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Infection and Immunity
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Autre
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Documentos disponibles con este título uniforme (4)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaInhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin / Luz Elena Cano Restrepo ; Beatriz Gómez ; Ángela Restrepo Moreno
Título : Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1994 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells. Mención de responsabilidad : L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens Referencia : Infect Immun. 1994 Apr;62(4):1494-5. PMID : 8132359 En línea : https://iai.asm.org/content/62/4/1494 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375 Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin [documento electrónico] / Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno, . - 1994.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells. Mención de responsabilidad : L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens Referencia : Infect Immun. 1994 Apr;62(4):1494-5. PMID : 8132359 En línea : https://iai.asm.org/content/62/4/1494 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000875 AC-1994-002 Archivo digital Producción Científica Artículos científicos Disponible
Título : Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice significantly inhibited transformation of ingested conidia. Mención de responsabilidad : L E Cano, E Brummer, D A Stevens, A Restrepo Referencia : Infect Immun. 1992 May;60(5):2096-100. PMID : 1563800 En línea : https://iai.asm.org/content/60/5/2096.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4363 Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages [documento electrónico] / Luz Elena Cano Restrepo, ; Ángela Restrepo Moreno, . - 1992.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice significantly inhibited transformation of ingested conidia. Mención de responsabilidad : L E Cano, E Brummer, D A Stevens, A Restrepo Referencia : Infect Immun. 1992 May;60(5):2096-100. PMID : 1563800 En línea : https://iai.asm.org/content/60/5/2096.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4363 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000863 AC-1992-002 Archivo digital Producción Científica Artículos científicos Disponible
Título : Inhibition by estrogens of conidium-to-yeast conversion in the fungus Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Maria E. Salazar, ; Ángela Restrepo Moreno, Fecha de publicación : 1988 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Conidia produced by Paracoccidioides brasiliensis are inhibited by mammalian estrogens in their in vitro conversion into yeast-form cells. This was demonstrated with four different isolates. In these experiments, conversion was reduced to 10.7 and 34.4% of the control values by 17-beta-estradiol at 10(-6) and 10(-8) M, respectively. At the same concentrations, the synthetic estrogen diethylstilbestrol was slightly less inhibitory. In contrast, other sex hormones and analogs, i.e., testosterone, 17-alpha-estradiol, tamoxifen, and hydroxytamoxifen, had no effect on conidium-to-yeast conversion. Previous studies have shown that estrogens similarly inhibit mycelium-to-yeast-form transition in P. brasiliensis. Conidia, and not mycelial fragments, are believed to be the natural infectious propagules. These findings with conidia support the hypothesis that estrogens, affecting the initial host-parasite interactions by suppressing conversion to the parasitic form of the organism, are, at least in part, responsible for the greater resistance of females to paracoccidioidomycosis. Mención de responsabilidad : M E Salazar, A Restrepo, D A Stevens Referencia : Infect Immun. 1988 Mar;56(3):711-3 PMID : 3343055 En línea : https://iai.asm.org/content/56/3/711.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4346 Inhibition by estrogens of conidium-to-yeast conversion in the fungus Paracoccidioides brasiliensis [documento electrónico] / Maria E. Salazar, ; Ángela Restrepo Moreno, . - 1988.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Conidia produced by Paracoccidioides brasiliensis are inhibited by mammalian estrogens in their in vitro conversion into yeast-form cells. This was demonstrated with four different isolates. In these experiments, conversion was reduced to 10.7 and 34.4% of the control values by 17-beta-estradiol at 10(-6) and 10(-8) M, respectively. At the same concentrations, the synthetic estrogen diethylstilbestrol was slightly less inhibitory. In contrast, other sex hormones and analogs, i.e., testosterone, 17-alpha-estradiol, tamoxifen, and hydroxytamoxifen, had no effect on conidium-to-yeast conversion. Previous studies have shown that estrogens similarly inhibit mycelium-to-yeast-form transition in P. brasiliensis. Conidia, and not mycelial fragments, are believed to be the natural infectious propagules. These findings with conidia support the hypothesis that estrogens, affecting the initial host-parasite interactions by suppressing conversion to the parasitic form of the organism, are, at least in part, responsible for the greater resistance of females to paracoccidioidomycosis. Mención de responsabilidad : M E Salazar, A Restrepo, D A Stevens Referencia : Infect Immun. 1988 Mar;56(3):711-3 PMID : 3343055 En línea : https://iai.asm.org/content/56/3/711.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4346 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000847 AC-1988-002 Archivo digital Producción Científica Artículos científicos Disponible
