umberto Cillo, Sebastian Marciano, Claire Vanlemmens, Stefano Fagiuoli, Patrizia Burra, Hans Van Vlierberghe, Daniel Cherqui, Quirino Lai, Marcelo Silva, Fernando Rubinstein, Christophe Duvoux Referencia : JHEP Rep. 2022 Feb 2;4(5):100445. DOI (Digital Object Identifier) : 10.1016/j.jhepr.2022.100445 PMID : 35360522 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2589555922000179 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6095 R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation [documento electrónico] / Sergio Iván Hoyos Duque, . - 2022.
Obra : JHEP Reports
Idioma : Inglés (eng)
Resumen : Background & aims: Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management. Methods: Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085). Results: In the TC, 76.4% of patients with HCC met the Milan criteria, and 89.9% had an AFP score of ≤2 points. The recurrence risk reassessment (R3)-AFP model was designed based on variables independently associated with recurrence in the TC (with associated weights): ≥4 nodules (sub-distribution of hazard ratio [SHR] = 1.88, 1 point), size of largest nodule (3-6 cm: SHR = 1.83, 1 point; >6 cm: SHR = 5.82, 5 points), presence of microvascular invasion (MVI; SHR = 2.69, 2 points), nuclear grade >II (SHR = 1.20, 1 point), and last pre-LT AFP value (101-1,000 ng/ml: SHR = 1.57, 1 point; >1,000 ng/ml: SHR = 2.83, 2 points). Wolber's c-index was 0.76 (95% CI 0.72-0.80), significantly superior to an R3 model without AFP (0.75; 95% CI 0.72-0.79; p = 0.01). Four 5-year recurrence risk categories were identified: very low (score = 0; 5.5%), low (1-2 points; 15.1%), high (3-6 points; 39.1%), and very high (>6 points; 73.9%). The R3-AFP score performed well in the VC (Wolber's c-index of 0.78; 95% CI 0.73-0.83). Conclusions: The R3 score including the last pre-LT AFP value (R3-AFP score) provides a user-friendly, standardised framework to design post-LT surveillance strategies, protocols, or adjuvant therapy trials for HCC not limited to the Milan criteria. Mención de responsabilidad : Charlotte Costentin, Federico Piñero, Helena Degroote, Andrea Notarpaolo, Ilka F. Boin, Karim Boudjema, Cinzia Baccaro, Luis G. Podestá, Philippe Bachellier, Giuseppe Maria Ettorre, Jaime Poniachik, Fabrice Muscari, Fabrizio Dibenedetto, Sergio Hoyos Duque, Ephrem Salame, Umberto Cillo, Sebastian Marciano, Claire Vanlemmens, Stefano Fagiuoli, Patrizia Burra, Hans Van Vlierberghe, Daniel Cherqui, Quirino Lai, Marcelo Silva, Fernando Rubinstein, Christophe Duvoux Referencia : JHEP Rep. 2022 Feb 2;4(5):100445. DOI (Digital Object Identifier) : 10.1016/j.jhepr.2022.100445 PMID : 35360522 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2589555922000179 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6095 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001943 AC-2022-104 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-104Adobe Acrobat PDF Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America / Alejandro Díaz Díaz ; Mónica Rosa Trujillo Honeysberg
Título : Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6022 Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America [documento electrónico] / Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6022 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001862 AC-2022-028 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-028Adobe Acrobat PDF El índice de fragilidad y sus características en ensayos clínicos aleatorizados de diabetes mellitus / Jorge Hernando Donado Gómez
Título : El índice de fragilidad y sus características en ensayos clínicos aleatorizados de diabetes mellitus Otros títulos : The Fragility Index and its characteristics in randomized clinical trials of diabetes mellitus Tipo de documento : documento electrónico Autores : Jorge Hernando Donado Gómez, Fecha de publicación : 2022 Títulos uniformes : CES Medicina Idioma : Español (spa) Palabras clave : índice de fragilidad diabetes mellitus ensayos clínicos controlados Resumen : Introducción: para valorar la robustez de los resultados se ha propuesto una herramienta llamada el Índice de Fragilidad (IF), esta se define como el mínimo número de pacientes que se tienen que cambiar de “No eventos” a “Eventos” en el grupo de intervención para que un resultado estadísticamente significativo