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Human Pathology
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Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: morphological findings / Luis Vicente Syro Moreno
Título : Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: morphological findings Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2007 Títulos uniformes : Human Pathology Idioma : Inglés (eng) Palabras clave : Pathology Pituitary Pituitary neoplasms Prolactin Temozolomid Resumen : Administration of temozolomide to a 46-year-old man with an invasive aggressive prolactin (PRL)–secreting pituitary neoplasm resulted in improvement of the clinical condition and significant decrease of blood PRL levels. Histologic, immunohistochemical, and electron microscopic study demonstrated marked morphological differences in the tumor exposed to temozolomide compared with the unexposed tumor. Necrosis, hemorrhagic areas, accumulation of connective tissue, focal inflammatory infiltration, and neuronal transformation were seen. Immunohistochemical prognostic indicators showed a reduction in growth potential. Based on the clinical, laboratory, and morphological findings, we recommend temozolomide therapy in patients with pituitary tumors not responding adequately to other treatment options. Mención de responsabilidad : Kalman Kovacs, Eva Horvath, Luis V Syro, Humberto Uribe, Luis C Penagos, Leon D Ortiz, Camilo E Fadul Referencia : Hum Pathol. 2007 Jan;38(1):185-9. DOI (Digital Object Identifier) : 10.1016/j.humpath.2006.07.014 PMID : 17056093 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0046817706004886 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4424 Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: morphological findings [documento electrónico] / Luis Vicente Syro Moreno, . - 2007.
Obra : Human Pathology
Idioma : Inglés (eng)
Palabras clave : Pathology Pituitary Pituitary neoplasms Prolactin Temozolomid Resumen : Administration of temozolomide to a 46-year-old man with an invasive aggressive prolactin (PRL)–secreting pituitary neoplasm resulted in improvement of the clinical condition and significant decrease of blood PRL levels. Histologic, immunohistochemical, and electron microscopic study demonstrated marked morphological differences in the tumor exposed to temozolomide compared with the unexposed tumor. Necrosis, hemorrhagic areas, accumulation of connective tissue, focal inflammatory infiltration, and neuronal transformation were seen. Immunohistochemical prognostic indicators showed a reduction in growth potential. Based on the clinical, laboratory, and morphological findings, we recommend temozolomide therapy in patients with pituitary tumors not responding adequately to other treatment options. Mención de responsabilidad : Kalman Kovacs, Eva Horvath, Luis V Syro, Humberto Uribe, Luis C Penagos, Leon D Ortiz, Camilo E Fadul Referencia : Hum Pathol. 2007 Jan;38(1):185-9. DOI (Digital Object Identifier) : 10.1016/j.humpath.2006.07.014 PMID : 17056093 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0046817706004886 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4424 Reserva
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