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Microbial Drug Resistance
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Autre
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Distribution of capsular types and antimicrobial susceptibility of invasive isolates of Streptococcus pneumoniae in Colombian children / Sergio Jaramillo Velásquez
Título : Distribution of capsular types and antimicrobial susceptibility of invasive isolates of Streptococcus pneumoniae in Colombian children Tipo de documento : documento electrónico Autores : Sergio Jaramillo Velásquez, Fecha de publicación : 1997 Títulos uniformes : Microbial Drug Resistance Idioma : Inglés (eng) Resumen : Streptococcus pneumoniae is the leading bacterial cause of childhood pneumonia in the developing world. This study describes the type distribution and antimicrobial susceptibility of invasive pneumococcal isolates from Colombian children and is part of the Sistema Regional de Vacunas (SIREVA), a PAHO regional initiative designed to determine the ideal serotype composition of a protein polysaccharide pneumococcal conjugate vaccine for use in children less than 5 years old in Latin America. In Colombia, during the study period, centres in Bogota, Medellin, and Cali collected 324 S. pneumoniae isolates from invasive diseases, 238 (73.5%) from children under the age of 2. Pneumonia was the clinical diagnosis in 41.3% cases, meningitis in 41%, and sepsis in 11.2%. The seven most frequent types included 14(21.9%), 5(10.5%), 23F(9.6%), 1(9%), 6B(9%), 19F(7.1%), and 6A(6.2%). The frequency of diminished susceptibility to penicillin (DSP) was 12%, with 8.9% of isolates showing intermediate level resistance and 3.1% showing high level resistance. Among DSP isolates, 23% were also resistant to cefotaxime, 33.3% to erythromycin, 48.7% to chloramphenicol, and 74.3% to trimethoprim/sulfamethoxazole. Multiple resistance was detected in 59% of the isolates that have DSP. Penicillin resistance was associated with types 23F (53.8%) and 14 (25.6%). These data provides information on capsular types prevalent in Colombia that will not only allow the formulation of an ideal vaccine for the region but also reinforce the need for ongoing regional surveillance. Mención de responsabilidad : E. CASTAÑEDA, A.L. LEAL, O. CASTILLO, F. De La HOZ, M.C. VELA, M. ARANGO, H. TRUJILLO, A. LEVY, M.E. GAMA, M. CALLE, M.L. VALENCIA, W. PARRA, N. AGUDELO, G.I. MEJÍA, S. JARAMILLO, F. MONTOYA, H. PORRAS, A. SÁNCHEZ, D. SAA, J.L. Di FABIO, A. HOMMA, and Pneumococcal Study Group in Colombia Referencia : Microb Drug Resist. Summer 1997;3(2):147-52. DOI (Digital Object Identifier) : 10.1089/mdr.1997.3.147 PMID : 9185142 En línea : https://www.liebertpub.com/doi/10.1089/mdr.1997.3.147 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4381 Distribution of capsular types and antimicrobial susceptibility of invasive isolates of Streptococcus pneumoniae in Colombian children [documento electrónico] / Sergio Jaramillo Velásquez, . - 1997.
Obra : Microbial Drug Resistance
Idioma : Inglés (eng)
Resumen : Streptococcus pneumoniae is the leading bacterial cause of childhood pneumonia in the developing world. This study describes the type distribution and antimicrobial susceptibility of invasive pneumococcal isolates from Colombian children and is part of the Sistema Regional de Vacunas (SIREVA), a PAHO regional initiative designed to determine the ideal serotype composition of a protein polysaccharide pneumococcal conjugate vaccine for use in children less than 5 years old in Latin America. In Colombia, during the study period, centres in Bogota, Medellin, and Cali collected 324 S. pneumoniae isolates from invasive diseases, 238 (73.5%) from children under the age of 2. Pneumonia was the clinical diagnosis in 41.3% cases, meningitis in 41%, and sepsis in 11.2%. The seven most frequent types included 14(21.9%), 5(10.5%), 23F(9.6%), 1(9%), 6B(9%), 19F(7.1%), and 6A(6.2%). The frequency of diminished susceptibility to penicillin (DSP) was 12%, with 8.9% of isolates showing intermediate level resistance and 3.1% showing high level resistance. Among DSP isolates, 23% were also resistant to cefotaxime, 33.3% to erythromycin, 48.7% to chloramphenicol, and 74.3% to trimethoprim/sulfamethoxazole. Multiple resistance was detected in 59% of the isolates that have DSP. Penicillin resistance was associated with types 23F (53.8%) and 14 (25.6%). These data provides information on capsular types prevalent in Colombia that will not only allow the formulation of an ideal vaccine for the region but also reinforce the need for ongoing regional surveillance. Mención de responsabilidad : E. CASTAÑEDA, A.L. LEAL, O. CASTILLO, F. De La HOZ, M.C. VELA, M. ARANGO, H. TRUJILLO, A. LEVY, M.E. GAMA, M. CALLE, M.L. VALENCIA, W. PARRA, N. AGUDELO, G.I. MEJÍA, S. JARAMILLO, F. MONTOYA, H. PORRAS, A. SÁNCHEZ, D. SAA, J.L. Di FABIO, A. HOMMA, and Pneumococcal Study Group in Colombia Referencia : Microb Drug Resist. Summer 1997;3(2):147-52. DOI (Digital Object Identifier) : 10.1089/mdr.1997.3.147 PMID : 9185142 En línea : https://www.liebertpub.com/doi/10.1089/mdr.1997.3.147 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4381 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000881 AC-1997-002 Archivo digital Producción Científica Artículos científicos Disponible