pase a no significativo, evidenciando que entre menor sea el IF, los resultados serán más frágiles. Diferentes autores han encontrado que la significancia de los resultados de muchos Ensayos Clínicos Controlados (ECA) dependen de pocos eventos. El objetivo del estudio fue evaluar el IF de los ECA en diabetes mellitus de cinco de las revistas médicas de mayor impacto a nivel mundial. Metodología: se realizó búsqueda electrónica en PubMed, para identificar ECA en Annals of Internal Medicine, BMJ, The Lancet, The New England Journal of Medicine y JAMA. Se revisaron los ECA en pacientes con diabetes mellitus o prediabetes y se calculó el IF para cada desenlace según el método descrito por Walsh et al, usando tablas de contingencia 2x2. Se planeó usar el coeficiente de correlación de Spearman para evaluar la correlación entre el IF y el tamaño de la muestra, el número de eventos, el valor de p y el tiempo de seguimiento. Se evaluó la significancia de todos los resultados con un valor de p Mención de responsabilidad : David Benavides-Zora, Sara Vásquez-Martínez, Jorge Hernando Donado Gómez Referencia : CES med ; 36(2): 106-121, mayo-ago. 2022. DOI (Digital Object Identifier) : 10.21615/cesmedicina.6632 Derechos de uso : CC BY-NC-SA En línea : https://revistas.ces.edu.co/index.php/medicina/article/view/6632 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6054 El índice de fragilidad y sus características en ensayos clínicos aleatorizados de diabetes mellitus = The Fragility Index and its characteristics in randomized clinical trials of diabetes mellitus [documento electrónico] / Jorge Hernando Donado Gómez, . - 2022.
Obra : CES Medicina
Idioma : Español (spa)
Palabras clave : índice de fragilidad diabetes mellitus ensayos clínicos controlados Resumen : Introducción: para valorar la robustez de los resultados se ha propuesto una herramienta llamada el Índice de Fragilidad (IF), esta se define como el mínimo número de pacientes que se tienen que cambiar de “No eventos” a “Eventos” en el grupo de intervención para que un resultado estadísticamente significativo pase a no significativo, evidenciando que entre menor sea el IF, los resultados serán más frágiles. Diferentes autores han encontrado que la significancia de los resultados de muchos Ensayos Clínicos Controlados (ECA) dependen de pocos eventos. El objetivo del estudio fue evaluar el IF de los ECA en diabetes mellitus de cinco de las revistas médicas de mayor impacto a nivel mundial. Metodología: se realizó búsqueda electrónica en PubMed, para identificar ECA en Annals of Internal Medicine, BMJ, The Lancet, The New England Journal of Medicine y JAMA. Se revisaron los ECA en pacientes con diabetes mellitus o prediabetes y se calculó el IF para cada desenlace según el método descrito por Walsh et al, usando tablas de contingencia 2x2. Se planeó usar el coeficiente de correlación de Spearman para evaluar la correlación entre el IF y el tamaño de la muestra, el número de eventos, el valor de p y el tiempo de seguimiento. Se evaluó la significancia de todos los resultados con un valor de p Mención de responsabilidad : David Benavides-Zora, Sara Vásquez-Martínez, Jorge Hernando Donado Gómez Referencia : CES med ; 36(2): 106-121, mayo-ago. 2022. DOI (Digital Object Identifier) : 10.21615/cesmedicina.6632 Derechos de uso : CC BY-NC-SA En línea : https://revistas.ces.edu.co/index.php/medicina/article/view/6632 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6054 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001898 AC-2022-062 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-062Adobe Acrobat PDF Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country / Mónica Rosa Trujillo Honeysberg
Título : Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Encephalitis risk factors PICU etiology children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Palabras clave : Encephalitis risk factors PICU etiology children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001933 AC-2022-094 Archivo digital Producción Científica Artículos científicos Disponible Direct oral anticoagulants for the treatment of cancer-associated venous thromboembolism: a Latin American perspective / Kenny Mauricio Gálvez Cárdenas
