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Journal of Infectious Diseases
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Autre
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The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis / Mónica Rosa Trujillo Honeysberg
Título : The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 1997 Títulos uniformes : Journal of Infectious Diseases Idioma : Inglés (eng) Resumen : Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 mg significantly reduced tumor necrosis factor-α (TNF-α) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined. Mención de responsabilidad : María M. París, Sheila M. Hickey, Mónica Trujillo, Amina Ahmed, Kurt Olsen, George H. McCracken, Jr. Referencia : J Infect Dis. 1997 Nov;176(5):1239-46. DOI (Digital Object Identifier) : 10.1086/514118 PMID : 9359724 En línea : https://academic.oup.com/jid/article/176/5/1239/831438 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4380 The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 1997.
Obra : Journal of Infectious Diseases
Idioma : Inglés (eng)
Resumen : Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 mg significantly reduced tumor necrosis factor-α (TNF-α) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined. Mención de responsabilidad : María M. París, Sheila M. Hickey, Mónica Trujillo, Amina Ahmed, Kurt Olsen, George H. McCracken, Jr. Referencia : J Infect Dis. 1997 Nov;176(5):1239-46. DOI (Digital Object Identifier) : 10.1086/514118 PMID : 9359724 En línea : https://academic.oup.com/jid/article/176/5/1239/831438 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4380 Reserva
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