Título : Estrogens inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: Implications for resistance of females to Paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Maria E. Salazar, ; Luz Elena Cano Restrepo, Fecha de publicación : 1984 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Evidence that disease due to the thermally dimorphic fungus Paracoccidioides brasiliensis occurs post-puberty predominantly in males led us to hypothesize that hormonal factors critically affect its pathogenesis. We show here that estrogens inhibit mycelial- to yeast-form transformation of P. brasiliensis in vitro. Transformation of three isolates was inhibited to 71, 33, and 19% of the control values in the presence of 10(-10), 10(-8), and 10(-6) M 17 beta-estradiol, respectively. The synthetic estrogen diethylstilbestrol was active but less potent than estradiol, whereas testosterone, 17 alpha-estradiol, tamoxifen, and corticosterone were inactive. This function was specifically inhibited, since yeast-to-mycelium transformation, yeast growth, and yeast reproduction by budding were unaffected by 17 beta-estradiol. Of note is the fact that mycelium-to-yeast transformation occurs as the first step in vivo in the establishment of infection. The cytosol of the three isolates studied possesses a steroid-binding protein which has high affinity for 17 beta-estradiol. We believe that this binding protein represents a P. brasiliensis hormone receptor which can also recognize mammalian estrogens. We hypothesize that the ability of estrogen to decrease or delay mycelium-to-yeast transformation at the initial site of infection contributes to or is responsible for the marked resistance of females, and that the binder described is the molecular site of action. Mención de responsabilidad : A Restrepo, M E Salazar, L E Cano, E P Stover, D Feldman, D A Stevens Referencia : Infect Immun. 1984 Nov;46(2):346-53. PMID : 6500694 En línea : https://iai.asm.org/content/46/2/346.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4327 Estrogens inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: Implications for resistance of females to Paracoccidioidomycosis [documento electrónico] / Ángela Restrepo Moreno, ; Maria E. Salazar, ; Luz Elena Cano Restrepo, . - 1984.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Evidence that disease due to the thermally dimorphic fungus Paracoccidioides brasiliensis occurs post-puberty predominantly in males led us to hypothesize that hormonal factors critically affect its pathogenesis. We show here that estrogens inhibit mycelial- to yeast-form transformation of P. brasiliensis in vitro. Transformation of three isolates was inhibited to 71, 33, and 19% of the control values in the presence of 10(-10), 10(-8), and 10(-6) M 17 beta-estradiol, respectively. The synthetic estrogen diethylstilbestrol was active but less potent than estradiol, whereas testosterone, 17 alpha-estradiol, tamoxifen, and corticosterone were inactive. This function was specifically inhibited, since yeast-to-mycelium transformation, yeast growth, and yeast reproduction by budding were unaffected by 17 beta-estradiol. Of note is the fact that mycelium-to-yeast transformation occurs as the first step in vivo in the establishment of infection. The cytosol of the three isolates studied possesses a steroid-binding protein which has high affinity for 17 beta-estradiol. We believe that this binding protein represents a P. brasiliensis hormone receptor which can also recognize mammalian estrogens. We hypothesize that the ability of estrogen to decrease or delay mycelium-to-yeast transformation at the initial site of infection contributes to or is responsible for the marked resistance of females, and that the binder described is the molecular site of action. Mención de responsabilidad : A Restrepo, M E Salazar, L E Cano, E P Stover, D Feldman, D A Stevens Referencia : Infect Immun. 1984 Nov;46(2):346-53. PMID : 6500694 En línea : https://iai.asm.org/content/46/2/346.long Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4327 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000828 AC-1984-001 Archivo digital Producción Científica Artículos científicos Disponible