Título : Direct oral anticoagulants for the treatment of cancer-associated venous thromboembolism: a Latin American perspective Tipo de documento : documento electrónico Autores : Kenny Mauricio Gálvez Cárdenas, Fecha de publicación : 2022 Títulos uniformes : Clinical and Applied Thrombosis/Hemostasis Idioma : Inglés (eng) Palabras clave : anticoagulation cancer venous thromboembolism Resumen : Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in patients with cancer. On the basis of results from randomized controlled trials, direct oral anticoagulants (DOACs) are now recommended for the treatment of cancer-associated VTE. The decision to use a DOAC requires consideration of bleeding risk, particularly in patients with gastrointestinal (GI) malignancies, the cost-benefit and convenience of oral therapy, and patient preference. While efficacy with apixaban, edoxaban, and rivaroxaban versus dalteparin has been consistent in the treatment of cancer-associated VTE, heterogeneity is evident with respect to major GI bleeding, with an increased risk with edoxaban and rivaroxaban but not apixaban. Although cost and accessibility vary in different countries of Latin America, DOACs should be considered for the long-term treatment of cancer-associated VTE in all patients who are likely to benefit. Apixaban may be the preferred DOAC in patients with GI malignancies and LMWH may be preferred for patients with upper or unresected lower GI tumors. Vitamin K antagonists should only be used for anticoagulation when DOACs and low molecular weight heparin are inaccessible or unsuitable. Mención de responsabilidad : Rodrigo Abensur Athanazio, José Manuel Ceresetto, Luis Javier Marfil Rivera, Gabriela Cesarman-Maus, Kenny Galvez, Marcos Arêas Marques, Aldo Hugo Tabares, Carlos Alberto Ortiz Santacruz, Fernando Costa Santini, Luis Corrales, Alexander T Cohen Referencia : Clin Appl Thromb Hemost. Jan-Dec 2022;28:10760296221082988. DOI (Digital Object Identifier) : 10.1177/10760296221082988 PMID : 35261295 Derechos de uso : CC BY-NC En línea : https://journals.sagepub.com/doi/10.1177/10760296221082988 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6013 Direct oral anticoagulants for the treatment of cancer-associated venous thromboembolism: a Latin American perspective [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, . - 2022.
Obra : Clinical and Applied Thrombosis/Hemostasis
Idioma : Inglés (eng)
Palabras clave : anticoagulation cancer venous thromboembolism Resumen : Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in patients with cancer. On the basis of results from randomized controlled trials, direct oral anticoagulants (DOACs) are now recommended for the treatment of cancer-associated VTE. The decision to use a DOAC requires consideration of bleeding risk, particularly in patients with gastrointestinal (GI) malignancies, the cost-benefit and convenience of oral therapy, and patient preference. While efficacy with apixaban, edoxaban, and rivaroxaban versus dalteparin has been consistent in the treatment of cancer-associated VTE, heterogeneity is evident with respect to major GI bleeding, with an increased risk with edoxaban and rivaroxaban but not apixaban. Although cost and accessibility vary in different countries of Latin America, DOACs should be considered for the long-term treatment of cancer-associated VTE in all patients who are likely to benefit. Apixaban may be the preferred DOAC in patients with GI malignancies and LMWH may be preferred for patients with upper or unresected lower GI tumors. Vitamin K antagonists should only be used for anticoagulation when DOACs and low molecular weight heparin are inaccessible or unsuitable. Mención de responsabilidad : Rodrigo Abensur Athanazio, José Manuel Ceresetto, Luis Javier Marfil Rivera, Gabriela Cesarman-Maus, Kenny Galvez, Marcos Arêas Marques, Aldo Hugo Tabares, Carlos Alberto Ortiz Santacruz, Fernando Costa Santini, Luis Corrales, Alexander T Cohen Referencia : Clin Appl Thromb Hemost. Jan-Dec 2022;28:10760296221082988. DOI (Digital Object Identifier) : 10.1177/10760296221082988 PMID : 35261295 Derechos de uso : CC BY-NC En línea : https://journals.sagepub.com/doi/10.1177/10760296221082988 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6013 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001850 AC-2022-019 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-019Adobe Acrobat PDF