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Neoplasma
Tipo de obra :
Autre
Naturaleza de la obra :
Oeuvre
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Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes / Luis Vicente Syro Moreno
Título : Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes Tipo de documento : documento electrónico Autores : Luis Vicente Syro Moreno, Fecha de publicación : 2010 Títulos uniformes : Neoplasma Idioma : Inglés (eng) Palabras clave : immunohistochemistry endoglin CD34 microvascular density angiogenesis pituitary Resumen : Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. Mención de responsabilidad : F Rotondo, S Sharma, B W Scheithauer, E Horvath, L V Syro, M Cusimano, F Nassiri, G M Yousef, K Kovacs Referencia : Neoplasma. 2010;57(6):590-3. DOI (Digital Object Identifier) : 10.4149/neo_2010_06_590 PMID : 20845998 En línea : http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&produ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4470 Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes [documento electrónico] / Luis Vicente Syro Moreno, . - 2010.
Obra : Neoplasma
Idioma : Inglés (eng)
Palabras clave : immunohistochemistry endoglin CD34 microvascular density angiogenesis pituitary Resumen : Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. Mención de responsabilidad : F Rotondo, S Sharma, B W Scheithauer, E Horvath, L V Syro, M Cusimano, F Nassiri, G M Yousef, K Kovacs Referencia : Neoplasma. 2010;57(6):590-3. DOI (Digital Object Identifier) : 10.4149/neo_2010_06_590 PMID : 20845998 En línea : http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&produ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4470 Reserva
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